DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and glr-3

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	952	Identity:	260/952 - (27%)
Similarity:	419/952 - (44%)	Gaps:	246/952 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DAFKLSRLICNQFSRGVYS-----MLGA---VSPDSFD-------TLHSYSNTFQMPFVTPWFPE 137
            ::||:..:   ....|::|     :|||   :.|:.:|       .:.|.::...:|.|:
Worm    59 ESFKIVGI---SIENGLFSVCNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVS----- 115

  Fly   138 KVLTPSSGFLDFALSMRPDYH---------QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGL 193
                     |..:...||..|         .|:...|:...|:.::.:::..|.||.:..:....
Worm   116 ---------LHLSPPTRPSTHLHPHLNAKSLAVAAFIKREKWKDVVVVFEEPDELLEITDMITAG 171

  Fly   194 RPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT 258
            ....:||..:||:.........|..|...::.|:   .||::.|.:.|...| :...::.:....
Worm   172 HFDPDSFSSQLVRLKHGDDYGNELKHIKNKLDRY---RIVINIPLQKALHFL-EQAANMSMCGVL 232

  Fly   259 YHYLLSGLVMD-DRWESEIIEFGAI---NITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRES 319
            |||    :||| |....:|.....|   |||.|.:.|.|...:.   |..:.:..:.|:...::.
Worm   233 YHY----VVMDMDLVTVDIDSIRGIEDCNITSFGVHDVNSEYIE---DIRQEIVHKSSIRLPKKG 290

  Fly   320 ISAQAALMYDAVFVLVEAFNKI-LRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGG 383
            :....::..|.:.:|:.:...| :..:|
Worm   291 VPYTTSIWIDTLRLLIRSMKSIQIWDEP------------------------------------- 318

  Fly   384 GNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDG 448
                                     .|.      ::|:.|..|.:...:..:.|::||:.:...|
Worm   319 -------------------------RCG------SSWKSGSDIKKRFFENPLAGISGDLHWAPSG 352

  Fly   449 RRVNYTLHVVEMTVNSAMVKVAEWN---------------DDAGLQPLNAKYVRLRPHVEFEKNR 498
            .|.||||||...|:  :..|.|||:               :.:....|..|:::
Worm   353 ERSNYTLHVYRRTL--SFQKFAEWSSRTRRIASSEAVVIANSSEKLTLEGKHLK----------- 404

  Fly   499 TYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSS 563
               ::..||.|::|:.         .|..:||||.||...:|..|...|.::.|:|..|||::|
Worm   405 ---ISVYLEAPFVMIT---------SNGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGSKES- 456

  Fly   564 AHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNP 628
             :|.|.||||||.|.:||:|:|::||:..|..||||:.|:|.|||||:.|||..:....|.||:|
Worm   457 -NGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMHLGISILFKKPRIRDSDWFKFMDP 520

  Fly   629 LSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGA 693
            ||.::|:....||..||:.::.:::.||:|        |..:..|
Worm   521 LSTQVWIMTFASYFVVSVAIWIIAKISPYE--------QFERDED-------------------- 557

  Fly   694 PLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLS 758
                                             .|....|.|:||:.|||||::.:.||||.:|.
Worm   558 ---------------------------------NGQYKPVDNQFSLRNSFWFTVCSLMQQGSELC 589

  Fly   759 PRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWD 823
            ||:.|.|:....|:||.|||||||||||||.||..||.|||.:.:|||.||:::||||..|||..
Worm   590 PRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTMS 654

  Fly   824 FFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKV 888
            ||..|:|..:.:||:.|:|...:||.:..|||.||::|  .||.|:||...||...|: |:.|::
Worm   655 FFNESKIETYERMWQLMSSSPGLFVQSSKEGIARVKSS--DYAYLMESSMLEYAVERD-CELMQI 716

  Fly   889 GRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKA-ECSTHK-----DGETS 947
            |..:|.||:||..|.||..::.|:.|:|.|:|..||.:|:.|||.:|: .|...|     |||
Worm   717 GGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDKSVVCEQPKRKDQDDGE-- 779

  Fly   948 HSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSAS 989
                   ::.|||.||:.||:::..:.|.|.....:.|.:.|
Worm   780 -------SIGGIFIILVVGLVLTAVLVIFELITTRKPSPAQS 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	75/433 (17%)
		ANF_receptor	55..461	CDD:279440	70/401 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	167/441 (38%)
		Lig_chan	632..967	CDD:278489	121/340 (36%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	75/423 (18%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	166/448 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810