back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	1168	Identity:	249/1168 - (21%)
Similarity:	433/1168 - (37%)	Gaps:	336/1168 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KLSCLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIP--LG-AIFEQGT-DEVQSAFKYAMLN- 65
            :..|..|.|  ||..:.       :.||...:.::|.|  :| |:...|| |||  |.|.|...
Human     4 RAECCSPKF--WLVLAV-------LAVSGSRARSQKSPPSIGIAVILVGTSDEV--AIKDAHEKD 57

  Fly    66 --HNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQM 128
              |:|:|.. |.||.|    :|..|...:...||:..|.  ..:.|.|..|..|       ...:
Human    58 DFHHLSVVP-RVELVA----MNETDPKSIITRICDLMSD--RKIQGVVFADDTD-------QEAI 108

  Fly   129 PFVTPWFPEKVLTP-----------------SSGFLDFALSMRPDYHQA--IIDTIQFYGWRKII 174
            ..:..:...:.|||                 ||.|..|..|:.   .||  :::.::.|.|
Human   109 AQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE---QQASVMLNIMEEYDW---- 166

  Fly   175 YLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL--------------EQIG 225
            |::          .|.....||.:.|..::...|.|..:..|....|              .|:.
Human   167 YIF----------SIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLK 221

  Fly   226 RFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEF--GAINITGFR 288
            :.::..|:|.|..|.|..| .:....:.|....|.:::..||..|. ::...||  |.|:::
Human   222 KLQSPIILLYCTKEEATYI-FEVANSVGLTGYGYTWIVPSLVAGDT-DTVPAEFPTGLISVS--- 281

  Fly   289 IVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNV 353
                        ||.|....|               |.:.|.:.::..|.:.:|
Human   282 ------------YDEWDYGLP---------------ARVRDGIAIITTAASDML----------- 308

  Fly   354 QRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVN 418
               |:...:.:..:|.    ||..                          ..|....|
Human   309 ---SEHSFIPEPKSSC----YNTH--------------------------EKRIYQSN------- 333

  Fly   419 AWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNA 483
                  .::|||..|..||  .::.|::||.:::..|.::.:.......:|.:|.|    :.|..
Human   334 ------MLNRYLINVTFEG--RNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKD----KSLQM 386

  Fly   484 KYV---RLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHG---------------NNRFE- 529
            ||.   |:.|..|.:::....:.|:.|.|:::::.|   :.|.|               .|:.:
Human   387 KYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESV---DPLSGTCMRNTVPCQKRIVTENKTDE 448

  Fly   530 ----------GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAI 584
                      |:|.|:...::|.:...|:|.||.:|.:|.:   .:|.|:||:||:|.|.|.:|:
Human   449 EPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK---INGTWNGMIGEVVMKRAYMAV 510

  Fly   585 AAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLF 649
            .::||..||..|:|||.||:..|||:|:.:. ..|....:|:.|.|.::||.:....:.||.|..
Human   511 GSLTINEERSEVVDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAV 574

  Fly   650 FVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAA 714
            ||..:.                 .|..::..||:.:.||           ||
Human   575 FVFEYF-----------------SPVGYNRCLADGREPG-----------GP------------- 598

  Fly   715 LQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLIL 778
                                 .|::..:.|............: :|:..:.:|..:.|.||.:|.
Human   599 ---------------------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 642

  Fly   779 ISSYTANLAAFLTVERMVTPINSPEDLAMQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMW 837
            ::|||||||||:..|..|..::...|...|      ...::||:.:|||....|.:...:|..|.
Human   643 LASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMG 707

  Fly   838 EYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCD--TMKVGRNLDTKGFGI 899
            :: |.|      ..|:.:..::..| ..|.:.::....|:..| |.|.  |:..|:...:.|:||
Human   708 KF-NQR------GVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGI 764

  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILI 964
            |....|..|..::||:|.|..:||:.:|...|.  ...|...|: |...|:|.:.|:||:||:|.
Human   765 AIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKN-EVMSSQLDIDNMAGVFYMLG 826

  Fly   965 GGLLVSVFVAILE--------YCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPS 1021
            ..:.:|:...|.|        :||..  ..|...|....:..|:...:.|.:: :...|:|..|:
Human   827 AAMALSLITFICEHLFYWQFRHCFMG--VCSGKPGMVFSISRGIYSCIHGVAI-EERQSVMNSPT 888

  Fly  1022 SAV----------------------PGGMPSS-----HQRSTLTDTMHAKAKLTIQASRDYDN 1057
            :.:                      ..|.|.|     .:.|::.|....:...|....:.|:|
Human   889 ATMNNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNN 951

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.