DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grik1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	978	Identity:	330/978 - (33%)
Similarity:	508/978 - (51%)	Gaps:	192/978 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LGAIFEQGTDE----VQSAFKYAMLNHNLN-----VSSRRFELQAYVDVINTADAFKLSRLICNQ 99
            :|.|||...:|    .:.|||:|:.:.|.|     .::..:::|.    ||..|:|:.||..|:|
Mouse    39 IGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR----INLFDSFEASRRACDQ 99

  Fly   100 FSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTPSSGFLD-FALSMRPDY---HQ 159
            .:.||.::.|.....|...:.|..|..::|.: |.|     ..||....| |.:::.|||   .:
Mouse   100 LALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW-----KHPSVDNRDLFYINLYPDYAAISR 159

  Fly   160 AIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQI 224
            |::|.:.:|.|:.:..:|:...||:|||::.:.  |...:.::::.:..|....|...|..:::.
Mouse   160 AVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKA--PSRYNIKIKIRQLPSGNKDAKPLLKEMKKG 222

  Fly   225 GRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLSGLVMDDRW--ESEIIEFGAINIT 285
            ..|   :::.||..|.|.:||.|   .|.:|..|  |||..:.|   |.:  :.|:..:..:|:|
Mouse   223 KEF---YVIFDCSHETAAEILKQ---ILFMGMMTEYYHYFFTTL---DLFALDLELYRYSGVNMT 278

  Fly   286 GFRIVDTNRRLVREFYDSW--KRLD--PQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKP 346
            |||:::.:...|....:.|  :||.  |:...|.....::.:||||||||:::..|
Mouse   279 GFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGVMTTEAALMYDAVYMVAIA--------- 334

  Fly   347 DQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCN 411
                   ..|:..|.|:                                           :|.|:
Mouse   335 -------SHRASQLTVS-------------------------------------------SLQCH 349

  Fly   412 TAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-DDGRRVNYTLHVVEM----------TVNSA 465
            ..|    .|..|.:....:::...:||||.|.|| .||.|.::.|.::.:          .|:..
Mouse   350 RHK----PWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKH 410

  Fly   466 MVKVAE----WNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNN 526
            :.||.:    ||.::||...:....|.....:...|||.||||:|||||:|.::  ..:.|:||:
Mouse   411 LYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRK--SDKPLYGND 473

  Fly   527 RFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITA 591
            ||||||.||...|:..||..|:::||.||.||::...  |.|:|||.||:...||:|:|.:|||.
Mouse   474 RFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDK--GEWNGMVKELIDHRADLAVAPLTITY 536

  Fly   592 ERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSP 656
            .||:|||||||||:|||||:.:||....||||||:||||.:||:.|:.:.:|||.|||.::||:|
Mouse   537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTP 601

  Fly   657 HEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSA 721
            :||.            :||                    |..|
Mouse   602 YEWY------------NPH--------------------PCNP---------------------- 612

  Fly   722 GSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANL 786
                   .|..|.|.|::.|||||.:.|.||||.:|.|:::|.||....|:|||||:||||||||
Mouse   613 -------DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670

  Fly   787 AAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKH-VFVPT 850
            |||||||||.:||:|.:|||.||:::||.:..|||..||::|:|..:.|||.:|:||:. ..|..
Mouse   671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKN 735

  Fly   851 YDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAV 915
            .||||:||..:  .||||:||...|||..|. |:..::|..:|:||:|:.||:||..:|.|.:|:
Mouse   736 SDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797

  Fly   916 LTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980
            |.|:|.|:|..::.|||  :......:|.:.: |.|.:.|:.|||.:|..||::||||||.|:.:
Mouse   798 LQLQEEGKLHMMKEKWW--RGNGCPEEDSKEA-SALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859

  Fly   981 RSR 983
            :||
Mouse   860 KSR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	111/470 (24%)
		ANF_receptor	55..461	CDD:279440	101/434 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	197/441 (45%)
		Lig_chan	632..967	CDD:278489	129/335 (39%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	113/474 (24%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	197/438 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650