DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and Gria2

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_001077280.1 Gene:Gria2 / 29627 RGDID:61862 Length:883 Species:Rattus norvegicus


Alignment Length:995 Identity:409/995 - (41%)
Similarity:559/995 - (56%) Gaps:194/995 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQA 79
            :||         |...|||     :..|.:|.:|.:|.|:..|||:..|    :..|:..|.|..
  Rat    14 VLW---------GLIFGVS-----SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTP 60

  Fly    80 YVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSS 144
            ::|.:..|::|.::...|:|||||||::.|.....|.:|:.|:..|..:.|:||.|      |:.
  Rat    61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTD 119

  Fly   145 GFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK--R 207
            |...|.:.||||...|::..|::|.|.|..|||||..||..||.:...  ...:.:||..:.  .
  Rat   120 GTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS--AAEKKWQVTAINVGN 182

  Fly   208 ISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDD 270
            |:|......:....:.:...:.:.::|||..:....|:.|.:   .:|:  :.|||:::.|...|
  Rat   183 INNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI---TIGKHVKGYHYIIANLGFTD 244

  Fly   271 RWESEI--IEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFV 333
               .::  |:||..|::||:|||.:..||.:|.:.|..|:.:...||...:|...:||.||||.|
  Rat   245 ---GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQV 306

  Fly   334 LVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSG 398
            :.|||.. |||:    |..:.||                           ||.|           
  Rat   307 MTEAFRN-LRKQ----RIEISRR---------------------------GNAG----------- 328

  Fly   399 GSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT 461
                      ||  |.|.    .|..|.:|.|.|::|::|||:|:|||:.:|:|:|||::::|:.
  Rat   329 ----------DCLANPAV----PWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379

  Fly   462 VNSAMVKVAEW----------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPY 510
            .|... |:..|                ||.:||:                 |:|.:|||:||.||
  Rat   380 TNGPR-KIGYWSEVDKMVVTLTELPSGNDTSGLE-----------------NKTVVVTTILESPY 426

  Fly   511 IMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGEL 575
            :|:|:  ..|.|.||.|:||||.|||..:||..|..|:|.:|.||.||:..:... .|:||||||
  Rat   427 VMMKK--NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGEL 488

  Fly   576 VRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640
            |..:||||||.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:
  Rat   489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553

  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPG 705
            |||||:|||.||||||:||                 |.|:..:                     |
  Rat   554 YIGVSVVLFLVSRFSPYEW-----------------HTEEFED---------------------G 580

  Fly   706 AQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAAS 770
            .:|                    .||...|||.::||.||||.|||:||||:||||:||||....
  Rat   581 RET--------------------QSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGV 625

  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNK 835
            |:|||||:||||||||||||||||||:||.|.|||:.|||:.||||..|||.:|||||:|.:.:|
  Rat   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK 690

  Fly   836 MWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGI 899
            ||.||.|.: .|||.|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:||
  Rat   691 MWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755

  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAEC-STHKDGETSHSELSLSNVAGIFYIL 963
            |||.||:|.:.:|||||.|.|.|.|.||:|||||:|.|| |...|.:...|.||||||||:||||
  Rat   756 ATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYIL 820

  Fly   964 IGGLLVSVFVAILEYCFRSR 983
            :|||.:::.||::|:|::||
  Rat   821 VGGLGLAMLVALIEFCYKSR 840

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 131/458 (29%)
ANF_receptor 55..461 CDD:279440 122/413 (30%)
PBP2_iGluR_AMPA 497..938 CDD:270433 243/441 (55%)
Lig_chan 632..967 CDD:278489 180/336 (54%)
Gria2NP_001077280.1 PBP1_iGluR_AMPA_GluR2 28..397 CDD:107384 129/444 (29%)
ANF_receptor 56..379 CDD:279440 117/393 (30%)
PBP2_iGluR_AMPA 413..794 CDD:270433 243/441 (55%)
Glutamate binding 499..501 0/1 (0%)
Lig_chan 545..824 CDD:278489 180/336 (54%)