DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grik2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	1032	Identity:	352/1032 - (34%)
Similarity:	527/1032 - (51%)	Gaps:	196/1032 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFE------QGTDEVQSAFKYAM--LNHN---L 68
            |||:.:|.|              .|..:..|.|||      .|.:|:  ||::|:  :|.|   |
Mouse    23 LLWIGYSQG--------------TTHVLRFGGIFEYVESGPMGAEEL--AFRFAVNTINRNRTLL 71

  Fly    69 NVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 133
            ..::..::.|.    ||..|:|:.|:..|:|.|.||.::.|.....|.:.:.|..|...:|.:..
Mouse    72 PNTTLTYDTQK----INLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQT 132

  Fly   134 WFPEKVLTPSSGFLDFALSMRPDY---HQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRP 195
            .:..:|   |.....|.:|:.||:   .:||:|.:||:.|:.:..:||...||:|||
Mouse   133 RWKHQV---SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQ-------- 186

  Fly   196 GNESFQVELVKRISNVSMAIEFLH----------TLEQIGRFENKHIVLDCPTEMAKQILIQHVR 250
                   ||:|..|..::.::...          .|:::.|.:..|::.||..|||..||.|
Mouse   187 -------ELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQ--- 241

  Fly   251 DLRLGRRT--YHYLLSGLVMDDRW--ESEIIEFGAINITGFRIVDTNRRLVREFYDSW--KRLD- 308
            .|.:|..|  |||:.:.|   |.:  :.|...:..:|:|||||::|....|....:.|  :||.
Mouse   242 ALAMGMMTEYYHYIFTTL---DLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQA 303

  Fly   309 -PQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSD 372
             |:...|.....::..||||||||.|:..|               ||:..|
Mouse   304 PPKPDSGLLDGFMTTDAALMYDAVHVVSVA---------------VQQFPQ-------------- 339

  Fly   373 GYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEG 437
                                          |...:|.||..|    .|..|.:....:::...||
Mouse   340 ------------------------------MTVSSLQCNRHK----PWRFGTRFMSLIKEAHWEG 370

  Fly   438 LTGDIKFN-DDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYI 501
            |||.|.|| .:|.|.::.|.|:.:. ...:.|:..|:..:||....::..:.....:...||:.|
Mouse   371 LTGRITFNKTNGLRTDFDLDVISLK-EEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLI 434

  Fly   502 VTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHG 566
            |||:|||||::.|:  ..:.|:||:||||||.||...|:..||..||:|||:||.||:: ...:|
Mouse   435 VTTILEEPYVLFKK--SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQ-DDVNG 496

  Fly   567 GWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQ 631
            .|:|||.||:..:||:|:|.:.||..||:|||||||||:|||||:.:||....||||||:||||.
Mouse   497 QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP 561

  Fly   632 EIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQ--LANQQPPGIIGGAP 694
            :||:.::.:|:|||.|||.::|.|...|   .:.|..|     |.||.|  |..|.....: ...
Mouse   562 DIWMYILLAYLGVSCVLFVIARQSKFSW---FKYPNCS-----HYHHSQRCLCTQHLESYM-ELC 617

  Fly   695 LPAP-----PGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQG 754
            |.:|     |.|..|                        .|..|.|.|::.|||||.:.|.||||
Mouse   618 LFSPYEWYNPHPCNP------------------------DSDVVENNFTLLNSFWFGVGALMQQG 658

  Fly   755 CDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHG 819
            .:|.|:::|.||....|:|||||:|||||||||||||||||.:||:|.:|||.||:::||.:..|
Mouse   659 SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDG 723

  Fly   820 STWDFFRRSQIGLHNKMWEYMNSRKH-VFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPC 883
            :|..||::|:|..::|||.:|:||:. |.|.:.:|||:||..|  .||.|:||...|:|..|. |
Mouse   724 ATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-C 785

  Fly   884 DTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSH 948
            :..::|..:|:||:|:.||:||..:|.|.:|:|.|:|.|:|..::.|||.... |...:..|.
Mouse   786 NLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEA-- 847

  Fly   949 SELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSR-----DSRSASSGSGMGLGMGL 1000
            |.|.:.|:.|||.:|..||::|||||:.|:.::|:     :.||..|.....|.|.|
Mouse   848 SALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	118/467 (25%)
		ANF_receptor	55..461	CDD:279440	110/432 (25%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	202/448 (45%)
		Lig_chan	632..967	CDD:278489	135/342 (39%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	120/470 (26%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	201/443 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750