Protein Alignment GluRIB and Grik5

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 1159
• Identity: 353/1159 - (30%)
• Similarity: 520/1159 - (44%)
• Gaps: 298/1159 - (25%)

  Fly    34 AQPS--LTEKIPLGAIFEQGT-----DEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91
            |.||  :...:.:.||.:..|     :.:..|.....:|..:.|.::     |.|:|    |.|:
Mouse    14 ANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAK-----ARVEV----DIFE 69

  Fly    92 LSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFL 147
            |.|        .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  ||...:|
Mouse    70 LQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYL 131

  Fly   148 DFA-LSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVE----- 203
            .|| :|:.|   |...|:...::.:.:.....:....:.||||:::.:|.....|:..|.
Mouse   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDS 196

  Fly   204 -----LVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQI-----------LIQHVRDL 252
                 |:|.|.:..::...:.....|     .|:||.....::..:           .:....:|
Mouse   197 RDPTPLLKEIRDDKVSTIIIDANASI-----SHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASEL 256

  Fly   253 RLGRRTYHYLLS----------GLVMDDRWESEIIEFGAINITGFRIVDTNR----RLVREFYDS 303
            .:....|.|:|:          |:|.|           :.||.||.:.:|:.    ..||....|
Mouse   257 GMTSAFYKYILTTMDFPILHLDGIVED-----------SSNILGFSMFNTSHPFYPEFVRSLNMS 310

  Fly   304 WKRLDPQMSVGAGRESISA--------QAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTL 360
            |            ||:..|        .||||:|||.|:|.|..::             .|||.:
Mouse   311 W------------RENCEASTYPGPALSAALMFDAVHVVVSAVREL-------------NRSQEI 350

  Fly   361 MVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDK 425
            .|                                           :.|.|.:|    |.|.||..
Mouse   351 GV-------------------------------------------KPLACTSA----NIWPHGTS 368

  Fly   426 ISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRP 490
            :..|||.||.:||||.::||..|:|.||||.::|.: .....::..|..:..| .:||..:.:..
Mouse   369 LMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHREIGVWYSNRTL-AMNATTLDINL 431

  Fly   491 HVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDG 555
            . :...|:|.:|||:||.||:| ::..| :.|.||.||||:|.|:...||:.|...|.||||:||
Mouse   432 S-QTLANKTLVVTTILENPYVM-RRPNF-QALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDG 493

  Fly   556 NYGSEKSSAHGGWDGMVGELV-RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQT 619
            .||:.:  .:|.|.||||||: |::||:|:||.|||||||:|||||||||:|||||:.:..:.:.
Mouse   494 LYGAPE--PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRK 556

  Fly   620 PGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQ 684
            ||.|||::|.|..:|:.::.:|:.||.|||..:|.||:||    ..|.......||
Mouse   557 PGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW----YNPHPCLRARPH--------- 608

  Fly   685 QPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAA 749
                                                           .:.|::::.||.||.:..
Mouse   609 -----------------------------------------------ILENQYTLGNSLWFPVGG 626

  Fly   750 FMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYG 814
            |||||.::.||::|.|..:..|:.||||:||||||||||||||:||..|:.|.:|||.||.::||
Mouse   627 FMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYG 691

  Fly   815 TLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVN 878
            |:..|||..||:.|:...:.:||.||.|:: .|||.:.:|||.||.||  :||.|:||..||| :
Mouse   692 TIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-H 753

  Fly   879 AREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKD 943
            .|..|:..::|..|||||:||..||||..:|.|.||:|.|:||..|..|:.||| |...|...:|
Mouse   754 RRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWW-EGGRCPKEED 817

  Fly   944 GETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASS------------------ 990
            ...  ..|.:.|:.|||.:||.||:::||||::|:.:.:|  |||.|
Mouse   818 HRA--KGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTR--RSAESEEVSVCQEMLQELRHAVS 878

  Fly   991 --------------GSGMGL-------GMGLGGGM-----SGGSLGKANGSMMLGPSSAVPGGMP 1029
                          |....|       .|.|..|.     :||..|...|...|......||| |
Mouse   879 CRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGPPGG-P 942

  Fly  1030 SSHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDA 1083
            .....:..|.....:....|||.|            ||....||..| .||.:|
Mouse   943 RPQAPTPCTHVRVCQECRRIQALR------------ASGAGAPPRGL-GTPAEA 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	108/495 (22%)
		ANF_receptor	55..461	CDD:279440	104/461 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	191/442 (43%)
		Lig_chan	632..967	CDD:278489	126/335 (38%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	109/502 (22%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	190/438 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650