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Protein Alignment GluRIB and GRIK2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	1025	Identity:	347/1025 - (33%)
Similarity:	521/1025 - (50%)	Gaps:	217/1025 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFE------QGTDEVQSAFKYAM--LNHN---L 68
            |||:.:|.|              .|..:..|.|||      .|.:|:  ||::|:  :|.|   |
Human    23 LLWIGYSQG--------------TTHVLRFGGIFEYVESGPMGAEEL--AFRFAVNTINRNRTLL 71

  Fly    69 NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 133
            ..::..::.|.    ||..|:|:.|:..|:|.|.||.::.|.....|.:.:.|..|...:|.:..
Human    72 PNTTLTYDTQK----INLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQT 132

  Fly   134 WFPEKVLTPSSGFLDFALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRP 195
            .:..:|   |.....|.:|:.||:   .:||:|.:||:.|:.:..:||...||:|||
Human   133 RWKHQV---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQ-------- 186

  Fly   196 GNESFQVELVKRISNVSMAIEFLH----------TLEQIGRFENKHIVLDCPTEMAKQILIQHVR 250
                   ||:|..|..::.::...          .|:::.|.:..|::.||..|||..||.|
Human   187 -------ELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQ--- 241

  Fly   251 DLRLGRRT--YHYLLSGLVMDDRW--ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD- 308
            .|.:|..|  |||:.:.|   |.:  :.|...:..:|:|||||::|....|....:.|  :||.
Human   242 ALAMGMMTEYYHYIFTTL---DLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQA 303

  Fly   309 -PQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSD 372
             |:...|.....::..||||||||.|:..|               ||:..|
Human   304 PPKPDSGLLDGFMTTDAALMYDAVHVVSVA---------------VQQFPQ-------------- 339

  Fly   373 GYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEG 437
                                          |...:|.||..|    .|..|.:....:::...||
Human   340 ------------------------------MTVSSLQCNRHK----PWRFGTRFMSLIKEAHWEG 370

  Fly   438 LTGDIKFN-DDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYI 501
            |||.|.|| .:|.|.::.|.|:.:. ...:.|:..|:..:||....::..:.....:...||:.|
Human   371 LTGRITFNKTNGLRTDFDLDVISLK-EEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLI 434

  Fly   502 VTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHG 566
            |||:|||||::.|:  ..:.|:||:||||||.||...|:..||..||:|||:||.||:: ..|:|
Human   435 VTTILEEPYVLFKK--SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQ-DDANG 496

  Fly   567 GWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQ 631
            .|:|||.||:..:||:|:|.:.||..||:|||||||||:|||||:.:||....||||||:||||.
Human   497 QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 561

  Fly   632 EIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLP 696
            :||:.::.:|:|||.|||.::||||:||.            :||                    |
Human   562 DIWMYILLAYLGVSCVLFVIARFSPYEWY------------NPH--------------------P 594

  Fly   697 APPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRS 761
            ..|                             .|..|.|.|::.|||||.:.|.||||.:|.|::
Human   595 CNP-----------------------------DSDVVENNFTLLNSFWFGVGALMQQGSELMPKA 630

  Fly   762 VSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFR 826
            :|.||....|:|||||:|||||||||||||||||.:||:|.:|||.||:::||.:..|:|..||:
Human   631 LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFK 695

  Fly   827 RSQIGLHNKMWEYMNSRKH-VFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGR 890
            :|:|..::|||.:|:||:. |.|.:.:|||:||..|  .||.|:||...|:|..|. |:..::|.
Human   696 KSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGG 757

  Fly   891 NLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSN 955
            .:|:||:|:.||:||..:|.|.:|:|.|:|.|:|..::.|||.... |...:..|.  |.|.:.|
Human   758 LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEA--SALGVQN 819

  Fly   956 VAGIFYILIGGLLVSVFVAILEYCFRSR-----DSRSASSGSGMGLGMGL 1000
            :.|||.:|..||::|||||:.|:.::|:     :.||..|.....|.|.|
Human   820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSL 869

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.