DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and glr-1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	977	Identity:	346/977 - (35%)
Similarity:	509/977 - (52%)	Gaps:	170/977 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 HNLNVSSRRFELQAYV-DVINTAD--AFKLS-----------------RLICNQFSRGVYSMLGA 110
            :|..||....:...|. |.||:.|  .|||:                 ..:|::...|..::|.:
Worm    37 NNEEVSRVALKAMEYTSDHINSRDDVPFKLAFDHRVVEEGAAVSWNMVNAVCDELKEGAMALLSS 101

  Fly   111 VSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSS---------GFLDFALSMRPDYHQAIIDTIQ 166
            |.....:.:...|:..:||.|:       ||..|         |.| |.:|:||...:.:.|.|.
Worm   102 VDGKGREGIRGVSDALEMPLVS-------LTALSNDDHQQQQFGNL-FEVSVRPPISELLADFIV 158

  Fly   167 FYGWRKIIYLYDSHDGLLRLQQIYQGLRP-GNESFQVELVKRISNVSMAIEFLHTLEQIGRFENK 230
            ..||.:::.|.|.....|.|..:::.||. .|.|.:..:....::......:|.....:...|..
Worm   159 HKGWGEVLVLIDPVHASLHLPSLWRHLRTRTNTSVKASMFDLPADEKQFEAYLMQFNMMRNNETN 223

  Fly   231 HIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDD--RWESEIIEFGAINITGFRIVDTN 293
            .|::||.:....:.|:.::|..:..:..|||:|:..   |  .::.|:.:.|.|||:||.|::.:
Worm   224 RILIDCASPKRLKKLLINIRSAQFNQANYHYVLANY---DFLPYDQEMFQNGNINISGFNIINKD 285

  Fly   294 RRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQ 358
            .   ||::...|.|....|:|.| :.:|.:||:.:||:.|....|.|.|:.....|....:.|.
Worm   286 G---REYWSLKKHLKTSSSLGGG-DDVSVEAAVGHDAMLVTWHGFAKCLQANDSLFHGTFRHRR- 345

  Fly   359 TLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAG--SDSGGSGGMASRALDCNTAKGWVNAWE 421
                          .:|              .||.|  .|........:|..         :::|
Worm   346 --------------FFN--------------RGFPGIYCDPLSDRSHPNRPF---------SSFE 373

  Fly   422 HGDKISRYLRKVEI---EG-LTGDIKFNDDGRRVNYTLHVVEMTVNSAMV----KVAEWNDDAGL 478
            ||..|....|.::|   || |||:|:|:..|.|.|:.:.:|::..|:...    :|..|....|.
Worm   374 HGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAWRQGVGF 438

  Fly   479 QPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLK----QVAFGEKLHGNNRFEGYCKDLADLL 539
            ..........|......|:...||.|.|..|::|:|    ::|...:..|||:|||:|.||..||
Worm   439 FSNRTVAQHSRKSQNDHKDNQVIVLTNLVAPFVMIKRECLEMANLTECQGNNKFEGFCIDLLKLL 503

  Fly   540 AKEL-GINYELRL-VKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKP 602
            |.:: ..|||::| .|.|:     ..|.|.||||:|||:...|...:|::||..|||||:|||||
Worm   504 ADKIEEFNYEIKLGTKAGS-----KQADGSWDGMIGELLSGRAHAVVASLTINQERERVVDFSKP 563

  Fly   603 FMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQ 667
            ||:.|||||||||.||...|||||.|||.|||:.:||:|||||:|:|.||||||:|||:
Worm   564 FMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFLVSRFSPYEWRV------ 622

  Fly   668 QSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSA 732
                                                  .:|:.|...:.
Worm   623 --------------------------------------EETSRGGFTIS---------------- 633

  Fly   733 VVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVT 797
              |:|||:|..||:||||||||.|:.|||:|||||:::|:|||:|::||||||||||||:|:|..
Worm   634 --NDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQA 696

  Fly   798 PINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSR-KHVFVPTYDEGIKRVRNS 861
            ||.|.||||.|::::||....|||..||:.|.:.::.:||.||.|: ..|||.:|.|||:|||:.
Worm   697 PIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERVRSH 761

  Fly   862 KGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIK 926
            ||:||.|:|:..|||.|.|:||||||||.||::.|:|||||.||..||.||||:|.|:|.|||.|
Worm   762 KGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDWKDHINLAILALQERGELKK 826

  Fly   927 LRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSR-DSRSASS 990
            |.|||||::.:|......:.|.:.|:||.||||||||:||:::|:..|:.|:.:||| ::|.::|
Worm   827 LENKWWYDRGQCDAGITVDGSSASLNLSKVAGIFYILMGGMVISMLAALGEFLYRSRIEARKSNS 891

  Fly   991 GS 992
            .|
Worm   892 NS 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	104/453 (23%)
		ANF_receptor	55..461	CDD:279440	101/432 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	215/447 (48%)
		Lig_chan	632..967	CDD:278489	159/335 (47%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	105/454 (23%)
		ANF_receptor	44..417	CDD:279440	98/425 (23%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	212/441 (48%)
		Lig_chan	593..867	CDD:278489	159/335 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167306
Domainoid	1	1.000	341	1.000	Domainoid score	I575
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	556	1.000	Inparanoid score	I600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm4754
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770