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Protein Alignment GluRIB and GRIK1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	978	Identity:	331/978 - (33%)
Similarity:	506/978 - (51%)	Gaps:	192/978 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LGAIFEQGTDE----VQSAFKYAMLNHNLN-----VSSRRFELQAYVDVINTADAFKLSRLICNQ 99
            :|.|||...:|    .:.|||:|:.:.|.|     .::..:::|.    ||..|:|:.||..|:|
Human    39 IGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR----INLFDSFEASRRACDQ 99

  Fly   100 FSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTPSSGFLD-FALSMRPDY---HQ 159
            .:.||.::.|.....|...:.|..|..::|.: |.|     ..||....| |.:::.|||   .:
Human   100 LALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW-----KHPSVDNKDLFYINLYPDYAAISR 159

  Fly   160 AIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQI 224
            ||:|.:.:|.|:.:..:|:...||:|||::.:.  |...:.::::.:..|....|...|..:::.
Human   160 AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKA--PSRYNIKIKIRQLPSGNKDAKPLLKEMKKG 222

  Fly   225 GRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLSGLVMDDRW--ESEIIEFGAINIT 285
            ..|   :::.||..|.|.:||.|   .|.:|..|  |||..:.|   |.:  :.|:..:..:|:|
Human   223 KEF---YVIFDCSHETAAEILKQ---ILFMGMMTEYYHYFFTTL---DLFALDLELYRYSGVNMT 278

  Fly   286 GFRIVDTNRRLVREFYDSW--KRLD--PQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKP 346
            |||:::.:...|....:.|  :||.  |:...|.....::.:||||||||:::..|
Human   279 GFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA--------- 334

  Fly   347 DQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCN 411
                   ..|:..|.|:                                           :|.|:
Human   335 -------SHRASQLTVS-------------------------------------------SLQCH 349

  Fly   412 TAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-DDGRRVNYTLHVV----EMTVNSA------ 465
            ..|    .|..|.:....:::...:||||.|.|| .:|.|.::.|.::    |.|..:|
Human   350 RHK----PWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKH 410

  Fly   466 ----MVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNN 526
                ..|:..||.::||...::...:.....:...|||.||||:|||||:|.::  ..:.|:||:
Human   411 LYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRK--SDKPLYGND 473

  Fly   527 RFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITA 591
            ||||||.||...|:..||..|:::||.||.||::...  |.|:|||.||:...||:|:|.:|||.
Human   474 RFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDK--GEWNGMVKELIDHRADLAVAPLTITY 536

  Fly   592 ERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSP 656
            .||:|||||||||:|||||:.:||....||||||:||||.:||:.|:.:.:|||.|||.::||:|
Human   537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTP 601

  Fly   657 HEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSA 721
            :||.            :||                    |..|
Human   602 YEWY------------NPH--------------------PCNP---------------------- 612

  Fly   722 GSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANL 786
                   .|..|.|.|::.|||||.:.|.||||.:|.|:::|.||....|:|||||:||||||||
Human   613 -------DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670

  Fly   787 AAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKH-VFVPT 850
            |||||||||.:||:|.:|||.||:::||.:..|||..||::|:|..:.|||.:|:||:. ..|..
Human   671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 735

  Fly   851 YDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAV 915
            .||||:||..:  .||||:||...|||..|. |:..::|..:|:||:|:.||:||..:|.|.:|:
Human   736 SDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797

  Fly   916 LTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980
            |.|:|.|:|..::.|||.... |....:.|.  |.|.:.|:.|||.:|..||::||||||.|:.:
Human   798 LQLQEEGKLHMMKEKWWRGNG-CPEEDNKEA--SALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859

  Fly   981 RSR 983
            :||
Human   860 KSR 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.