Protein Alignment GluRIB and Grik5

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 1138
• Identity: 350/1138 - (30%)
• Similarity: 522/1138 - (45%)
• Gaps: 279/1138 - (24%)

  Fly    34 AQPS--LTEKIPLGAIFEQGT-----DEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91
            |.||  :...:.:.||.:..|     :.:..|.....:|..:.|.::     |.|:|    |.|:
  Rat    14 ANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK-----ARVEV----DIFE 69

  Fly    92 LSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFL 147
            |.|        .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  ||...:|
  Rat    70 LQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYL 131

  Fly   148 DFA-LSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRI 208
            .|| :|:.|   |...|:...::.:.:.....:....:.||||:::.:|.....|:..|.::...
  Rat   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDS 196

  Fly   209 SNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLS--------- 264
            .:.:      ..|::|...:...|::|....:: .::::...:|.:....|.|:|:
  Rat   197 RDPT------PLLKEIRDDKVSTIIIDANASIS-HLVLRKASELGMTSAFYKYILTTMDFPILHL 254

  Fly   265 -GLVMDDRWESEIIEFGAINITGFRIVDTNR----RLVREFYDSWKRLDPQMSVGAGRESISA-- 322
             |:|.|           :.||.||.:.:|:.    ..||....||            ||:..|
  Rat   255 DGIVED-----------SSNILGFSMFNTSHPFYPEFVRSLNMSW------------RENCEAST 296

  Fly   323 ------QAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGG 381
                  .||||:|||.|:|.|..::             .|||.:.|
  Rat   297 YPGPALSAALMFDAVHVVVSAVREL-------------NRSQEIGV------------------- 329

  Fly   382 GGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFND 446
                                    :.|.|.:|    |.|.||..:..|||.||.:||||.::||.
  Rat   330 ------------------------KPLACTSA----NIWPHGTSLMNYLRMVEYDGLTGRVEFNS 366

  Fly   447 DGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYI 511
            .|:|.||||.::|.: .....::..|..:..| .:||..:.:... :...|:|.:|||:||.||:
  Rat   367 KGQRTNYTLRILEKS-RQGHREIGVWYSNRTL-AMNATTLDINLS-QTLANKTLVVTTILENPYV 428

  Fly   512 MLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
            | ::..| :.|.||.||||:|.|:...||:.|...|.||||:||.||:.:  .:|.|.||||||:
  Rat   429 M-RRPNF-QALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPE--PNGSWTGMVGELI 489

  Fly   577 -RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640
             |::||:|:||.|||||||:|||||||||:|||||:.:..:.:.||.|||::|.|..:|:.::.:
  Rat   490 NRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLA 554

  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPG 705
            |:.||.|||..:|.||:||    ..|.......||
  Rat   555 YLAVSCVLFLAARLSPYEW----YNPHPCLRARPH------------------------------ 585

  Fly   706 AQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAAS 770
                                      .:.|::::.||.||.:..|||||.::.||::|.|..:..
  Rat   586 --------------------------ILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV 624

  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNK 835
            |:.||||:||||||||||||||:||..|:.|.:|||.||.::|||:..|||..||:.|:...:.:
  Rat   625 WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQR 689

  Fly   836 MWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGI 899
            ||.||.|:: .|||.:.:|||.||.||  :||.|:||..||| :.|..|:..::|..|||||:||
  Rat   690 MWNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGI 751

  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILI 964
            ..||||..:|.|.||:|.|:||..|..|:.||| |...|...:|...  ..|.:.|:.|||.:||
  Rat   752 GMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPKEEDHRA--KGLGMENIGGIFVVLI 813

  Fly   965 GGLLVSVFVAILEYCFRSRDSRSASS--------------------------------GSGMGL- 996
            .||:::||||::|:.:.:|  |||.|                                |....|
  Rat   814 CGLIIAVFVAVMEFIWSTR--RSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALL 876

  Fly   997 ------GMGLGGGM-----SGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQ 1050
                  .|.|..|.     :||..|...|...|......||| |.....:..|.....:....||
  Rat   877 SLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGG-PRPQAPTPCTHVRVCQECRRIQ 940

  Fly  1051 ASRDYDNGRVGYLNCASLQYYPPAQLSATPPDA 1083
            |.|            ||....||..| .||.:|
  Rat   941 ALR------------ASGAGAPPRGL-GTPAEA 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	105/474 (22%)
		ANF_receptor	55..461	CDD:279440	101/440 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	191/442 (43%)
		Lig_chan	632..967	CDD:278489	126/335 (38%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	106/481 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	190/438 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650