DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grik3

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	1010	Identity:	326/1010 - (32%)
Similarity:	501/1010 - (49%)	Gaps:	195/1010 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFE-------QGTDEVQSAFKYA--MLNH 66
            |..||:...|.....|           :...|.:|.|||       |..:..:.||:::  ::|.
  Rat    16 WAGFLVCAFWIPDSRG-----------MPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINR 69

  Fly    67 N---LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQM 128
            |   |..::..:::|.    |:..|:|:.::..|:|.:.||.::.|.......:.:.|..|..::
  Rat    70 NRTLLPNTTLTYDIQR----IHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEV 130

  Fly   129 PFVTPWFPEKVLTPSSGFLDFALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIY 190
            |.:...:....|....   .|.:::.|||   ..||:|.:|...||....:||...||:|||::.
  Rat   131 PHIQLRWKHHPLDNKD---TFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELI 192

  Fly   191 QGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLG 255
            ......|...::..:...|:.|..:     |:::.|.....|:.||...||.|||.|   .:.:|
  Rat   193 MAPSRYNIRLKIRQLPIDSDDSRPL-----LKEMKRGREFRIIFDCSHTMAAQILKQ---AMAMG 249

  Fly   256 RRT--YHYLLSGLVMDDRW--ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD--PQMS 312
            ..|  ||::.:.|   |.:  :.|...:..:|:|||||::.:...|....:.|  :||.  |:..
  Rat   250 MMTEYYHFIFTTL---DLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAE 311

  Fly   313 VGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYS 377
            .|.....:...|||:||||.::...:               ||..|
  Rat   312 SGLLDGVMMTDAALLYDAVHIVSVCY---------------QRAPQ------------------- 342

  Fly   378 ASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDI 442
                                     |...:|.|:..|    ||..|.:...::::.:.|||||.|
  Rat   343 -------------------------MTVNSLQCHRHK----AWRFGGRFMNFIKEAQWEGLTGRI 378

  Fly   443 KFN-DDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHV-EFEKNRTYIVTTV 505
            .|| ..|.|.::.|.::.:. ...:.||..|:...||........| .|:| :...||:.||||:
  Rat   379 VFNKTSGLRTDFDLDIISLK-EDGLEKVGVWSPADGLNITEVAKGR-GPNVTDSLTNRSLIVTTL 441

  Fly   506 LEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDG 570
            ||||::|.::  ....|:||:||||||.||...||..||.:||:|||:||.||::...  |.|:|
  Rat   442 LEEPFVMFRK--SDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDK--GQWNG 502

  Fly   571 MVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWV 635
            ||.||:..:||:|:|.:|||..||:.||||||||:||:||:.:||....|.||||:||||.:||:
  Rat   503 MVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWM 567

  Fly   636 SVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPG 700
            .|:.:|:|||.|||.::||||:||.            |.|                    |..||
  Rat   568 YVLLAYLGVSCVLFVIARFSPYEWY------------DAH--------------------PCNPG 600

  Fly   701 PPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGR 765
                                         |..|.|.|::.|||||.:.:.||||.:|.|:::|.|
  Rat   601 -----------------------------SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTR 636

  Fly   766 IAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQI 830
            |....|:|||||:|||||||||||||||||.:||:|.:|||.||:::||.:..|:|..||::|:|
  Rat   637 IIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKI 701

  Fly   831 GLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTK 895
            ....|||.:|:|:....|...:|||:|...:  .||||:||...||:..|. |:..::|..:|:|
  Rat   702 STFEKMWAFMSSKPSALVKNNEEGIQRTLTA--DYALLMESTTIEYITQRN-CNLTQIGGLIDSK 763

  Fly   896 GFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIF 960
            |:||.||:||..:|.|.:|:|.|:|..:|..::.||| ..:.|...::.|.  |.|.:..:.|||
  Rat   764 GYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCPEEENKEA--SALGIQKIGGIF 825

  Fly   961 YILIGGLLVSVFVAILEYCFR-----SRDSRSASS 990
            .:|..||::||.||:.|:.::     .|:.||..|
  Rat   826 IVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCS 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	104/458 (23%)
		ANF_receptor	55..461	CDD:279440	96/422 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	192/440 (44%)
		Lig_chan	632..967	CDD:278489	126/334 (38%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	107/464 (23%)
		ANF_receptor	55..398	CDD:279440	96/423 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	192/436 (44%)
		Lig_chan	564..832	CDD:278489	126/334 (38%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650