DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria2a

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	1072	Identity:	435/1072 - (40%)
Similarity:	584/1072 - (54%)	Gaps:	227/1072 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GLKLSCLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNL 68
            ||.|..||                 |:.:...||    :.:|.:|.:|.|:..|||:..|    :
Zfish     5 GLLLPALW-----------------GLALGGSPS----VQIGGLFPRGADQEYSAFRIGM----V 44

  Fly    69 NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 133
            ...:..|.|..::|.:..|::|.::...|:|||||||::.|.....|.:|:.|:..|..:.|:||
Zfish    45 QFGTAEFRLTPHIDNLEVANSFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITP 109

  Fly   134 WFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNE 198
            .|      |:.|...|.|.||||....:|..:::|.|.|..|||||..||..||.:..  .....
Zfish   110 SF------PADGLNQFVLQMRPDIKGPLISLVEYYKWEKFAYLYDSDRGLSTLQAVLD--TAAER 166

  Fly   199 SFQVELVKRISNV--SMAIEFLHTLEQIGRFENKH---IVLDCPTEMAKQILIQHVRDLRLGR-- 256
            .:||..: .:.|:  ....|...:|.|  ..|||:   ::|||..:..|.|:.|.:   .:||
Zfish   167 KWQVTAI-NVGNLKDEWKDEAYRSLFQ--DLENKNERRVILDCEQDKVKDIMEQVI---TIGRHV 225

  Fly   257 RTYHYLLS--GLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRES 319
            :.|||:::  |.|..|..:   |::|..|::||:|||.:..||.:|...|:.|:.:...||. ..
Zfish   226 KGYHYIIANFGFVDGDLSK---IQYGGANVSGFQIVDFDDPLVAKFDQRWEALEEKEYPGAD-SR 286

  Fly   320 ISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGG 384
            |...:||.||||.|:.||| :.|.|:    |.::.||                           |
Zfish   287 IRYTSALTYDAVQVMTEAF-RFLHKQ----RIDISRR---------------------------G 319

  Fly   385 NGGAGGGFAGSDSGGSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDD 447
            |.|                     ||  |.|.    .|..|.:|.|.|::|.::||||:|:|:..
Zfish   320 NNG---------------------DCLANPAV----PWAQGVEIERALKQVRVDGLTGNIQFDQY 359

  Fly   448 GRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEF-EKNRTYIVTTVLEEPYI 511
            |||||||::|:|:. ||..||:..||:   :..:......|.|:... .:|:|.||||:||.||:
Zfish   360 GRRVNYTVNVMELK-NSGPVKIGYWNE---MDKMAVTKSDLFPNDTMGMENKTVIVTTILEAPYV 420

  Fly   512 MLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
            |||:.|  |....|.|:||||.|||..:||..|..|:||:|.||.||:..:... .|:|||||||
Zfish   421 MLKKNA--ELFTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETK-IWNGMVGELV 482

  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSY 641
            ..:||||:|.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|
Zfish   483 YGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAY 547

  Fly   642 IGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGA 706
            ||||:|||.||||||:||                 |.|:..:.|             .||
Zfish   548 IGVSVVLFLVSRFSPYEW-----------------HTEEFEDGQ-------------LGP----- 577

  Fly   707 QTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASW 771
                                    |...|||.::||.||||.||||||||:||||:||||....|
Zfish   578 ------------------------SESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 618

  Fly   772 FFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKM 836
            :|||||:||||||||||||||||||:||.|.||||.|||:.||||..|||.:|||||:|.|.:||
Zfish   619 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKM 683

  Fly   837 WEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900
            |:||.|.: .|||....||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:|||
Zfish   684 WQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIA 748

  Fly   901 TPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSH--SELSLSNVAGIFYIL 963
            ||.||||::.:|||||.|.|.|.|.||:|||||:|.||.: ..||:..  |.||||||||:||||
Zfish   749 TPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGS-GGGESKEKTSALSLSNVAGVFYIL 812

  Fly   964 IGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGM 1028
            :|||.:::.||::|:|::||                                            .
Zfish   813 VGGLGLAMLVALVEFCYKSR--------------------------------------------A 833

  Fly  1029 PSSHQRSTLTDTMHAKAKLTIQASRDYDNGRV 1060
            .:...:.|.||.|.:||:|:|..|.. :||||
Zfish   834 EAKRMKMTFTDAMRSKARLSITGSTG-ENGRV 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	139/445 (31%)
		ANF_receptor	55..461	CDD:279440	129/416 (31%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	247/441 (56%)
		Lig_chan	632..967	CDD:278489	183/337 (54%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	139/450 (31%)
		ANF_receptor	51..373	CDD:279440	125/396 (32%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	246/438 (56%)
		Lig_chan	538..816	CDD:278489	183/337 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590940
Domainoid	1	1.000	371	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	698	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm6377
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770