Protein Alignment GluRIB and Nmdar2

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 1096
• Identity: 214/1096 - (19%)
• Similarity: 395/1096 - (36%)
• Gaps: 324/1096 - (29%)

  Fly    22 SGGGGGSGVGVSAQPSLTEKIPLGAIFEQ-----------------GTDEVQSAFKYAMLNHNLN 69
            :.|||....|.:|.   .|::.:|.|...                 |..:.:.|....:.:::..
  Fly    84 TNGGGSLSKGAAAN---KEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFE 145

  Fly    70 VSSRRFELQAYVDVINTADAFKLSRLICNQFSR-GVYSMLGAVSPDSFDTLHSYSNT-------- 125
            ..:..|::.:.     |.....:...:|.:|.| .|.::|..::.:.|.  ||.::.
  Fly   146 QKNIHFDMMSL-----TPSPTAILSTLCKEFLRVNVSAILYMMNNEQFG--HSTASAQYFLQLAG 203

  Fly   126 -FQMPFVTPWFP-----EKVLTPSSGFLDFALSMRPDYHQ--AIIDTIQFYGWRKIIYLYD---S 179
             ..:|.:: |..     |:..:.|:..|..|.|:.   ||  |::..::.|.|.:...:..   .
  Fly   204 YLGIPVIS-WNADNSGLERRASQSTLQLQLAPSIE---HQSAAMLSILERYKWHQFSVVTSQIAG 264

  Fly   180 HDGLLRLQQIYQGLRPGNESFQVELVKRI--SNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAK 242
            ||..  :|.:.:.:....|.|:..::..|  :..|..:|.:::        ...::|...|:...
  Fly   265 HDDF--VQAVRERVAEMQEHFKFTILNSIVVTRTSDLMELVNS--------EARVMLLYATQTEA 319

  Fly   243 QILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRL 307
            ..:::...:::|....|.:::|..|::.                                  |..
  Fly   320 ITILRAAEEMKLTGENYVWVVSQSVIEK----------------------------------KDA 350

  Fly   308 DPQMSVG-AGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSS 371
            ..|..|| .|....::.||||           |:|               |..:.:
  Fly   351 HSQFPVGMLGVHFDTSSAALM-----------NEI---------------SNAIKI--------- 380

  Fly   372 DGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC-NTAKGWVNAWEHGDKISRYLRKVEI 435
              |:|...           .:....:.....:.:::|.| :..:|   .|::|:...:|||.|.|
  Fly   381 --YSYGVE-----------AYLTDPANRDRRLTTQSLSCEDEGRG---RWDNGEIFFKYLRNVSI 429

  Fly   436 EGLTG--DIKFNDDGRRVNYTLHVVEM-----TVNSAMVKVAEW-----------------NDDA 476
            ||...  :|:|..||...:..|.::.:     ..|....::..|                 |..|
  Fly   430 EGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHA 494

  Fly   477 GLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYI-----------------MLKQVAFGEKL-- 522
            ..|.:..|:     |::        :|.:.|.|||                 :|.:||...::
  Fly   495 PPQGVPEKF-----HLK--------ITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAA 546

  Fly   523 -------HGNNRF----EGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
                   |.|..|    .|:|.||.:..|:|||..|||..|:||.:|:.:   :|.|:|::.:||
  Fly   547 DIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTLE---NGKWNGLIADLV 608

  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFS---FMNPLSQEIWVSVI 638
            .::.|:.:.::.|..|||.|:|||:|||..||:|::.|    ..|:.|   |:.|.....|:.|
  Fly   609 NRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAK----RTGIISPTAFLEPFDTASWMLV- 668

  Fly   639 FSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPT 703
             ..:.:....|.:..|   ||.            .|..:..:|..|
  Fly   669 -GIVAIQAATFMIFLF---EWL------------SPSGYDMKLYLQ------------------- 698

  Fly   704 PGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIA 767
                                     :::.....||::.::|...|...|....: |||..:.|..
  Fly   699 -------------------------NTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFM 738

  Fly   768 AASWFFFTLILISSYTANLAAF------------LTVERMVTPINSPEDLAMQTEVQYGTLLHGS 820
            ...|..|.::.::.||||||||            |...|:|.|.:.      :...::||:.:..
  Fly   739 TNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSH------KPSFKFGTIPYSH 797

  Fly   821 TWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCD 884
            |.....:....:||.|.:|..:       :..:|:..|.|. ...:.:.:....:|:.|: |.|.
  Fly   798 TDSTIHKYFNVMHNYMRQYNKT-------SVADGVAAVLNG-NLDSFIYDGTVLDYLVAQDEDCR 854

  Fly   885 TMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHS 949
            .|.||......|:|:|....|......|..:|..:.||:|.:||..|.  ...|...|....|..
  Fly   855 LMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWM--TGTCRPGKQEHKSSD 917

  Fly   950 ELSLSNVAGIFYILIGGLLVSVFVAILEYC-FRSRDSRSASSGSG-----MGLGMG 999
            .|:|......|.:|:.|:|::..:.:||:. |:....|.|....|     :.|.||
  Fly   918 PLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISLSMG 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	75/499 (15%)
		ANF_receptor	55..461	CDD:279440	68/436 (16%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	112/487 (23%)
		Lig_chan	632..967	CDD:278489	68/348 (20%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	74/496 (15%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	115/502 (23%)
		Lig_chan	665..928	CDD:278489	66/339 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I1556
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890