Protein Alignment GluRIB and clumsy

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 1200
• Identity: 320/1200 - (26%)
• Similarity: 506/1200 - (42%)
• Gaps: 332/1200 - (27%)

  Fly    34 AQPSLTE----KIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSR 94
            |.|.|.:    :..:|:||....||.:.||:.|:  ...|:..|..||...|...||.|:|.:.:
  Fly    13 ALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAV--DRANILERNVELVPIVVYANTDDSFIMEK 75

  Fly    95 LICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMP-FVTPWFPEKVLTPSSGFLDFALSMRPD-- 156
            ::||..|:||.::.|..:..|.|.:.|..:|..:| .|..|.|.:.: |........|::.||
  Fly    76 MVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESI-PDREHSTMTLNVHPDNL 139

  Fly   157 -YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHT 220
             ..|.:.:.:|.:.||....:|::...|.:||.|.|...|            |||.:       |
  Fly   140 LLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEP------------ISNPT-------T 185

  Fly   221 LEQIGRFENKH-------------IVLDC-PTEMAKQILIQHVRDLR-LGRRTYHYLLSGLVMDD 270
            ::|:|..::..             ::|.| |..:.|  ::|...:|: ||.  |..:...|:
  Fly   186 VKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLK--ILQQANELKMLGE--YQSVFIPLL--- 243

  Fly   271 RWESEIIEFGAI-----NITGFRIVDTNRRLVREFYDSWK----------RLDPQMSVGAGRESI 320
              ::..|:||.:     |||..|::|.:...|:.....|:          ::||        ..:
  Fly   244 --DTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDP--------NRV 298

  Fly   321 SAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGN 385
            .:|..|:.|||::    |:|.|
  Fly   299 KSQMILLNDAVWL----FSKGL------------------------------------------- 316

  Fly   386 GGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRR 450
                     ::.|....:.:..|:|...|    .|..|.:|..:::....|..||.|.||::|:|
  Fly   317 ---------TELGIFEELTAPDLECRRKK----PWPFGKRIIEFIKARSEETSTGRIDFNENGQR 368

  Fly   451 VNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEK-------NRTYIVTTVLEE 508
            ..:||..:|:. :...:.:|.|:...||..||       ...|.||       |:|:||::.|..
  Fly   369 SFFTLRFMELN-SDGFLDLATWDPVNGLDVLN-------DDEESEKRVGQKLSNKTFIVSSRLGA 425

  Fly   509 PYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVG 573
            |::.|::...||.|.||:|:|||..||.:.:||.|...:|.|:..||.||: .:.....|||:|.
  Fly   426 PFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGA-LNKVTQTWDGIVR 489

  Fly   574 ELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVI 638
            :|:...||:.|..:|:|:.|.:.:||:.|||:|||||:..||......:|||::|.|.::|:.:.
  Fly   490 QLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMG 554

  Fly   639 FSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPT 703
            .:|:.:|::||.::|.:|.:|          ::|.|....|:
  Fly   555 SAYLFISLLLFALARMAPDDW----------ENPHPCKEPEE----------------------- 586

  Fly   704 PGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAA 768
                                         |.|.:|:.|:.|.|:.:.|.||||:.|::.|.|:..
  Fly   587 -----------------------------VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVT 622

  Fly   769 ASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLH 833
            ..|:||.|::::|||||||||||..|....|||.||||.|::::||.:..|||..|||.|....:
  Fly   623 GMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTY 687

  Fly   834 NKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGF 897
            .|||..|.|.. .||..|.|||::||:..|..||.|:||...|| |....||.:::|..||.|.:
  Fly   688 QKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEY-NVERKCDLVQIGGWLDYKSY 751

  Fly   898 GIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYE-----KAECSTHKDGETSHSELSLSNVA 957
            |||.|..|..:..|:.|||.|.|.|:|.:|:.|||.|     ..|.|....|:|  .||.|.||.
  Fly   752 GIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDT--PELGLENVG 814

  Fly   958 GIFYILIGGLLVSVFVAILEY-----------------CFRSR---------------------D 984
            |:|.:|..|||.::.:...|:                 .|:|.                     .
  Fly   815 GVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGS 879

  Fly   985 SRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTI 1049
            |.|:||.|..........|:|..|| |::|...:..|                   :|:|.|
  Fly   880 SNSSSSSSSRSKHSFKSQGLSMKSL-KSSGYQDVEAS-------------------VHSKLK--- 921

  Fly  1050 QASRDYDNGRVGYLNCASLQYYPPAQLSATPP-------------------DAGDSL-------- 1087
                     ::|  :..||:    :|.:.|||                   |....|
  Fly   922 ---------KIG--SMFSLK----SQKTVTPPPEIGWKLDKSTQIDVVPTSDVDQELIPEVEPHL 971

  Fly  1088 -----HMNAHGQVXHEHAQESRLXRTPCAP 1112
                 |.:.|....|.|..:....|.|..|
  Fly   972 PHRHHHHHHHRHHHHHHQPDQEHDRNPSPP 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	102/468 (22%)
		ANF_receptor	55..461	CDD:279440	95/439 (22%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	159/446 (36%)
		Lig_chan	632..967	CDD:278489	116/340 (34%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	103/469 (22%)
		ANF_receptor	39..379	CDD:279440	95/438 (22%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	157/436 (36%)
		Lig_chan	548..812	CDD:278489	111/328 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462510
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.790