DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIB and Grin2b

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:1165 Identity:249/1165 - (21%)
Similarity:432/1165 - (37%) Gaps:336/1165 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 CLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIP--LG-AIFEQGT-DEVQSAFKYAMLN---H 66
            |..|.|  ||..:.       :.||...:.::|.|  :| |:...|| |||  |.|.|...   |
  Rat     7 CCSPKF--WLVLAV-------LAVSGSKARSQKSPPSIGIAVILVGTSDEV--AIKDAHEKDDFH 60

  Fly    67 NLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV 131
            :|:|.. |.||.|    :|..|...:...||:..|.  ..:.|.|..|..|       ...:..:
  Rat    61 HLSVVP-RVELVA----MNETDPKSIITRICDLMSD--RKIQGVVFADDTD-------QEAIAQI 111

  Fly   132 TPWFPEKVLTP-----------------SSGFLDFALSMRPDYHQA--IIDTIQFYGWRKIIYLY 177
            ..:...:.|||                 ||.|..|..|:.   .||  :::.::.|.|    |::
  Rat   112 LDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIE---QQASVMLNIMEEYDW----YIF 169

  Fly   178 DSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL--------------EQIGRFE 228
                      .|.....||.:.|..::...|.|..:..|....|              .|:.:.:
  Rat   170 ----------SIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQ 224

  Fly   229 NKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEF--GAINITGFRIVD 291
            :..|:|.|..|.|..| .:....:.|....|.:::..||..|. ::...||  |.|:::      
  Rat   225 SPIILLYCTKEEATYI-FEVANSVGLTGYGYTWIVPSLVAGDT-DTVPSEFPTGLISVS------ 281

  Fly   292 TNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRR 356
                     ||.|....|               |.:.|.:.::..|.:.:|              
  Rat   282 ---------YDEWDYGLP---------------ARVRDGIAIITTAASDML-------------- 308

  Fly   357 SQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWE 421
            |:...:.:..:|.    ||..                          ..|....|          
  Rat   309 SEHSFIPEPKSSC----YNTH--------------------------EKRIYQSN---------- 333

  Fly   422 HGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYV 486
               .::|||..|..||  .::.|::||.:::..|.::.:.......:|.:|.|    :.|..||.
  Rat   334 ---MLNRYLINVTFEG--RNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKD----KSLQMKYY 389

  Fly   487 ---RLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHG---------------NNRFE---- 529
               |:.|..|.:::....:.|:.|.|:::::.|   :.|.|               .|:.:    
  Rat   390 VWPRMCPETEEQEDDHLSIVTLEEAPFVIVESV---DPLSGTCMRNTVPCQKRIISENKTDEEPG 451

  Fly   530 -------GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAM 587
                   |:|.|:...::|.:...|:|.||.:|.:|.:   .:|.|:||:||:|.|.|.:|:.::
  Rat   452 YIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKK---INGTWNGMIGEVVMKRAYMAVGSL 513

  Fly   588 TITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVS 652
            ||..||..|:|||.||:..|||:|:.:. ..|....:|:.|.|.::||.:....:.||.|..||.
  Rat   514 TINEERSEVVDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVF 577

  Fly   653 RFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQA 717
            .:.                 .|..::..||:.:.||           ||                
  Rat   578 EYF-----------------SPVGYNRCLADGREPG-----------GP---------------- 598

  Fly   718 ALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISS 781
                              .|::..:.|............: :|:..:.:|..:.|.||.:|.::|
  Rat   599 ------------------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 645

  Fly   782 YTANLAAFLTVERMVTPINSPEDLAMQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYM 840
            ||||||||:..|..|..::...|...|      ...::||:.:|||....|.:...:|..|.:: 
  Rat   646 YTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKF- 709

  Fly   841 NSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCD--TMKVGRNLDTKGFGIATP 902
            |.|      ..|:.:..::..| ..|.:.::....|:..| |.|.  |:..|:...:.|:|||..
  Rat   710 NQR------GVDDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQ 767

  Fly   903 LGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGL 967
            ..|..|..::||:|.|..:||:.:|...|.  ...|...|: |...|:|.:.|:||:||:|...:
  Rat   768 KDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICHNEKN-EVMSSQLDIDNMAGVFYMLGAAM 829

  Fly   968 LVSVFVAILE--------YCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAV 1024
            .:|:...|.|        :||..  ..|...|....:..|:...:.|.:: :...|:|..|::.:
  Rat   830 ALSLITFICEHLFYWQFRHCFMG--VCSGKPGMVFSISRGIYSCIHGVAI-EERQSVMNSPTATM 891

  Fly  1025 ----------------------PGGMPSS-----HQRSTLTDTMHAKAKLTIQASRDYDN 1057
                                  ..|.|.|     .:.|::.|....:...|....:.|:|
  Rat   892 NNTHSNILRLLRTAKNMANLSGVNGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNN 951

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 91/476 (19%)
ANF_receptor 55..461 CDD:279440 81/443 (18%)
PBP2_iGluR_AMPA 497..938 CDD:270433 113/476 (24%)
Lig_chan 632..967 CDD:278489 79/344 (23%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 93/487 (19%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 114/478 (24%)
HisJ <459..>542 CDD:223904 34/86 (40%)
Lig_chan 557..829 CDD:278489 79/344 (23%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 1/18 (6%)