Protein Alignment GluRIB and Grin2c

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 1269
• Identity: 279/1269 - (21%)
• Similarity: 461/1269 - (36%)
• Gaps: 361/1269 - (28%)

  Fly    25 GGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAML---------NHNLNVSSRRF----- 75
            ||..|      |:|.....|||....|..:.:.|...|::         .....::|:.|
  Rat    15 GGALG------PALLLTSLLGAWARLGAGQGEQAVTVAVVFGSSGPLQTQARTRLTSQNFLDLPL 73

  Fly    76 ELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPFVT-P 133
            |:|.....:|..:...:...||...  |...:.|.|..|:.||      |...|:...:|.:: .
  Rat    74 EIQPLTVGVNNTNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSIS 136

  Fly   134 WFPEKVLT---PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRP 195
            .....|||   |.|.||...:|:.... |.:...::.|.|...              .:...|.|
  Rat   137 GGSAVVLTPKEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAF--------------AVITSLHP 186

  Fly   196 GNESFQVELVKRISNVS-MAIEFLHTLE-QIG----RFENKHIV--LDCPTEMAKQILIQHVRDL 252
            |:..| :|.|:.:::.| ::...|..|. ::|    |...:.::  :|.|      :|:.:.
  Rat   187 GHALF-LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAP------VLVAYC--- 241

  Fly   253 RLGRRTYHYLLSGLVMDDRWESEII--EFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGA 315
                             .|.|:|::  |.....:.|...|             |  |.|.:::|:
  Rat   242 -----------------SREEAEVLFAEAAQAGLVGPGHV-------------W--LVPNLALGS 274

  Fly   316 GRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASG 380
               :.:..||.....:.|:.|::...||:|                |....|..:...::|...
  Rat   275 ---TDAPPAAFPVGLISVVTESWRLSLRQK----------------VRDGVAILALGAHSYRRQ- 319

  Fly   381 GGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN 445
                               .|.:.:.|.||.:..|.|:...  :...|:|..|..||  .|..|:
  Rat   320 -------------------YGTLPAPAGDCRSHPGPVSPAR--EAFYRHLLNVTWEG--RDFSFS 361

  Fly   446 DDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGL----QPLNAKY-VRLRPHVEFEKNRTYIVTTV 505
            ..|..|..|:.|:.:..:.....|..|  |.|:    .|:..:| ..|:|.|:   :|...|.|:
  Rat   362 PGGYLVRPTMVVIALNRHRLWEMVGRW--DHGVLYMKYPVWPRYSTSLQPVVD---SRHLTVATL 421

  Fly   506 LEEPYIMLKQVAFGE----------KLHGNNRF-------------EGYCKDLADLLAKELGINY 547
            .|.|:::::....|.          :...|:.|             :|:|.|:...|||.:..:|
  Rat   422 EERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSY 486

  Fly   548 ELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMI 612
            :|.||.:|.:|..   ..|.|:||:||:..|.||:||.::||..||..:||||.||:..|||:|:
  Rat   487 DLYLVTNGKHGKR---VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMV 548

  Fly   613 KKPVKQTPGVFSFMNPLSQEIWVSV-IFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHA 676
            .:. ..|....:|:.|.|..:||.: :.....|:|.:|....||                  |.:
  Rat   549 SRS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFS------------------PVS 594

  Fly   677 HHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWN 741
            :::.|...:.||           ||                                  .|::..
  Rat   595 YNQNLTKGKKPG-----------GP----------------------------------SFTIGK 614

  Fly   742 SFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDL 805
            |.|...|........: :||..:.:|....|.||.:|.::|||||||||:..|:.:..::...|.
  Rat   615 SVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDK 679

  Fly   806 AMQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGK 864
            ..|      ...::||:.:|||....|.:...:|..|.:: |.|      :.::.:..::  .||
  Rat   680 KFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKF-NQR------SVEDALTSLK--MGK 735

  Fly   865 Y-ALLVESPKNEYVNAR-EPCD--TMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELI 925
            . |.:.::....|:..: |.|.  |:..|:...|.|:|||....|..|..|:||:|.|..:||..
  Rat   736 LDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQ 800

  Fly   926 KLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASS 990
            ||...|.  ...|...|: |...|:|.:.|:||:||:|:..:.:::.|...|:....:...|..:
  Rat   801 KLETVWL--SGICQNEKN-EVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPN 862

  Fly   991 GSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDY 1055
            .|.:...:    ..|.|.....||...| ||.|.|   ||.   ....|:..|.....:||:||.
  Rat   863 SSQLDFLL----AFSRGIYSCFNGVQSL-PSPARP---PSP---DLTADSAQANVLKMLQAARDM 916

  Fly  1056 ---------------------DNGRVGYLNCA---SLQYYPPAQLSAT---PPDAGDSLHMNAHG 1093
                                 :|.||.....:   |....||.|.|.:   ||..|
  Rat   917 VNTADVSSSLDRATRTIENWGNNRRVPAPTASGPRSSTPGPPGQPSPSGWGPPGGG--------- 972

  Fly  1094 QVXHEHAQESRLXRTPCA-----------------PTIRRIMANSRQETEKMMGGGHGGT-VTVS 1140
                         |||.|                 |.:.|.......:....:..||.|. |:.|
  Rat   973 -------------RTPLARRAPQPPARPATCGPPLPDVSRPSCRHASDARWPVRVGHQGPHVSAS 1024

  Fly  1141 ----------VPATCSSSMNGSHEGSLALSPSSG 1164
                      :||.|       |..|...:..||
  Rat  1025 ERRALPERSLLPAHC-------HYSSFPRAERSG 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	88/474 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	120/475 (25%)
		Lig_chan	630..966	CDD:459656	83/347 (24%)
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	84/459 (18%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	121/477 (25%)
		NMDAR2_C	850..>925	CDD:463148	19/85 (22%)