Protein Alignment GluRIB and Ir76b

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_061511889.1
• Gene: Ir76b / 1280702
• VectorBaseID: AGAMI1_009346
• Length: 658
• Species: Anopheles gambiae
• Alignment Length: 787
• Identity: 164/787 - (20%)
• Similarity: 271/787 - (34%)
• Gaps: 269/787 - (34%)

  Fly   413 AKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWN---D 474
            |:.|.:. :|||                     ...||...|..|........|:.||...   |
Mosquito    27 AERWPDK-DHGD---------------------PQRRRYGMTATVAVALAMMMMIVVATTQLGVD 69

  Fly   475 DAGLQPL------NAKYVRLRPHVEFE-KNR------------TYIVTTVLEEPYIMLKQVAFGE 520
            ..|:.|:      ..:|.:|......| |.|            |..|||:.:.|      :::..
Mosquito    70 AQGIAPVEWDGNETTEYYQLEMDASAEVKEREMQELRRRLTGTTLRVTTLQDWP------LSYTV 128

  Fly   521 KLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRK-EADIAI 584
            |::|.....|...:|.:.|.::....|||.:.:....||....|     |.|.:|:.. .||:|:
Mosquito   129 KINGTYIGAGVAFELLEFLMEKFNFTYELVMPEQNIVGSSNDMA-----GSVLQLLTNGTADMAV 188

  Fly   585 AAMTITAERERVIDFSKPFMSLGISIMIK-KPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVL 648
            :.:.|.|:..:.|.:|.. :..|..|||. :|::...| ...:.|.::::|:.::.|.:.|..::
Mosquito   189 SFLPILADARQHIRYSTG-LDEGEWIMIMVRPMESASG-SGLLAPFNRDVWILILVSLLAVGPII 251

  Fly   649 F--FVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAG 711
            :  .:.|.     ||.:.:.|                     ||
Mosquito   252 YGLLILRH-----RLTKDKEQ---------------------II--------------------- 269

  Fly   712 AAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTL 776
                                     :::.:..||...|.|:||..|||...|.||..|||:.|..
Mosquito   270 -------------------------YTLPHCVWFVYGALMKQGSTLSPTGDSTRILFASWWIFIT 309

  Fly   777 ILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGS--------------------- 820
            ||.|.|||||.||||:.:...|||:.||: .:.|.|:.|:..|:
Mosquito   310 ILTSFYTANLTAFLTLSKFTLPINNAEDV-RRKEKQFVTIRGGAIEYAIKNRDEALNALSVLVDK 373

  Fly   821 -TWDFFRRSQIGLHNKMWEYMNSRKHVFV---PTYDEGIKRVRNSKGKYA-LLVE---SPKNE-- 875
             ..||  .:.:...:.:.:.:..:.:|||   |..|..|         || .||.   :||||
Mosquito   374 RLVDF--TTNVNDSDTLADKVAKQNYVFVRDRPAIDHMI---------YADYLVRRKINPKNERV 427

  Fly   876 ---YVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAE 937
               |..|..|.    :.||   :.||.  |..:......:..:|.:.|.| ::|.:......|||
Mosquito   428 HCPYATATTPF----LKRN---RAFGY--PPNTEWNRIFDPELLKMVEGG-IVKYKLHDRLPKAE 482

  Fly   938 CSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGG 1002
            ......|.|.. :|...::...:::::.|.:.|:.|...|..||..:.|
Mosquito   483 ICPQNLGGTER-QLKNRDLVMTYFVMVTGFVTSIVVFASELGFRYLNQR---------------- 530

  Fly  1003 GMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCAS 1067
                    |.|..:             :..|:....|......||..:        |:.||   .
Mosquito   531 --------KLNEQL-------------AQQQQQQQQDQQPTSKKLATE--------RISYL---G 563

  Fly  1068 LQY----YPPAQLSATPPDAGDSLHMNAHGQVXHEHAQESRLXRTPCAPTIRRIMANSRQETEKM 1128
            .|:    .||      ||          :.:| ..|.|:.:|           ::.:| :.|.|:
Mosquito   564 KQFTTGDSPP------PP----------YAEVFSRHQQQQQLG----------VLGDS-ERTGKL 601

  Fly  1129 MGGGHGG 1135
            ...|.||
Mosquito   602 FDDGSGG 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	14/69 (20%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	110/490 (22%)
		Lig_chan	630..966	CDD:459656	80/371 (22%)
Ir76b	XP_061511889.1	None