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Protein Alignment GluRIB and GRIA2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	995	Identity:	410/995 - (41%)
Similarity:	559/995 - (56%)	Gaps:	194/995 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQA 79
            :||         |...|||     :..|.:|.:|.:|.|:..|||:..|    :..|:..|.|..
Human    14 VLW---------GLIFGVS-----SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTP 60

  Fly    80 YVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSS 144
            ::|.:..|::|.::...|:|||||||::.|.....|.:|:.|:..|..:.|:||.|      |:.
Human    61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTD 119

  Fly   145 GFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK--R 207
            |...|.:.||||...|::..|::|.|.|..|||||..||..||.:...  ...:.:||..:.  .
Human   120 GTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS--AAEKKWQVTAINVGN 182

  Fly   208 ISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDD 270
            |:|......:....:.:...:.:.::|||..:....|:.|.:   .:|:  :.|||:::.|...|
Human   183 INNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVI---TIGKHVKGYHYIIANLGFTD 244

  Fly   271 RWESEI--IEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFV 333
               .::  |:||..|::||:|||.:..||.:|.:.|..|:.:...||...:|...:||.||||.|
Human   245 ---GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQV 306

  Fly   334 LVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSG 398
            :.|||.. |||:    |..:.||                           ||.|
Human   307 MTEAFRN-LRKQ----RIEISRR---------------------------GNAG----------- 328

  Fly   399 GSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT 461
                      ||  |.|.    .|..|.:|.|.|::|::|||:|:|||:.:|:|:|||::::|:.
Human   329 ----------DCLANPAV----PWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379

  Fly   462 VNSAMVKVAEW----------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPY 510
            .|... |:..|                ||.:||:                 |:|.:|||:||.||
Human   380 TNGPR-KIGYWSEVDKMVVTLTELPSGNDTSGLE-----------------NKTVVVTTILESPY 426

  Fly   511 IMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGEL 575
            :|:|:  ..|.|.||.|:||||.|||..:||..|..|:|.:|.||.||:..:... .|:||||||
Human   427 VMMKK--NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGEL 488

  Fly   576 VRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640
            |..:||||||.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:
Human   489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553

  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPG 705
            |||||:|||.||||||:||                 |.|:..:                     |
Human   554 YIGVSVVLFLVSRFSPYEW-----------------HTEEFED---------------------G 580

  Fly   706 AQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAAS 770
            .:|                    .||...|||.::||.||||.||||||||:||||:||||....
Human   581 RET--------------------QSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625

  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNK 835
            |:|||||:||||||||||||||||||:||.|.|||:.|||:.||||..|||.:|||||:|.:.:|
Human   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK 690

  Fly   836 MWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGI 899
            ||.||.|.: .|||.|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:||
Human   691 MWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755

  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYIL 963
            |||.||:|:.|:|||||.|.|.|.|.||:|||||:|.||.....| :...|.||||||||:||||
Human   756 ATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYIL 820

  Fly   964 IGGLLVSVFVAILEYCFRSR 983
            :|||.:::.||::|:|::||
Human   821 VGGLGLAMLVALIEFCYKSR 840

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.