DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Gria2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	1062	Identity:	426/1062 - (40%)
Similarity:	585/1062 - (55%)	Gaps:	213/1062 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQA 79
            :||         |...|||     :..|.:|.:|.:|.|:..|||:..|    :..|:..|.|..
Mouse    14 VLW---------GLIFGVS-----SNSIQIGGLFPRGADQEYSAFRVGM----VQFSTSEFRLTP 60

  Fly    80 YVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSS 144
            ::|.:..|::|.::...|:|||||||::.|.....|.:|:.|:..|..:.|:||.|      |:.
Mouse    61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PTD 119

  Fly   145 GFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK--R 207
            |...|.:.||||...|::..|::|.|.|..|||||..||..||.:...  ...:.:||..:.  .
Mouse   120 GTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDS--AAEKKWQVTAINVGN 182

  Fly   208 ISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMDD 270
            |:|......:....:.:...:.:.::|||..:....|:.|.:   .:|:  :.|||:::.|...|
Mouse   183 INNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVI---TIGKHVKGYHYIIANLGFTD 244

  Fly   271 RWESEI--IEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFV 333
               .::  |:||..|::||:|||.:..||.:|.:.|..|:.:...||...:|...:||.||||.|
Mouse   245 ---GDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQV 306

  Fly   334 LVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSG 398
            :.|||.. |||:    |..:.||                           ||.|
Mouse   307 MTEAFRN-LRKQ----RIEISRR---------------------------GNAG----------- 328

  Fly   399 GSGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT 461
                      ||  |.|.    .|..|.:|.|.|::|::|||:|:|||:.:|:|:|||::::|:.
Mouse   329 ----------DCLANPAV----PWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELK 379

  Fly   462 VNSAMVKVAEW----------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPY 510
            .|... |:..|                ||.:||:                 |:|.:|||:||.||
Mouse   380 TNGPR-KIGYWSEVDKMVVTLTELPSGNDTSGLE-----------------NKTVVVTTILESPY 426

  Fly   511 IMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGEL 575
            :|:|:  ..|.|.||.|:||||.|||..:||..|..|:|.:|.||.||:..:... .|:||||||
Mouse   427 VMMKK--NHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTK-IWNGMVGEL 488

  Fly   576 VRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640
            |..:||||||.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:
Mouse   489 VYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFA 553

  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPG 705
            |||||:|||.||||||:||                 |.|:..:                     |
Mouse   554 YIGVSVVLFLVSRFSPYEW-----------------HTEEFED---------------------G 580

  Fly   706 AQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAAS 770
            .:|                    .||...|||.::||.||||.||||||||:||||:||||....
Mouse   581 RET--------------------QSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 625

  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNK 835
            |:|||||:||||||||||||||||||:||.|.|||:.|||:.||||..|||.:|||||:|.:.:|
Mouse   626 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDK 690

  Fly   836 MWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGI 899
            ||.||.|.: .|||.|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:||
Mouse   691 MWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 755

  Fly   900 ATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYIL 963
            |||.||:|:.|:|||||.|.|.|.|.||:|||||:|.||.....| :...|.||||||||:||||
Mouse   756 ATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYIL 820

  Fly   964 IGGLLVSVFVAILEYCFRSRD-------SRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLG-- 1019
            :|||.:::.||::|:|::||.       :.||::.:...|.:       .||.|: ||.:|..
Mouse   821 VGGLGLAMLVALIEFCYKSRAEAKRMKMTLSAATRNKARLSI-------TGSTGE-NGRVMTPEF 877

  Fly  1020 PSS--AVPGGMPSSHQRSTLTD 1039
            |.:  |||...|......::||
Mouse   878 PKAVHAVPYVSPGMGMNVSVTD 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	131/458 (29%)
		ANF_receptor	55..461	CDD:279440	122/413 (30%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	245/441 (56%)
		Lig_chan	632..967	CDD:278489	181/336 (54%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	129/445 (29%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	245/441 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846191
Domainoid	1	1.000	347	1.000	Domainoid score	I1032
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm8866
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760