Protein Alignment GluRIB and GRIN2C

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_016880033.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1337
• Species: Homo sapiens
• Alignment Length: 1298
• Identity: 282/1298 - (21%)
• Similarity: 451/1298 - (34%)
• Gaps: 377/1298 - (29%)

  Fly    10 LWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRR 74
            |.|:.||...:.:..|.|.|.|   :..:|.     |:....:...|:.|:            .|
Human    80 LGPALLLTSLFGAWAGLGPGQG---EQGMTV-----AVVFSSSGPPQAQFR------------AR 124

  Fly    75 FELQAYVDV----------INTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYS 123
            ...|:::|:          :||.:...|...||...  |...:.|.|..|:.||      |...|
Human   125 LTPQSFLDLPLEIQPLTVGVNTTNPSSLLTQICGLL--GAAHVHGIVFEDNVDTEAVAQILDFIS 187

  Fly   124 NTFQMPFVT-PWFPEKVLT---PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLL 184
            :...:|.:: ......|||   |.|.||...:|:.... |.:...::.|.|...
Human   188 SQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAF----------- 240

  Fly   185 RLQQIYQGLRPGNESF--QVELVKRISNVSMAIEFLHTLEQIG----RFENKHIV--LDCPTEMA 241
               .:...|.||:..|  .|..|...|:||..:..:.||| :|    |...:.::  ||.|..:|
Human   241 ---AVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLE-LGPGGPRARTQRLLRQLDAPVFVA 301

  Fly   242 KQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEII--EFGAINITGFRIVDTNRRLVREFYDSW 304
                               |.       .|.|:|::  |.....:.|...|             |
Human   302 -------------------YC-------SREEAEVLFAEAAQAGLVGPGHV-------------W 327

  Fly   305 KRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAAST 369
              |.|.:::|:   :.:..|......:.|:.|::...||:|                |....|..
Human   328 --LVPNLALGS---TDAPPATFPVGLISVVTESWRLSLRQK----------------VRDGVAIL 371

  Fly   370 SSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVE 434
            :...::|...                    .|.:.:.|.||....|.|:...  :...|:|..|.
Human   372 ALGAHSYWRQ--------------------HGTLPAPAGDCRVHPGPVSPAR--EAFYRHLLNVT 414

  Fly   435 IEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKY-------VRLRPHV 492
            .||  .|..|:..|..|..|:.|:.:..:.....|..|....    |..||       ..|:|.|
Human   415 WEG--RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWEHGV----LYMKYPVWPRYSASLQPVV 473

  Fly   493 EFEKNRTYIVTTVLEEPYIMLKQVAFGE----------KLHGNNRF-------------EGYCKD 534
            :   :|...|.|:.|.|:::::....|.          :...|:.|             :|:|.|
Human   474 D---SRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCID 535

  Fly   535 LADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDF 599
            :...||:.:..:|:|.||.:|.:|..   ..|.|:||:||:..|.||:||.::||..||..::||
Human   536 ILKKLARVVKFSYDLYLVTNGKHGKR---VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDF 597

  Fly   600 SKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSV-IFSYIGVSIVLFFVSRFSPHEWRLVQ 663
            |.||:..|||:|:.:. ..|....:|:.|.|..:||.: :.....|:|.:|....|||..:
Human   598 SVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY---- 657

  Fly   664 QQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGG 728
                               ||.                                 |:.|.. |||
Human   658 -------------------NQN---------------------------------LTRGKK-SGG 669

  Fly   729 SSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISSYTANLAAFLTV 792
            .:      |::..|.|...|........: :||..:.:|....|.||.:|.::|||||||||:..
Human   670 PA------FTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 728

  Fly   793 ERMVTPINSPED-------------LAMQT--------------EVQYGTLLHGSTWDFFRRSQI 830
            |:.:..::...|             .|.:|              ..::||:.:|||....|.:..
Human   729 EQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYR 793

  Fly   831 GLHNKMWEYMNSRK---------------------HVFVPTYDEGIKRVRNSKGKYALLVESPKN 874
            .:|..|.:: |.|.                     ..|:  ||..:......|.:...||
Human   794 DMHTHMVKF-NQRSVEDALTSLKMGSEAQPVPRKLDAFI--YDAAVLNYMAGKDEGCKLV----- 850

  Fly   875 EYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECS 939
                      |:..|:...|.|:|||....|..|..|:||:|....:||..||...|.  ...|.
Human   851 ----------TIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL--SGICQ 903

  Fly   940 THKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGM 1004
            ..|: |...|:|.:.|:||:||:|:..:.:::.|...|:....:...|..:.|.:...:....|:
Human   904 NEKN-EVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGI 967

  Fly  1005 SGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTI--------QASRDYDN---- 1057
            .....|..  |:...|..|.|....||.|.|.|.....|:..:|.        :|:|..:|
Human   968 YSCFSGVQ--SLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVSSSLDRATRTIENWGGG 1030

  Fly  1058 -----------GRVGYLNCASLQYYPPAQLSAT---PPDAGDSLHMNAHGQVXHEHAQESRLXRT 1108
                       .|.|...|.... .||.:.|.|   |||.|       ...:.....|......|
Human  1031 RRAPPPSPCPTPRSGPSPCLPTP-DPPPEPSPTGWGPPDGG-------RAALVRRAPQPPGRPPT 1087

  Fly  1109 PCAP--TIRRIMANSRQETEKMMGGGH-GGTVTVS----VPATCSSSMNGSHEGSLALSPSSG 1164
            |..|  .:.|:......|....:..|| |..::.|    .||.|       |..|...:..||
Human  1088 PGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARC-------HYSSFPRADRSG 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	88/464 (19%)
		ANF_receptor	55..461	CDD:279440	85/435 (20%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	120/513 (23%)
		Lig_chan	632..967	CDD:278489	84/384 (22%)
GRIN2C	XP_016880033.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740