DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Gria4

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	1048	Identity:	416/1048 - (39%)
Similarity:	570/1048 - (54%)	Gaps:	197/1048 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNL--NVSSRRFELQAYVDVINTADAFK 91
            |:.:.|.||   .:.:|.:|.:.||:..:||:.|:..||.  |.|...|.|..:||.|.||::|.
  Rat    17 GLAMGAFPS---SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFA 78

  Fly    92 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPD 156
            ::...|:|:||||:::.|.....|..||.|:.:...:..:||.|      |:.|...|.|.:||.
  Rat    79 VTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSF------PTEGESQFVLQLRPS 137

  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVE--LVKRISNVSMAIEFLH 219
            ...|::..:..|.|...::|||:..|...||.|.:  :.|...:.|.  .|:..::||    :..
  Rat   138 LRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIME--KAGQNGWHVSAICVENFNDVS----YRQ 196

  Fly   220 TLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDDRWESEIIEFGAI 282
            .||::.|.:.|..|:||..|..:.||.|.|   .:|:  :.|||:::.|...|......|..||
  Rat   197 LLEELDRRQEKKFVIDCEIERLQNILEQIV---SVGKHVKGYHYIIANLGFKDISLERFIHGGA- 257

  Fly   283 NITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPD 347
            |:|||::||.|..:|.:..|.||:|| |.............:||.||.|.|:.|.|..:.|:|.|
  Rat   258 NVTGFQLVDFNTPMVTKLMDRWKKLD-QREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKID 321

  Fly   348 QFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC-- 410
                 :.||                           ||.|                     ||
  Rat   322 -----ISRR---------------------------GNAG---------------------DCLA 333

  Fly   411 NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDD 475
            |.|.    .|..|..:.|.|::|.|:||||:::|:..|||||||:.|.|:. ::...||..|||.
  Rat   334 NPAA----PWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELK-STGPRKVGYWNDM 393

  Fly   476 AGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLA 540
            ..| .|......|.......:|||.:|||::|.||:|.|:  ..|...||:::||||.|||..:|
  Rat   394 DKL-VLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKK--NHEMFEGNDKYEGYCVDLASEIA 455

  Fly   541 KELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMS 605
            |.:||.|::.:|.||.||:..:... .|:|||||||..:|:||||.:|||..||.||||||||||
  Rat   456 KHIGIKYKIAIVPDGKYGARDADTK-IWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMS 519

  Fly   606 LGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQ-S 669
            ||||||||||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||.  .::|:. .
  Rat   520 LGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH--TEEPEDGK 582

  Fly   670 QSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVV 734
            :.|          :.|||
  Rat   583 EGP----------SDQPP----------------------------------------------- 590

  Fly   735 NEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPI 799
            |||.::||.||||.||||||||:||||:||||....|:|||||:||||||||||||||||||:||
  Rat   591 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 655

  Fly   800 NSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKG 863
            .|.||||.|||:.||||..|||.:|||||:|.::.|||.||.|.: .||..|..||:.|||.|||
  Rat   656 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKG 720

  Fly   864 KYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLR 928
            |:|.|:||..|||:..|:||||||||.|||:||:|:|||.||:|::.:|||||.|.|.|.|.||:
  Rat   721 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDKLK 785

  Fly   929 NKWWYEKAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGS 992
            |||||:|.|| |...|.:...|.||||||||:||||:|||.:::.||::|:|::||
  Rat   786 NKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR--------- 841

  Fly   993 GMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDYDN 1057
                                               ..:...:.|.::.:..||:|:|..|.. :|
  Rat   842 -----------------------------------AEAKRMKLTFSEAIRNKARLSITGSVG-EN 870

  Fly  1058 GRVGYLNC 1065
            |||...:|
  Rat   871 GRVLTPDC 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	134/442 (30%)
		ANF_receptor	55..461	CDD:279440	125/413 (30%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	238/442 (54%)
		Lig_chan	632..967	CDD:278489	178/337 (53%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	135/445 (30%)
		ANF_receptor	39..380	CDD:279440	125/414 (30%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	238/442 (54%)
		Lig_chan	546..825	CDD:278489	178/337 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349644
Domainoid	1	1.000	343	1.000	Domainoid score	I1030
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I623
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9111
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.770