DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria4b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	1079	Identity:	416/1079 - (38%)
Similarity:	570/1079 - (52%)	Gaps:	208/1079 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKLSCLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNL- 68
            |..||:|                 |:.:.|.||   .:.:|.:|.:.||:..:||:.|:..||.
Zfish    10 LLFSCVW-----------------GLTMGAFPS---SVQIGGLFIRNTDQEYTAFRLAIFLHNTS 54

  Fly    69 -NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVT 132
             |.|...|.|..:||.|.||::|.::...|:|:||||:::.|.....|..||.|:.....:..:|
Zfish    55 PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCGALHISLIT 119

  Fly   133 PWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGN 197
            |.|      |:.|...|.|.:||....|::..:..|.|.:.::|||:..|...||.|.:  :.|.
Zfish   120 PSF------PTEGESQFVLQLRPSIRGALLSLLDHYDWNRFVFLYDTDRGYSILQAIME--KAGQ 176

  Fly   198 ESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYH 260
            ..:||..: .:.|.:.| .:...||.:.|.:.|..|:|...|....:|.|.|   .:|:  :.||
Zfish   177 NGWQVSAI-CVENFNDA-SYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIV---SVGKHVKGYH 236

  Fly   261 YLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAA 325
            |:::.|...| ...|....|..|:|||::||.:..:|.:....|.:||.:...|:.... ...:|
Zfish   237 YIMANLGFKD-INLERFMHGGANVTGFQLVDFSNPMVIKLMQRWNKLDQREYPGSDAPP-KYTSA 299

  Fly   326 LMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGG 390
            |.||.|.|:.|||..:.|:|.|     :.||
Zfish   300 LTYDGVMVMAEAFRNLRRQKVD-----ISRR---------------------------------- 325

  Fly   391 GFAGSDSGGSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNY 453
            |.||              ||  |.|.    .|..|..:.|.|::|.::||||:::|:..||||||
Zfish   326 GIAG--------------DCLANPAA----PWNQGIDMERTLKQVHLQGLTGNVQFDHYGRRVNY 372

  Fly   454 TLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAF 518
            |:.|.|:..|... ::..|| ||....|...:..|.......:|||.||||::|.||:|||:  .
Zfish   373 TMDVFELKSNGPR-RIGYWN-DADKLVLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLKK--N 433

  Fly   519 GEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIA 583
            .|...||.::||||.|||..:||.:|..|::.:|.||.||:...... .|:|||||||..:|:||
Zfish   434 WEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPETK-IWNGMVGELVYGKAEIA 497

  Fly   584 IAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVL 648
            :|.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|||||:||
Zfish   498 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 562

  Fly   649 FFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAA 713
            |.||||||:||          .:.:|....:.|.:.|||
Zfish   563 FLVSRFSPYEW----------HTEEPEEGTDGLPSDQPP-------------------------- 591

  Fly   714 ALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLIL 778
                                 |||.::||.||||.||||||||:||||:||||....|:|||||:
Zfish   592 ---------------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 635

  Fly   779 ISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSR 843
            ||||||||||||||||||:||.|.||||.||::.||||..|||.:|||||:|.::.|||.||.|.
Zfish   636 ISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 700

  Fly   844 K-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSAL 907
            : .||..|..||:.|||.||||||.|:||..|||...|:||||||||.|||:||:|:|||.||.|
Zfish   701 EPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQL 765

  Fly   908 KDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSE--LSLSNVAGIFYILIGGLLVS 970
            :..:|||||.|.|.|.|.||:|||||:|.||.:...||...|.  ||||||||:||||:|||.::
Zfish   766 RSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQALSLSNVAGVFYILVGGLGLA 830

  Fly   971 VFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRS 1035
            :.||::|:|::||:.                                            :...:.
Zfish   831 MLVALIEFCYKSRNE--------------------------------------------AKRMKL 851

  Fly  1036 TLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPA 1074
            |.|:.|..||:|:|..|.. :||||...:|....:..|:
Zfish   852 TFTEAMRNKARLSITGSVG-ENGRVLTPDCPKAVHSGPS 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	128/440 (29%)
		ANF_receptor	55..461	CDD:279440	119/411 (29%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	238/441 (54%)
		Lig_chan	632..967	CDD:278489	178/337 (53%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	128/443 (29%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	237/438 (54%)
		Lig_chan	546..827	CDD:306551	178/337 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590922
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770