DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grin3a

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	613	Identity:	136/613 - (22%)
Similarity:	250/613 - (40%)	Gaps:	146/613 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 GDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMV--------------KVAEWN 473
            |..:||:|......||:|.||....         .:..:.|:..:              ::..|.
Mouse   430 GQYLSRFLANTTFRGLSGSIKVKGS---------TIVSSENNFFIWNLQYDPMGKPMWTRLGSWQ 485

  Fly   474 D-----DAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQV----------------- 516
            .     |:|:.|..|:  |.:.|..........|.|::|.|::..::|
Mouse   486 GGRIVMDSGIWPEQAQ--RHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMT 548

  Fly   517 -------AFGEKLHGNN-----RFE----GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAH 565
                   :....||.:|     :|:    |||.||.:.||:::..:::|.:|.||.||:.|   :
Mouse   549 NDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWK---N 610

  Fly   566 GGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLS 630
            |.|.|:||:|:...|::|:.:.:|...|.:||||:.||.|..:.|:::......| :.:||.||.
Mouse   611 GHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLH 674

  Fly   631 QEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPL 695
            ..:|:.:   ::.:.|...|::.:   ||:                        .|.|:
Mouse   675 WTMWLGI---FVALHITAIFLTLY---EWK------------------------SPFGM------ 703

  Fly   696 PAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR 760
                   ||..:......:..:||                  :|..:..|...|.::     .|:
Mouse   704 -------TPKGRNRNKVFSFSSAL------------------NVCYALLFGRTAAIK-----PPK 738

  Fly   761 SVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQ---YGTLLHGSTW 822
            ..:||.....|..|.:..:|:|||||||.:..|::...::...|..:....|   :||:...|..
Mouse   739 CWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAE 803

  Fly   823 DFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY-ALLVESPKNEY-VNAREPCDT 885
            |:.|:|...:|    |||   :...||...:|::.::|...|. |.:::....:| |:....|..
Mouse   804 DYVRQSFPEMH----EYM---RRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861

  Fly   886 MKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSE 950
            :.||:....:|:||..|..|.|...|:..:...|.:|.:..|.:| ||:...|.......|...:
Mouse   862 LTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDK-WYKVVPCGKRSFAVTETLQ 925

  Fly   951 LSLSNVAGIFYILIGGLLVSVFVAILEY 978
            :.:.:.:|:|.:|..|..:|:...|.|:
Mouse   926 MGIKHFSGLFVLLCIGFGLSILTTIGEH 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	12/73 (16%)
		ANF_receptor	55..461	CDD:279440	9/37 (24%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	110/478 (23%)
		Lig_chan	632..967	CDD:278489	69/339 (20%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	13/75 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	108/473 (23%)
		Lig_chan	676..942	CDD:278489	69/339 (20%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		1/3 (33%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740