DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and GRIN2D

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:1338 Identity:289/1338 - (21%)
Similarity:448/1338 - (33%) Gaps:468/1338 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 GGGGGSGVGV-SAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINT 86
            ||.||.|.|: .|:|.....:..|..:......:..|...|:.:..|:|  |...|     |:|.
Human    36 GGAGGPGGGLGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDV--RPVAL-----VLNG 93

  Fly    87 ADAFKLSRLICNQFS----RGVY----SMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTP 142
            :|...|...:|:..|    .||.    |...||:|    .|...|....:|.| .......||||
Human    94 SDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAP----ILDFLSAQTSLPIVAVHGGAALVLTP 154

  Fly   143 ---SSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVEL 204
               .|.||....|..... |.|.:.::.|.|...:.:...              .||:.:| :..
Human   155 KEKGSTFLQLGSSTEQQL-QVIFEVLEEYDWTSFVAVTTR--------------APGHRAF-LSY 203

  Fly   205 VKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMD 269
            ::.:::.|:          :|                                            
Human   204 IEVLTDGSL----------VG-------------------------------------------- 214

  Fly   270 DRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVL 334
              ||..    ||:.                       |||    |||...:|||           
Human   215 --WEHR----GALT-----------------------LDP----GAGEAVLSAQ----------- 235

  Fly   335 VEAFNKILRKKPDQFRNNVQRRSQTLMVAQAA--ASTSSDGYNYSASG----GGGGNGGAG---- 389
                   ||....|.|.....|.:...|.:||  |..:..||.:...|    ||||:|..|    
Human   236 -------LRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGSGYVWFMVGPQLAGGGGSGAPGEPPL 293

  Fly   390 --GG-------FAGSDSGGSGGMASRAL-------------------------DCNTAKGWVNAW 420
              ||       ||...:|....:|.|..                         ||...    |..
Human   294 LPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQ----NRT 354

  Fly   421 EHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQ---PLN 482
            ..|:.:.||...:..:  ..|..||:||..||.:|.|:.:|.:.....|..|.... |:   ||.
Human   355 HRGESLHRYFMNITWD--NRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQT-LRLKYPLW 416

  Fly   483 AKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGN------------NR-------- 527
            ::|.|....|:..::.|  |.|:.|.|:::::.   .:.:.|.            ||        
Human   417 SRYGRFLQPVDDTQHLT--VATLEERPFVIVEP---ADPISGTCIRDSVPCRSQLNRTHSPPPDA 476

  Fly   528 -------FEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIA 585
                   .:|:|.|:...||..:|.:|:|.||.:|.:|.:   ..|.|:||:||:..:.||:||.
Human   477 PRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKK---IDGVWNGMIGEVFYQRADMAIG 538

  Fly   586 AMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFF 650
            ::||..||..::|||.||:..|||:|:.:. ..|....:|:.|.|..:||.:....:.|..|..|
Human   539 SLTINEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVF 602

  Fly   651 VSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAAL 715
            :..:.                 .|..::..||..:.|                            
Human   603 IFEYL-----------------SPVGYNRSLATGKRP---------------------------- 622

  Fly   716 QAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILI 779
                       |||:      |::..|.|...|........: :||..:.:|....|.||.:|.:
Human   623 -----------GGST------FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFL 670

  Fly   780 SSYTANLAAFLTVERMVTPINSPEDLAMQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMWE 838
            :|||||||||:..|..|..::...|...|      ..:::||:.:|||....|.:...:|:.|..
Human   671 ASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVR 735

  Fly   839 YMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCD--TMKVGRNLDTKGFGIAT 901
            |..       |..:|.:.:::..|....:...:..|......|.|.  |:..|:...|.|:|||.
Human   736 YNQ-------PRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIAL 793

  Fly   902 PLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYILIG 965
            ..||..|.||:||:|....:.|:..|...|.  ...|  |.|. |...|:|.:.|:||:||:|:.
Human   794 HKGSRWKRPIDLALLQFLGDDEIEMLERLWL--SGIC--HNDKIEVMSSKLDIDNMAGVFYMLLV 854

  Fly   966 GLLVSVFVAI--------LEYCF------------------------------------------ 980
            .:.:|:.|..        |.:|.                                          
Human   855 AMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPA 919

  Fly   981 ----------------------RSRDSRSAS--SGSGM--------------GLGMGLGGGMSG- 1006
                                  |.|.::.|.  .|:|:              |||:|||...:. 
Human   920 YPAPRPAPGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYYGPIEPQGLGLGLGEARAAP 984

  Fly  1007 -GSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQY 1070
             |:.|:.     |.|.:|.|...|.....:.:.|...|:                          
Human   985 RGAAGRP-----LSPPAAQPPQKPPPSYFAIVRDKEPAE-------------------------- 1018

  Fly  1071 YPPAQLSATP----PDAGDSLHMNAHGQVXHEHAQESRLXRTPCAPTIRRIMANSRQETEKMMG- 1130
             |||  .|.|    |.|..:....|.|......|.|.   .:|.||.   ....|..|::.::| 
Human  1019 -PPA--GAFPGFPSPPAPPAAAATAVGPPLCRLAFED---ESPPAPA---RWPRSDPESQPLLGP 1074

  Fly  1131 --GGHGGTVTVSVPATCSSSMNGSHEGSLALSPSSGSA 1166
              ||.|||             .|:..|:.|..|...:|
Human  1075 GAGGAGGT-------------GGAGGGAPAAPPPCRAA 1099

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 96/490 (20%)
ANF_receptor 55..461 CDD:279440 92/461 (20%)
PBP2_iGluR_AMPA 497..938 CDD:270433 116/476 (24%)
Lig_chan 632..967 CDD:278489 81/344 (24%)
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601 98/502 (20%)
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 117/481 (24%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:Q00959 539..541 0/1 (0%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 3/18 (17%)