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Protein Alignment GluRIB and Grin2a

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	1312	Identity:	258/1312 - (19%)
Similarity:	450/1312 - (34%)	Gaps:	418/1312 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RFGLKLSCLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYA-MLN 65
            |.|.....:.|:.|:|..             .||.:..||.|             .|...| :|.
  Rat     3 RLGYWTLLVLPALLVWRD-------------PAQNAAAEKGP-------------PALNIAVLLG 41

  Fly    66 HNLNVSSRRFE----------LQAYVDVI----NTADAFKLSRLICNQFS--------------- 101
            |:.:|:.|...          |...|:|:    |..|...|...:|:..|
  Rat    42 HSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQ 106

  Fly   102 RGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQ 166
            ..|..||..:|..:|..:........|.....       .|:|.|..|..|::   .||.:
  Rat   107 EAVAQMLDFISSQTFIPILGIHGGASMIMADK-------DPTSTFFQFGASIQ---QQATV---- 157

  Fly   167 FYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK-------------RISNVSMAIEFL 218
               ..||:..||.|     :..:...:.||...| :..:|             .:..:..:.|..
  Rat   158 ---MLKIMQDYDWH-----VFSLVTTIFPGYRDF-ISFIKTTVDNSFVGWDMQNVITLDTSFEDA 213

  Fly   219 HTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEII--EF-- 279
            .|..|:.:..:..|:|.|..:.| .:::...|.|.|....:.:::..||..:   :|:|  ||
  Rat   214 KTQVQLKKIHSSVILLYCSKDEA-VLILSEARSLGLTGYDFFWIVPSLVSGN---TELIPKEFPS 274

  Fly   280 GAINITGFRIVDTNRRLVREFYDSWK-RLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILR 343
            |.|:::               ||.|. .|:.::..|.|         ::..|...::|.|:.|..
  Rat   275 GLISVS---------------YDDWDYSLEARVRDGLG---------ILTTAASSMLEKFSYIPE 315

  Fly   344 KKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRAL 408
            .|...:....:..:....:.|...:.:.||
  Rat   316 AKASCYGQAEKPETPLHTLHQFMVNVTWDG----------------------------------- 345

  Fly   409 DCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWN 473
                                           .|:.|.::|.:|:..|.|:.:..:....||.:|.
  Rat   346 -------------------------------KDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWE 379

  Fly   474 DDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEE-PYIMLKQV--------------------- 516
            :.. |...:|.:.|.:...:.|.:..::....||| |:::::.:
  Rat   380 NQT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKIN 443

  Fly   517 -AFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEA 580
             :..|.::.....:|:|.|:...|::.:...|:|.||.:|.:|.:.::.   |:||:||:|.:.|
  Rat   444 NSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV---WNGMIGEVVYQRA 505

  Fly   581 DIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVS 645
            .:|:.::||..||..|:|||.||:..|||:|:.:. ..|....:|:.|.|..:||.:....:.||
  Rat   506 VMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVMMFVMLLIVS 569

  Fly   646 IVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAA 710
            .:..||..:.                 .|..::..||..:           ||.||
  Rat   570 AIAVFVFEYF-----------------SPVGYNRNLAKGK-----------APHGP--------- 597

  Fly   711 GAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFF 774
                                     .|::..:.|............: :|:..:.:|..:.|.||
  Rat   598 -------------------------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFF 637

  Fly   775 TLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQY------GTLLHGSTWDFFRRSQIGLH 833
            .:|.::|||||||||:..|..|..:....|...|....|      ||:.:|||....|.:...:|
  Rat   638 AVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMH 702

  Fly   834 NKMWEYMNSRKHVFVPTYDEGIK--RVRNSKGKY-ALLVESPKNEYVNAR-EPCDTMKVGRN--L 892
            ..|..: |.|          |::  .|....||. |.:.::....|...| |.|..:.:|..  .
  Rat   703 QYMTRF-NQR----------GVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIF 756

  Fly   893 DTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVA 957
            .|.|:|||...||..|..|:||:|....:||:.:|...|.  ...|...|: |...|:|.:.|:|
  Rat   757 ATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHNEKN-EVMSSQLDIDNMA 818

  Fly   958 GIFYILIGGLLVSVFVAI--------LEYCF-------------------------------RSR 983
            |:||:|...:.:|:...|        |.:||                               :|.
  Rat   819 GVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSP 883

  Fly   984 DSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLT 1048
            |.....|.|.| |.: |....:..::...|.|.|..|..|              ||.:...:.:.
  Rat   884 DFNLTGSQSNM-LKL-LRSAKNISNMSNMNSSRMDSPKRA--------------TDFIQRGSLIV 932

  Fly  1049 IQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDAGDSL---HMNAHGQVXHEHAQESRLXRTPC 1110
            ...|   |.|.:.|.:..|.|             ..||:   :||
  Rat   933 DMVS---DKGNLIYSDNRSFQ-------------GKDSIFGDNMN-------------------- 961

  Fly  1111 APTIRRIMANSRQE--TEKMMGGGHGGTVTVSVPATCSSSMNGSHEGSLALSPSSGSATLMRHSP 1173
              .::..:||..::  :..:..|.|..|:..|.|.|...:::...:|      :|....|.:.|.
  Rat   962 --ELQTFVANRHKDNLSNYVFQGQHPLTLNESNPNTVEVAVSTESKG------NSRPRQLWKKSM 1018

  Fly  1174 D------INQHP 1179
            :      :||:|
  Rat  1019 ESLRQDSLNQNP 1030

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.