DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grin2c

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	1234	Identity:	274/1234 - (22%)
Similarity:	448/1234 - (36%)	Gaps:	347/1234 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIF-EQGTDEVQSAFKYAMLNHNLNVSSR 73
            |.|:.||.....:..|.|:|.|..|       :.:..:| ..|..:.|:..:....|. |::.
Mouse    67 LGPALLLTSLLGAWAGLGAGQGEQA-------VTVAVVFGSSGPLQAQARTRLTPQNF-LDLP-- 121

  Fly    74 RFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDT------LHSYSNTFQMPFVT 132
             .|:|.....:|..:...:...||...  |...:.|.|..|:.||      |...|:...:|.::
Mouse   122 -LEIQPLTIGVNNTNPSSILTQICGLL--GAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILS 183

  Fly   133 -PWFPEKVLT---PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGL 193
             ......|||   |.|.||...:|:.... |.:...::.|.|...              .:...|
Mouse   184 ISGGSAVVLTPKEPGSAFLQLGVSLEQQL-QVLFKVLEEYDWSAF--------------AVITSL 233

  Fly   194 RPGNESFQVELVKRISNVS-MAIEFLHTLE-QIG----RFENKHIV--LDCPTEMAKQILIQHVR 250
            .||:..| :|.|:.:::.| ::...|..|. ::|    |...:.::  :|.|      :|:.:.
Mouse   234 HPGHALF-LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAP------VLVAYC- 290

  Fly   251 DLRLGRRTYHYLLSGLVMDDRWESEII--EFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSV 313
                               .|.|:|::  |.....:.|...|             |  |.|.:::
Mouse   291 -------------------SREEAEVLFAEAAQAGLVGPGHV-------------W--LVPNLAL 321

  Fly   314 GAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSA 378
            |:   :.:..||.....:.|:.|::...||:|                |....|..:...::|..
Mouse   322 GS---TDAPPAAFPVGLISVVTESWRLSLRQK----------------VRDGVAILALGAHSYRR 367

  Fly   379 SGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIK 443
            .                    .|.:.:.|.||.:..|.|:...  :...|:|..|..||  .|..
Mouse   368 Q--------------------YGTLPAPAGDCRSHPGPVSPAR--EAFYRHLLNVTWEG--RDFS 408

  Fly   444 FNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGL----QPLNAKY-VRLRPHVEFEKNRTYIVT 503
            |:..|..|..|:.|:.:..:.....|..|  |.|:    .|:..:| ..|:|.|:   :|...|.
Mouse   409 FSPGGYLVQPTMVVIALNRHRLWEMVGRW--DHGVLYMKYPVWPRYSTSLQPVVD---SRHLTVA 468

  Fly   504 TVLEEPYIMLKQVAFGE----------KLHGNNRF-------------EGYCKDLADLLAKELGI 545
            |:.|.|:::::....|.          :...|:.|             :|:|.|:...|||.:..
Mouse   469 TLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKF 533

  Fly   546 NYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISI 610
            :|:|.||.:|.:|..   ..|.|:||:||:..|.||:||.::||..||..:||||.||:..|||:
Mouse   534 SYDLYLVTNGKHGKR---VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISV 595

  Fly   611 MIKKPVKQTPGVFSFMNPLSQEIWVSV-IFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDP 674
            |:.:. ..|....:|:.|.|..:||.: :.....|:|.:|....|||..:
Mouse   596 MVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY--------------- 644

  Fly   675 HAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSV 739
                    ||.                                 |:.|.. |||.|      |::
Mouse   645 --------NQN---------------------------------LTKGKK-SGGPS------FTI 661

  Fly   740 WNSFWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPE 803
            ..|.|...|........: :||..:.:|....|.||.:|.::|||||||||:..|:.:..::...
Mouse   662 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLS 726

  Fly   804 DLAMQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSK 862
            |...|      ...::||:.:|||....|.:...:|..|.::........:.:...|.:.|  |:
Mouse   727 DKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGARHV--SR 789

  Fly   863 GKYALLVESPKNEYVNAR-EPCD--TMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGEL 924
            ...|.:.::....|:..: |.|.  |:..|:...|.|:|||....|..|..|:||:|....:||.
Mouse   790 KLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGET 854

  Fly   925 IKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSAS 989
            .||...|.  ...|...|: |...|:|.:.|:||:||:|:..:.:::.|...|:....:...|..
Mouse   855 QKLETVWL--SGICHNEKN-EVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVP 916

  Fly   990 SGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRD 1054
            |.|.:...:    ..|.|.....||...| ||.|.|   ||.   .....:..|.....:||:||
Mouse   917 SSSQLDFLL----AFSRGIYSCFNGVQSL-PSPARP---PSP---DLTAGSAQANVLKMLQAARD 970

  Fly  1055 --------------------YDNGR-------VGYLNCASLQYYPPAQLSAT---PPDAGDSLHM 1089
                                :.|.|       .|..:|..   .||.|.|.:   ||..|
Mouse   971 MVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSCTP---GPPGQPSPSGWRPPGGG----- 1027

  Fly  1090 NAHGQVXHEHAQESRLXRTPCA-----PTIRRIMANSRQETEKMMGGGHGGTVTVSVPATCSSS 1148
                             |||.|     |..|                          ||||:.|
Mouse  1028 -----------------RTPLARRAPQPPAR--------------------------PATCAGS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	84/455 (18%)
		ANF_receptor	55..461	CDD:279440	79/425 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	121/474 (26%)
		Lig_chan	632..967	CDD:278489	83/345 (24%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	86/470 (18%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	122/476 (26%)
		NMDAR2_C	905..>980	CDD:371139	19/85 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740