DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and glr-4

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_001254126.1 Gene:glr-4 / 174258 WormBaseID:WBGene00001615 Length:951 Species:Caenorhabditis elegans


Alignment Length:1189 Identity:311/1189 - (26%)
Similarity:498/1189 - (41%) Gaps:322/1189 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 AQPSLTEKIPLGAIFEQGTDEVQSAFKYAM--------------------LNHNLNVSSRRFEL- 77
            |..:..::..:|.|..:|:...:. .:||:                    :.::.|...|..|: 
 Worm    21 ANSAADDRFHIGTIANRGSFAYEH-LRYAIDRWNTEHGAHTQIKFSIVSPIRYDNNYEERMCEIM 84

  Fly    78 -QAYVDVI-NTADAFKLSRLI---CNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPE 137
             |..|.|: :..::.:.|:||   |:.|:....|:......||..           .|||     
 Worm    85 QQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQSTSLRDSVS-----------DFVT----- 133

  Fly   138 KVLTPSSG--------FLDFALSMRPDYHQAIIDTIQFYGWRKIIYLY----DSHDGLLRLQQIY 190
             :|.||.|        |||   |||               |...:..|    |..| |..|.|..
 Worm   134 -LLGPSRGAGARATSEFLD---SMR---------------WTGFLLAYQHGSDLED-LSPLMQYK 178

  Fly   191 QGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLG 255
            |.:..|.....:::.:..:|......||..::.  |.:..:|::..........|:|..|.|.:.
 Worm   179 QIVDTGGRRIHIKIRRLPNNTDDYEPFLKYVKT--RLKQTNIIIHSNNITVLYNLLQQARGLNMA 241

  Fly   256 RRTYHYLLSGLVMDDRWESEIIE------FGA---INITGFRIVDTNRRLVREFYDSWKRLDPQM 311
            ...:.|:.:..      :..::|      :||   .||||.::|               :.||.|
 Worm   242 EPPFSYVFTNT------DLSLLEDFLNNMYGASFHCNITGLQLV---------------KNDPMM 285

  Fly   312 SVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNY 376
                     ..|.||..:||:|:..:.                .|.:.|..|...:|...|.:  
 Worm   286 ---------KTQLALTSEAVYVVGMSI----------------YRMRELGHAPRQSSIMCDSH-- 323

  Fly   377 SASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEG-LTG 440
                                                     :.|..|..::..:||:::.. |||
 Worm   324 -----------------------------------------DIWSDGRIMNEGIRKLKLRNQLTG 347

  Fly   441 DIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVR-----LRPHVEFEKNRTY 500
            |::|..:|.|.:...|.|. .:||..||:..|::..|.. .:::|..     :.|..|..:....
 Worm   348 DVQFKSNGERDDIMYHGVG-RINSQFVKLGNWSEKRGWN-FDSRYANRWEFDIDPDSEDLEGLHL 410

  Fly   501 IVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAH 565
            .|...||||:::..         |.|::||:|.||.:.:.:.|..||.:..|:||.||.|..|  
 Worm   411 RVVVYLEEPFVIKT---------GENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDES-- 464

  Fly   566 GGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTP--GVFSFMNP 628
            |.|:|::|.|.|.|||::::|:|||..|..|:||:.|||.|||||::.:..::|.  .:::|:.|
 Worm   465 GRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLWTFLEP 529

  Fly   629 LSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGA 693
            ||..:|:|::.||..||..:..:::|||:||..:::..::.        .|.:.||:        
 Worm   530 LSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERD--------FENIKNQK-------- 578

  Fly   694 PLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLS 758
                                                     |:|:|.|||||::.:.||||.|:.
 Worm   579 -----------------------------------------NQFTVLNSFWFTMGSLMQQGSDVI 602

  Fly   759 PRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWD 823
            ||:.:.|:.|..|:.||.|:||||||.||||||||||.|||.|.:|||.|.:::||.|..|||.|
 Worm   603 PRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMD 667

  Fly   824 FFRRSQIGLHNKMWEYM-NSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMK 887
            |||.|:|.::.:||..| :|...|||.:..|||.||::  |.||.::||...||...|: |:...
 Worm   668 FFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKS--GGYAYMMESSMLEYYLERD-CELQS 729

  Fly   888 VGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAE---CSTHKDGETSHS 949
            :|..||:||:|||.|.||.|:|.::..||.|:|...|..|:||||.::.|   |......:.::|
 Worm   730 IGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEKATNS 794

  Fly   950 ELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANG 1014
            :  ..|:.||||:|:.||:|:..:|..|||..||.       ....|.:.:.|.......|.:| 
 Worm   795 K--PQNIFGIFYVLLTGLIVAFLLACGEYCIESRH-------EAFRLKLTIVGKFMDWYRGNSN- 849

  Fly  1015 SMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPAQLSAT 1079
                           .|.|||.|.:.....|...:..|..:|               ||     |
 Worm   850 ---------------DSKQRSKLRNMQLDTAGQEVSISTRHD---------------PP-----T 879

  Fly  1080 PPDAGDSLHMNAHGQVXHEHAQESRLXRTPCAPTIRRIMAN-----SRQETEKMMGGGHGGTVTV 1139
            ||.           .. ......:|| .:..||||..:..:     ||.....:...|. ..::.
 Worm   880 PPQ-----------PALTSRPDPTRLSISSPAPTICVVSCDDGTPISRDRPPSISRAGL-RRLSR 932

  Fly  1140 SVPATCSSSMNGSHEGSLA 1158
            .:||.....::...:||::
 Worm   933 MLPAATHEQLSRFRQGSMS 951

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 91/482 (19%)
ANF_receptor 55..461 CDD:279440 83/453 (18%)
PBP2_iGluR_AMPA 497..938 CDD:270433 168/446 (38%)
Lig_chan 632..967 CDD:278489 124/338 (37%)
glr-4NP_001254126.1 PBP1_iGluR_Kainate 30..385 CDD:107377 92/483 (19%)
ANF_receptor 45..365 CDD:279440 82/446 (18%)
Periplasmic_Binding_Protein_Type_2 410..775 CDD:304360 166/435 (38%)
Lig_chan 533..810 CDD:278489 124/338 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60082
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100167
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.920

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