Protein Alignment GluRIB and gria3b

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_938174.1
• Gene: gria3b / 368416
• ZFINID: ZDB-GENE-030616-53
• Length: 883
• Species: Danio rerio
• Alignment Length: 983
• Identity: 404/983 - (41%)
• Similarity: 554/983 - (56%)
• Gaps: 163/983 - (16%)

  Fly    14 FLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYA--MLNHNLNVSSRRFE 76
            |||||..:|..|            ...:|.:|.:|.:.|.:..|||::|  :.|.|.|::.:.|.
Zfish     8 FLLWLFGTSLAG------------FPNQINIGGLFMRSTVQEHSAFRFAVQLYNTNQNMTEKPFH 60

  Fly    77 LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLT 141
            |...||.:.::::|.::...|:|||||||::.|.....|.:||.|:.......||||.:
Zfish    61 LNYNVDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDKKSMNTLTSFCGALHTSFVTPSY------ 119

  Fly   142 PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK 206
            |....:.|.:.|||....|::..:..|.|.|.:||||:..|...||.|.:.....|  :|| ..:
Zfish   120 PIDSDVQFVIQMRPPLKGAVLSLLSHYKWDKFVYLYDTDRGFSILQAIMEAAVANN--WQV-TAR 181

  Fly   207 RISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGL--- 266
            .:.:::...||...:|::.|.:.|..::||..:....||.|.|   .||:  |.|||:::.|
Zfish   182 SVGSITDPQEFRRIIEEMDRRQEKRYLIDCEVDRINVILEQVV---TLGKNSRGYHYIIANLGFT 243

  Fly   267 -VMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDA 330
             :..|:     :..|..||:||:|::....:|::|...|.|||.:....|....:...:||.|||
Zfish   244 NISLDK-----VFLGGANISGFQIINPENLVVQQFLQRWDRLDEREFPEAKNTPLKYTSALSYDA 303

  Fly   331 VFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGS 395
            :.|:.|||..:.|::.|     |.||
Zfish   304 ILVIAEAFRYLRRQRVD-----VSRR--------------------------------------- 324

  Fly   396 DSGGSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVV 458
               ||.|      ||  |.|.    .|..|..|.|.|:.|:::|:||:|:|:..|||.|||:.|.
Zfish   325 ---GSAG------DCLANPAV----PWSQGIDIERALKMVQVQGMTGNIQFDSFGRRTNYTIDVY 376

  Fly   459 EMTVNSAMVKVAEWND-DAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKL 522
            ||...... |:..||: :..:..::.::......||   |||.:|||::|.||:|.|:...  .|
Zfish   377 EMKTGGPR-KIGYWNEFERFVNIMDQQFTNDSSSVE---NRTIVVTTIMEAPYVMYKKNHM--HL 435

  Fly   523 HGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAM 587
            .||.::||||.|||..:||.:||.|.|.:|.||.||:...... .|:|||||||...||||:|.:
Zfish   436 EGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETK-SWNGMVGELVYGRADIAVAPL 499

  Fly   588 TITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVS 652
            |||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|||||:|||.||
Zfish   500 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 564

  Fly   653 RFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQA 717
            ||||:||:|    .:..:..||.                     .||.||
Zfish   565 RFSPYEWQL----DETDEVKDPQ---------------------TPPDPP--------------- 589

  Fly   718 ALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSY 782
                             |:|.::||.||||.||||||||:||||:||||....|:|||||:||||
Zfish   590 -----------------NDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSY 637

  Fly   783 TANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HV 846
            ||||||||||||||:||.|.||||.|||:.||||..|||.:|||||:|.::.|||.||.|.: .|
Zfish   638 TANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSV 702

  Fly   847 FVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPI 911
            |..|..:|:.|||.||||:|.|:||..|||:..|:||||||||.|||:||:|:|||.||||::.:
Zfish   703 FAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAV 767

  Fly   912 NLAVLTLKENGELIKLRNKWWYEKAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAI 975
            |||||.|.|.|.|.||:|||||:|.|| |...|.:...|.||||||||:||||:|||.:::.||:
Zfish   768 NLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVAL 832

  Fly   976 LEYCFRSR 983
            :|:|::||
Zfish   833 IEFCYKSR 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	128/445 (29%)
		ANF_receptor	55..461	CDD:279440	121/415 (29%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	240/441 (54%)
		Lig_chan	632..967	CDD:278489	179/336 (53%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	128/445 (29%)
		ANF_receptor	36..379	CDD:279440	121/416 (29%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	240/441 (54%)
		Lig_chan	544..824	CDD:278489	179/336 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590950
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770