Protein Alignment GluRIB and glr-3

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 952
• Identity: 260/952 - (27%)
• Similarity: 419/952 - (44%)
• Gaps: 246/952 - (25%)

  Fly    88 DAFKLSRLICNQFSRGVYS-----MLGA---VSPDSFD-------TLHSYSNTFQMPFVTPWFPE 137
            ::||:..:   ....|::|     :|||   :.|:.:|       .:.|.::...:|.|:
 Worm    59 ESFKIVGI---SIENGLFSVCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVS----- 115

  Fly   138 KVLTPSSGFLDFALSMRPDYH---------QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGL 193
                     |..:...||..|         .|:...|:...|:.::.:::..|.||.:..:....
 Worm   116 ---------LHLSPPTRPSTHLHPHLNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAG 171

  Fly   194 RPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT 258
            ....:||..:||:.........|..|...::.|:   .||::.|.:.|...| :...::.:....
 Worm   172 HFDPDSFSSQLVRLKHGDDYGNELKHIKNKLDRY---RIVINIPLQKALHFL-EQAANMSMCGVL 232

  Fly   259 YHYLLSGLVMD-DRWESEIIEFGAI---NITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRES 319
            |||    :||| |....:|.....|   |||.|.:.|.|...:.   |..:.:..:.|:...::.
 Worm   233 YHY----VVMDMDLVTVDIDSIRGIEDCNITSFGVHDVNSEYIE---DIRQEIVHKSSIRLPKKG 290

  Fly   320 ISAQAALMYDAVFVLVEAFNKI-LRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGG 383
            :....::..|.:.:|:.:...| :..:|
 Worm   291 VPYTTSIWIDTLRLLIRSMKSIQIWDEP------------------------------------- 318

  Fly   384 GNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDG 448
                                     .|.      ::|:.|..|.:...:..:.|::||:.:...|
 Worm   319 -------------------------RCG------SSWKSGSDIKKRFFENPLAGISGDLHWAPSG 352

  Fly   449 RRVNYTLHVVEMTVNSAMVKVAEWN---------------DDAGLQPLNAKYVRLRPHVEFEKNR 498
            .|.||||||...|:  :..|.|||:               :.:....|..|:::
 Worm   353 ERSNYTLHVYRRTL--SFQKFAEWSSRTRRIASSEAVVIANSSEKLTLEGKHLK----------- 404

  Fly   499 TYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSS 563
               ::..||.|::|:.         .|..:||||.||...:|..|...|.::.|:|..|||::|
 Worm   405 ---ISVYLEAPFVMIT---------SNGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGSKES- 456

  Fly   564 AHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNP 628
             :|.|.||||||.|.:||:|:|::||:..|..||||:.|:|.|||||:.|||..:....|.||:|
 Worm   457 -NGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDP 520

  Fly   629 LSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGA 693
            ||.::|:....||..||:.::.:::.||:|        |..:..|
 Worm   521 LSTQVWIMTFASYFVVSVAIWIIAKISPYE--------QFERDED-------------------- 557

  Fly   694 PLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLS 758
                                             .|....|.|:||:.|||||::.:.||||.:|.
 Worm   558 ---------------------------------NGQYKPVDNQFSLRNSFWFTVCSLMQQGSELC 589

  Fly   759 PRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWD 823
            ||:.|.|:....|:||.|||||||||||||.||..||.|||.:.:|||.||:::||||..|||..
 Worm   590 PRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTMS 654

  Fly   824 FFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKV 888
            ||..|:|..:.:||:.|:|...:||.:..|||.||::|  .||.|:||...||...|: |:.|::
 Worm   655 FFNESKIETYERMWQLMSSSPGLFVQSSKEGIARVKSS--DYAYLMESSMLEYAVERD-CELMQI 716

  Fly   889 GRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKA-ECSTHK-----DGETS 947
            |..:|.||:||..|.||..::.|:.|:|.|:|..||.:|:.|||.:|: .|...|     |||
 Worm   717 GGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDKSVVCEQPKRKDQDDGE-- 779

  Fly   948 HSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSAS 989
                   ::.|||.||:.||:::..:.|.|.....:.|.:.|
 Worm   780 -------SIGGIFIILVVGLVLTAVLVIFELITTRKPSPAQS 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	75/435 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	167/441 (38%)
		Lig_chan	630..966	CDD:459656	122/341 (36%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	75/423 (18%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:473866	166/448 (37%)