DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Ir41a

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	141/818 - (17%)
Similarity:	238/818 - (29%)	Gaps:	320/818 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 DDRWE------SEIIEFGAINITGF------RIVDTNRRLVREFYDSWKRLDP-QMSVGAGRESI 320
            :|::|      |:.|.|..|||..|      .|:||..: .:|..:....||. .:.:....|..
  Fly    29 NDKFEFQLLHKSDYISFVGINIKSFDDNGGHYIIDTGLK-KKELQNKHLFLDELVIKIIISIEVT 92

  Fly   321 SAQAALMYDA-VFVLVEAFNK------------------ILRKKPDQFRNNVQRRSQTLMVAQAA 366
            ..:..:::|. :...|.||||                  |..:.|:...:..:.:...|.|.:..
  Fly    93 HCETFVVFDKDIDRFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDH 157

  Fly   367 ASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDK---ISR 428
            :|.||                                    .|..|.|......|:..:   :.|
  Fly   158 SSASS------------------------------------FDIKTNKFVGRKAENPSQMILVDR 186

  Fly   429 YLRKVEI----EGLTGDIKFNDDGRRV--------NYTLHVVEMTVNSAMVKVAEWNDDAGLQPL 481
            ||...:.    :.|..|...|..||.|        .||:....|:.|:         .|.|:..
  Fly   187 YLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNMSTNA---------QDMGVSG- 241

  Fly   482 NAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGIN 546
                       |.:....||..|   |..|:|                .:|:.          .|
  Fly   242 -----------ESDFKNVYIDGT---ETRIVL----------------NFCEQ----------FN 266

  Fly   547 YELRLVKDGNYGSEKSSAHGGW---------DGMVGELVRKEADIAIAAMTITAERERVIDFSKP 602
            ..:::         .|||...|         ||.:|.|:.::|||.|.||....|....:|.|..
  Fly   267 CTIQI---------DSSAANDWGKVYPNMSGDGALGMLINRKADICIGAMYSWYEDYTYLDLSMY 322

  Fly   603 FMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYI--GVSIVLFFVSRFSPHEWRLVQQQ 665
            .:..||:.::..|::.|..... :.|..:.:|.:::....  ...:||
  Fly   323 LVRSGITCLVPAPLRLTSWYLP-LEPFKETLWAAILLCLCAEATGLVL----------------- 369

  Fly   666 PQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSS 730
                      |:..:.|....||.             ..|..|.
  Fly   370 ----------AYKSEQALYVLPGY-------------REGWWTC--------------------- 390

  Fly   731 SAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERM 795
                ..|.|..:|    ..|:.|..:....|::.|:...:.|...||:.|.|...||:.||:..|
  Fly   391 ----TSFGVCTTF----KLFISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSM 447

  Fly   796 VTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRN 860
                    |.|..|..:..          |.|.|...:::.|                 :..:|.
  Fly   448 --------DEAADTVTRLR----------FHRLQWAANSEAW-----------------VSAIRA 477

  Fly   861 SKGKYALLVESPKNEYVNAREPC------DTMKVGRNLDTKGFG---IATPLGS----------- 905
            |  ..||:.:...|.::.:.:..      ..|::|..::...||   |...||.
  Fly   478 S--DEALVKDILYNFHIYSDDELLRLAQDQHMRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKD 540

  Fly   906 ---------------ALKDPINLAVLTLKENGELIKLRNKWW----------------YEKAECS 939
                           .|.|.:|..:.:...:|     .:|:|                .::....
  Fly   541 DIYFQYTVAFVPRLWPLLDKLNTLIYSWHSSG-----FDKYWEYRVVADNLNLKIQQQVQETMTG 600

  Fly   940 THKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILE 977
            |...|..   .|.:||.||...:.|.|..::....:||
  Fly   601 TKDIGPV---PLGMSNFAGFIIVWILGSAIATLTFLLE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	47/255 (18%)
		ANF_receptor	55..461	CDD:279440	44/238 (18%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	81/502 (16%)
		Lig_chan	632..967	CDD:278489	59/387 (15%)
Ir41a	NP_995744.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840