DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grid1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	984	Identity:	262/984 - (26%)
Similarity:	430/984 - (43%)	Gaps:	193/984 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICNQFSRGVY 105
            |.:|||||:...:....|:.|:.:.:||....:.|...| :.||...:.|:..:..|:..::|:.
Mouse    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGIL 88

  Fly   106 SMLGAVSPDSFDTLHSYSNTFQMP--FV--TPWFPEKV---LTPSSGFLDFALSMRPD--YHQAI 161
            :::.:....|.:.|.|.::...:|  ||  .|....:.   |.||.....:.|:.||.  .:..:
Mouse    89 ALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVM 153

  Fly   162 IDTIQFYGWRKIIYLYDSHDGLLRLQQ-IYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIG 225
            :..:....|:|.:..|||...:..||. :.|..|.|.:....::.|.||:|..::......|::.
Mouse   154 LRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELN 218

  Fly   226 RFEN---KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIE-----FGAI 282
            |:.:   :.|:|..|  ......|....:..|..:..|::   .|.::..:.||::     .|.:
Mouse   219 RYRDTLRRAILLLSP--QGAHSFINEAVETNLASKDSHWV---FVNEEISDPEILDLVHSALGRM 278

  Fly   283 NITG--FRIVDTNRRLVREFYDSWKRL-DPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRK 344
            .:..  |.....|::.:|..:.....| |||...   .:.:......:||:|.:|..||:   ||
Mouse   279 TVVRQIFPSAKDNQKCMRNNHRISSLLCDPQEGY---LQMLQISNLYLYDSVLMLANAFH---RK 337

  Fly   345 KPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALD 409
            ..|:..::                                                  |||  |:
Mouse   338 LEDRKWHS--------------------------------------------------MAS--LN 350

  Fly   410 CNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSA----MVKVA 470
            |  .:.....|..|..:...::|..|.||||.::|.:|.........::..|.:..    |.|:|
Mouse   351 C--IRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLA 413

  Fly   471 EWNDDAGL------QPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFE 529
            .|:.:.||      :|:.::...|          |..|.||||||::|:.:...|:.    .|::
Mouse   414 TWDSEKGLNGSLQERPMGSRLQGL----------TLKVVTVLEEPFVMVAENILGQP----KRYK 464

  Fly   530 GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERE 594
            |:..|:.|.|||.||..||:....||.||.:..:.  .|:||:|||:.|.||:||:|:|||.|||
Mouse   465 GFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNT--SWNGMIGELISKRADLAISAITITPERE 527

  Fly   595 RVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEW 659
            .|:||||.:|...:.|:|||| ::...:||...|....:|..:..:...|.:::|.::|.
Mouse   528 SVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRI----- 586

  Fly   660 RLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSP 724
                 |..:|||          |.|                 |.|.|     :|.|.:|:
Mouse   587 -----QAVRSQS----------ATQ-----------------PRPSA-----SATLHSAI----- 609

  Fly   725 GSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAF 789
                               |....||:|||.:.|..||:.||...||:.||||:.||||||||||
Mouse   610 -------------------WIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAF 655

  Fly   790 LTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRR------SQIGLHNKMWEYM--NSRKHV 846
            |||.||..||.:.:||:.|.|:.|||:...:.:::||.      .|.....::|..:  |.....
Mouse   656 LTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADN 720

  Fly   847 FVPTYDEGIKRVRNSKGKYALLVESPKNEYVN-AREPCDTMKVGRNLDTKGFGIATPLGSALKDP 910
            .|....|||::.:  ||.||.|.:....||.. ..:.|....:|.::.:||:|||...||..:|.
Mouse   721 CVSNPSEGIRKAK--KGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDL 783

  Fly   911 INLAVLTLKENGELIKLRNKWWYEKAEC--STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFV 973
            .:..:|.|::.|:|..|:.|||.....|  ::|...:|....|.|.:.||:|.||..|||::..|
Mouse   784 FSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLV 848

  Fly   974 AILEYCFRS 982
            |.||..:.|
Mouse   849 AALELWWNS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	91/460 (20%)
		ANF_receptor	55..461	CDD:279440	81/427 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	148/449 (33%)
		Lig_chan	632..967	CDD:278489	101/345 (29%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		95/476 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	93/462 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	148/454 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846171
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740