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Protein Alignment GluRIB and GRIA3

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_000819.4	Gene:	GRIA3 / 2892	HGNCID:	4573	Length:	894	Species:	Homo sapiens

Alignment Length:	960	Identity:	410/960 - (42%)
Similarity:	549/960 - (57%)	Gaps:	160/960 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPLGAIFEQGTDEVQSAFKYA--MLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGV 104
            |.:|.:|.:.|.:..|||::|  :.|.|.|.:.:.|.|..:||.::::::|.::...|:||||||
Human    34 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGV 98

  Fly   105 YSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYG 169
            |::.|.....|.:||.|:.......||||.|      |:...:.|.:.|||....||:..:..|.
Human    99 YAIFGFYDQMSMNTLTSFCGALHTSFVTPSF------PTDADVQFVIQMRPALKGAILSLLGHYK 157

  Fly   170 WRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVL 234
            |.|.:||||:..|...||.|.:.....|  :|| ..:.:.|:....||...:|::.|.:.|..::
Human   158 WEKFVYLYDTERGFSILQAIMEAAVQNN--WQV-TARSVGNIKDVQEFRRIIEEMDRRQEKRYLI 219

  Fly   235 DCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLV 297
            ||..|....||.|.|   .||:  |.|||:|:.|...|.....::..|| |||||:||:....:|
Human   220 DCEVERINTILEQVV---ILGKHSRGYHYMLANLGFTDILLERVMHGGA-NITGFQIVNNENPMV 280

  Fly   298 REFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMV 362
            ::|...|.|||.:....|....:...:||.:||:.|:.|||..:.|::.|     |.||
Human   281 QQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVD-----VSRR------ 334

  Fly   363 AQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC--NTAKGWVNAWEHGDK 425
                                                ||.|      ||  |.|.    .|..|..
Human   335 ------------------------------------GSAG------DCLANPAV----PWSQGID 353

  Fly   426 ISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRP 490
            |.|.|:.|:::|:||:|:|:..|||.|||:.|.||.|:.:. |...||:          |.|..|
Human   354 IERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSR-KAGYWNE----------YERFVP 407

  Fly   491 HVEFE--------KNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINY 547
            ..:.:        :|||.:|||:||.||:|.|:  ..|:|.||.|:||||.|||..:||.:.|.|
Human   408 FSDQQISNDSASSENRTIVVTTILESPYVMYKK--NHEQLEGNERYEGYCVDLAYEIAKHVRIKY 470

  Fly   548 ELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMI 612
            :|.:|.||.||:...... .|:|||||||...||||:|.:|||..||.|||||||||||||||||
Human   471 KLSIVGDGKYGARDPETK-IWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI 534

  Fly   613 KKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLV--QQQPQQSQSPDPH 675
            |||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||.|.  .::|:..||
Human   535 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQS---- 595

  Fly   676 AHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVW 740
                                  ||.||                                |||.::
Human   596 ----------------------PPDPP--------------------------------NEFGIF 606

  Fly   741 NSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDL 805
            ||.||||.||||||||:||||:||||....|:|||||:||||||||||||||||||:||.|.|||
Human   607 NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 671

  Fly   806 AMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLV 869
            |.|||:.||||..|||.:|||||:|.::.|||.||.|.: .||..|..:|:.|||.||||:|.|:
Human   672 AKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLL 736

  Fly   870 ESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYE 934
            ||..|||:..|:||||||||.|||:||:|:|||.||||::.:|||||.|.|.|.|.||:|||||:
Human   737 ESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD 801

  Fly   935 KAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSR 983
            |.|| |...|.:...|.||||||||:||||:|||.:::.||::|:|::||
Human   802 KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSR 851

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.