DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grin3b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	199/1016 - (19%)
Similarity:	350/1016 - (34%)	Gaps:	325/1016 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFD-------TLHS 121
            |.|||::     ||.|...  .|.|...|:|.:|.     |.:..|.|:..:|.       .|..
  Rat    66 LPHNLSL-----ELVAVAS--PTRDPASLARGLCQ-----VLAPPGVVASIAFPEARPELRLLQF 118

  Fly   122 YSNTFQMPFVTPWFPEKVL-----------TPSSGFLDFALSMRPDYHQAIIDT----IQFYGWR 171
            .:...:.|.|:      ||           ||....||:|..:     :.|:|.    ::.:.|.
  Rat   119 LAAATETPVVS------VLRREVRTALGAPTPFHLQLDWASPL-----ETILDVLVSLVRAHAWE 172

  Fly   172 KI-------------IYLYDSHDG--------LLRLQQIYQGLRPGNESFQVELVKRISNVSMAI 215
            .|             :.|:.:|..        |.||......||.|                  :
  Rat   173 DIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAG------------------L 219

  Fly   216 EFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRW------ES 274
            ..|..||..|......::|.|.|..|                  |.:|.......:|      .:
  Rat   220 ALLGALEGGGTPVPAAVLLGCSTARA------------------HEVLEAAPPGPQWLLGTPLPA 266

  Fly   275 EIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFN 339
            |     |:..||.                     |...:..|.....:..|:::|.|.::.:|.:
  Rat   267 E-----ALPTTGL---------------------PPGVLALGETEQHSLEAVVHDMVELVAQALS 305

  Fly   340 KILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMA 404
            .:....|::              |...|..:.|...                     :|||...
  Rat   306 SMALVHPER--------------ALLPAVVNCDDLK---------------------TGGSEAT- 334

  Fly   405 SRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVN------ 463
                              |..::|:|.....:|.||.: :.....:|:.:.|....::.
  Rat   335 ------------------GRTLARFLGNTSFQGRTGAV-WVTGSSQVHVSRHFKVWSLRRDPLGA 380

  Fly   464 SAMVKVAEWNDD--------AGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLK------ 514
            .|...|..|.|.        |.|:..:....:.||.:.        |.|::|.|::..:
  Rat   381 PAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLR--------VVTLVEHPFVFTRESDEDG 437

  Fly   515 -----QVAFGEKLHGNNRFE--------------------GYCKDLADLLAKELGINYELRLVKD 554
                 |:......:.:.|.:                    |||.||.:.||::|..::||.:|.|
  Rat   438 QCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGD 502

  Fly   555 GNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQT 619
            |.||:.:.   |.|.|:||:|:...|.:|:.:.:|.:.|.:|:||:.||.|..:.||::.....:
  Rat   503 GKYGALRD---GRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTAS 564

  Fly   620 PGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQ 684
            | :.:||.||...:||.|   :..:.:...|::.:   |||
  Rat   565 P-IGAFMWPLHWSMWVGV---FAALHLTALFLTLY---EWR------------------------ 598

  Fly   685 QPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAA 749
            .|.|:             ||                     .|.:...|.:..|..|..:..|
  Rat   599 SPYGL-------------TP---------------------RGRNRGTVFSYSSALNLCYAIL-- 627

  Fly   750 FMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQ-- 812
            |.:.....:|:..:||.....|..|.|:::|||||||||.:..::....::...|..:....|
  Rat   628 FGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGF 692

  Fly   813 -YGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY-ALLVESPKNE 875
             :||:...|...:.:.|...:|..|      |:| ..||...|:..:.:...|. |.:::....:
  Rat   693 RFGTVWESSAEAYIKASFPEMHAHM------RRH-SAPTTPHGVAMLTSDPPKLNAFIMDKSLLD 750

  Fly   876 Y-VNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECS 939
            | |:....|..:.||:....:|:||..|..|.|...::..:...|.:|.:..|.:| ||:...|.
  Rat   751 YEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK-WYKMVPCG 814

  Fly   940 THKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980
            ......|...::.:.:.:|:|.:|..||..::..::.|:.|
  Rat   815 KRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVF 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	79/476 (17%)
		ANF_receptor	55..461	CDD:279440	74/445 (17%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	108/476 (23%)
		Lig_chan	632..967	CDD:278489	69/339 (20%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	80/478 (17%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	108/479 (23%)
		Lig_chan	576..842	CDD:278489	69/339 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349648
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840