DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria2b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	1058	Identity:	416/1058 - (39%)
Similarity:	569/1058 - (53%)	Gaps:	232/1058 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLS 93
            |:.....||    :.:|.:|.:|.|:..|||:..|    :...:..|.|..::|.:..|::|.::
Zfish    17 GMTTGGSPS----VQIGGLFPRGADQEYSAFRIGM----VQFGTAEFRLTPHIDNLEVANSFAVT 73

  Fly    94 RLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPDYH 158
            ...|:|||||||::.|.....|.:|:.|:..|..:.|:||.|      |..|...|.:.||||..
Zfish    74 NCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PLDGNQQFIIQMRPDIK 132

  Fly   159 QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNV--SMAIEFLHTL 221
            ..::..|::|.|.|..|||||..||..||.:..  ....:.:||..: .:.|:  ....|...:|
Zfish   133 GPLLSLIEYYKWDKFAYLYDSDRGLTTLQVVLD--TAAEKKWQVTAI-NVGNMKDERKDEAYRSL 194

  Fly   222 EQIGRFENK---HIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDDRWESEIIEFGA 281
            .|  ..|||   .::|||..:..|.|:.|.:   .:||  :.|||:::.|...|...|: |::|.
Zfish   195 FQ--DLENKKERRVILDCEQDKVKDIMEQVI---TIGRHVKGYHYIIANLGFVDGDLSK-IQYGG 253

  Fly   282 INITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKP 346
            .|::||:|||.:..||.:|...|:.|:.:...||. ..|...:||.||||.|:.|||..:.:::.
Zfish   254 ANVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGAD-SKIRYTSALTYDAVQVMTEAFRYLHKQRI 317

  Fly   347 DQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC- 410
            |     :.||:                           |.|                     ||
Zfish   318 D-----ISRRA---------------------------NNG---------------------DCL 329

  Fly   411 -NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEW-- 472
             |.|.    .|..|.:|.|.|::|.::||||:|:|:..|:|||||::|:|:..|.| ||:..|
Zfish   330 ANPAV----PWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVNVMELKSNGA-VKIGYWNE 389

  Fly   473 -------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHG 524
                         ||..||:                 |:|.||||:||.||:|||:.|  :....
Zfish   390 VDKMVVTKSDLFPNDTMGLE-----------------NKTVIVTTILEAPYVMLKKNA--DLFMD 435

  Fly   525 NNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTI 589
            |.|:||||.|||..:||..|..|:|::|.||.||:..:... .|:|||||||..:||||:|.:||
Zfish   436 NERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETK-IWNGMVGELVYGKADIAVAPLTI 499

  Fly   590 TAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRF 654
            |..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|||||:|||.||||
Zfish   500 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 564

  Fly   655 SPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAAL 719
            ||:||...:.:..|.|:.:.
Zfish   565 SPYEWHTEEYEDGQIQTNES--------------------------------------------- 584

  Fly   720 SAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTA 784
                          .|||.::||.||||.|||:||||:||||:||||....|:|||||:||||||
Zfish   585 --------------TNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 635

  Fly   785 NLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYM-NSRKHVFV 848
            ||||||||||||:||.|.||||.|||:.||||..|||.:|||||:|.|.:|||.|| .:...|||
Zfish   636 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAEPSVFV 700

  Fly   849 PTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINL 913
            .|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:|||||.||:|::.:||
Zfish   701 KTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNL 765

  Fly   914 AVLTLKENGELIKLRNKWWYEKAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILE 977
            |||.|.|.|.|.||:|||||:|.|| |...|.:...|.||||||||:||||:|||.:::.||::|
Zfish   766 AVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALVE 830

  Fly   978 YCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMH 1042
            :|::||                                            ..:...:.|.:|.|.
Zfish   831 FCYKSR--------------------------------------------AEAKRMKVTFSDAMR 851

  Fly  1043 AKAKLTIQASRDYDNGRV 1060
            :||:|::..|.. :||||
Zfish   852 SKARLSVTGSTG-ENGRV 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	135/458 (29%)
		ANF_receptor	55..461	CDD:279440	124/414 (30%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	239/441 (54%)
		Lig_chan	632..967	CDD:278489	177/336 (53%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	133/445 (30%)
		ANF_receptor	55..377	CDD:279440	120/394 (30%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	239/441 (54%)
		Lig_chan	542..820	CDD:278489	177/336 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590941
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770