DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and GRIK3

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	1011	Identity:	329/1011 - (32%)
Similarity:	505/1011 - (49%)	Gaps:	196/1011 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSA-----QPSLTEKIPLGAIFE-------QGTDEVQSAFKYA--MLN 65
            |:|..|       :|:.|.|     ...:...|.:|.|||       |..:..:.||:::  ::|
Human    11 LVWEYW-------AGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIIN 68

  Fly    66 HN---LNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQ 127
            .|   |..::..:::|.    |:..|:|:.::..|:|.:.||.::.|.......:.:.|..|..:
Human    69 RNRTLLPNTTLTYDIQR----IHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALE 129

  Fly   128 MPFVTPWFPEKVLTPSSGFLDFALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQI 189
            :|.:...:....|....   .|.:::.|||   ..||:|.:|:..||....:||...||:|||::
Human   130 VPHIQLRWKHHPLDNKD---TFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQEL 191

  Fly   190 YQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRL 254
            .......|...::..:...|:.|..:     |:::.|.....|:.||...||.|||.|   .:.:
Human   192 IMAPSRYNIRLKIRQLPIDSDDSRPL-----LKEMKRGREFRIIFDCSHTMAAQILKQ---AMAM 248

  Fly   255 GRRT--YHYLLSGLVMDDRW--ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD--PQM 311
            |..|  ||::.:.|   |.:  :.|...:..:|:|||||::.:...|....:.|  :||.  |:.
Human   249 GMMTEYYHFIFTTL---DLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRS 310

  Fly   312 SVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNY 376
            ..|.....:...|||:||||.::...:               ||..|
Human   311 ESGLLDGVMMTDAALLYDAVHIVSVCY---------------QRAPQ------------------ 342

  Fly   377 SASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGD 441
                                      |...:|.|:..|    ||..|.:...::::.:.|||||.
Human   343 --------------------------MTVNSLQCHRHK----AWRFGGRFMNFIKEAQWEGLTGR 377

  Fly   442 IKFN-DDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHV-EFEKNRTYIVTT 504
            |.|| ..|.|.::.|.::.:. ...:.||..|:...||........| .|:| :...||:.||||
Human   378 IVFNKTSGLRTDFDLDIISLK-EDGLEKVGVWSPADGLNITEVAKGR-GPNVTDSLTNRSLIVTT 440

  Fly   505 VLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWD 569
            |||||::|.::  ....|:||:||||||.||...||..||.:||:|||:||.||::...  |.|:
Human   441 VLEEPFVMFRK--SDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDK--GQWN 501

  Fly   570 GMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIW 634
            |||.||:..:||:|:|.:|||..||:.||||||||:||:||:.:||....|.||||:||||.:||
Human   502 GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIW 566

  Fly   635 VSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPP 699
            :.|:.:|:|||.|||.::||||:||.            |.|                    |..|
Human   567 MYVLLAYLGVSCVLFVIARFSPYEWY------------DAH--------------------PCNP 599

  Fly   700 GPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSG 764
            |                             |..|.|.|::.|||||.:.:.||||.:|.|:::|.
Human   600 G-----------------------------SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALST 635

  Fly   765 RIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQ 829
            ||....|:|||||:|||||||||||||||||.:||:|.:|||.||:::||.:..|:|..||::|:
Human   636 RIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK 700

  Fly   830 IGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDT 894
            |....|||.:|:|:....|...:|||:|...:  .||||:||...|||..|. |:..::|..:|:
Human   701 ISTFEKMWAFMSSKPSALVKNNEEGIQRALTA--DYALLMESTTIEYVTQRN-CNLTQIGGLIDS 762

  Fly   895 KGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGI 959
            ||:||.||:||..:|.|.:|:|.|:|..:|..::.||| ..:.|...::.|.  |.|.:..:.||
Human   763 KGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW-RGSGCPEEENKEA--SALGIQKIGGI 824

  Fly   960 FYILIGGLLVSVFVAILEYCFR-----SRDSRSASS 990
            |.:|..||::||.||:.|:.::     .|:.||..|
Human   825 FIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCS 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	104/458 (23%)
		ANF_receptor	55..461	CDD:279440	96/422 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	194/440 (44%)
		Lig_chan	632..967	CDD:278489	127/334 (38%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	107/464 (23%)
		ANF_receptor	55..398	CDD:279440	96/423 (23%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	194/436 (44%)
		Lig_chan	564..832	CDD:278489	127/334 (38%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650