DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and Grin3a

DIOPT Version :10

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_001263284.1 Gene:Grin3a / 242443 MGIID:1933206 Length:1135 Species:Mus musculus


Alignment Length:613 Identity:136/613 - (22%)
Similarity:250/613 - (40%) Gaps:146/613 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   423 GDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMV--------------KVAEWN 473
            |..:||:|......||:|.||....         .:..:.|:..:              ::..|.
Mouse   430 GQYLSRFLANTTFRGLSGSIKVKGS---------TIVSSENNFFIWNLQYDPMGKPMWTRLGSWQ 485

  Fly   474 D-----DAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQV----------------- 516
            .     |:|:.|..|:  |.:.|..........|.|::|.|::..::|                 
Mouse   486 GGRIVMDSGIWPEQAQ--RHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMT 548

  Fly   517 -------AFGEKLHGNN-----RFE----GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAH 565
                   :....||.:|     :|:    |||.||.:.||:::..:::|.:|.||.||:.|   :
Mouse   549 NDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWK---N 610

  Fly   566 GGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLS 630
            |.|.|:||:|:...|::|:.:.:|...|.:||||:.||.|..:.|:::......| :.:||.||.
Mouse   611 GHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLH 674

  Fly   631 QEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPL 695
            ..:|:.:   ::.:.|...|::.:   ||:                        .|.|:      
Mouse   675 WTMWLGI---FVALHITAIFLTLY---EWK------------------------SPFGM------ 703

  Fly   696 PAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR 760
                   ||..:......:..:||                  :|..:..|...|.::     .|:
Mouse   704 -------TPKGRNRNKVFSFSSAL------------------NVCYALLFGRTAAIK-----PPK 738

  Fly   761 SVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQ---YGTLLHGSTW 822
            ..:||.....|..|.:..:|:|||||||.:..|::...::...|..:....|   :||:...|..
Mouse   739 CWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAE 803

  Fly   823 DFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY-ALLVESPKNEY-VNAREPCDT 885
            |:.|:|...:|    |||   :...||...:|::.::|...|. |.:::....:| |:....|..
Mouse   804 DYVRQSFPEMH----EYM---RRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861

  Fly   886 MKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSE 950
            :.||:....:|:||..|..|.|...|:..:...|.:|.:..|.:| ||:...|.......|...:
Mouse   862 LTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDK-WYKVVPCGKRSFAVTETLQ 925

  Fly   951 LSLSNVAGIFYILIGGLLVSVFVAILEY 978
            :.:.:.:|:|.:|..|..:|:...|.|:
Mouse   926 MGIKHFSGLFVLLCIGFGLSILTTIGEH 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..480 CDD:380603 13/75 (17%)
PBP2_iGluR_AMPA 497..938 CDD:270433 110/478 (23%)
Lig_chan 630..966 CDD:459656 69/340 (20%)
Grin3aNP_001263284.1 PBP1_iGluR_NMDA_NR3 40..496 CDD:380600 13/74 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 108/473 (23%)
Lig_chan 674..941 CDD:459656 69/340 (20%)
PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7 951..987 1/3 (33%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1082..1115
Blue background indicates that the domain is not in the aligned region.

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