DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and GRIN3A

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:NP_597702.2 Gene:GRIN3A / 116443 HGNCID:16767 Length:1115 Species:Homo sapiens


Alignment Length:613 Identity:134/613 - (21%)
Similarity:248/613 - (40%) Gaps:146/613 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   423 GDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMV--------------KVAEWN 473
            |..:||:|......||:|.|:....         .:..:.|:..:              ::..|.
Human   430 GQYLSRFLANTTFRGLSGSIRVKGS---------TIVSSENNFFIWNLQHDPMGKPMWTRLGSWQ 485

  Fly   474 D-----DAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQV----------------- 516
            .     |.|:.|..|:  |.:.|.:........|.|::|.|::..::|                 
Human   486 GGKIVMDYGIWP
EQAQ--RHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMT 548

  Fly   517 -------AFGEKLHGNN-----RFE----GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAH 565
                   :....||.:|     :|:    |||.||.:.:|:::..:::|.:|.||.||:.|   :
Human   549 NDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK---N 610

  Fly   566 GGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLS 630
            |.|.|:||:|:|..|.:|:.:.:|...|.:||||:.||.|..:.|:::......| :.:||.||.
Human   611 GHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLH 674

  Fly   631 QEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPL 695
            ..:|:.:   ::.:.|...|::.:   ||:                        .|.|:      
Human   675 WTMWLGI---FVALHITAVFLTLY---EWK------------------------SPFGL------ 703

  Fly   696 PAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPR 760
                   ||..:..:...:..:||:.......|.:.|:                       ..|:
Human   704 -------TPKGRNRSKVFSFSSALNICYALLFGRTVAI-----------------------KPPK 738

  Fly   761 SVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQ---YGTLLHGSTW 822
            ..:||.....|..|.:..:|:|||||||.:..|::...::...|..:....|   :||:...|..
Human   739 CWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAE 803

  Fly   823 DFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY-ALLVESPKNEY-VNAREPCDT 885
            |:.|:|...:|    |||   :...||...:|::.::|...|. |.:::....:| |:....|..
Human   804 DYVRQSFPEMH----EYM---RRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861

  Fly   886 MKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSE 950
            :.||:....:|:||..|..|.|...|:..:...|.:|.:..|.:| ||....|.......|...:
Human   862 LTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK-WYRVVPCGKRSFAVTETLQ 925

  Fly   951 LSLSNVAGIFYILIGGLLVSVFVAILEY 978
            :.:.:.:|:|.:|..|..:|:...|.|:
Human   926 MGIKHFSGLFVLLCIGFGLSILTTIGEH 953

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 11/73 (15%)
ANF_receptor 55..461 CDD:279440 8/37 (22%)
PBP2_iGluR_AMPA 497..938 CDD:270433 109/478 (23%)
Lig_chan 632..967 CDD:278489 68/339 (20%)
GRIN3ANP_597702.2 PBP1_iGluR_NMDA_NR3 30..497 CDD:107372 12/75 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..118
ANF_receptor 127..469 CDD:279440 9/47 (19%)
PBP2_iGluR_NMDA_Nr3 512..908 CDD:270438 107/473 (23%)
Lig_chan 676..942 CDD:278489 68/339 (20%)
PPP2CB binding site. /evidence=ECO:0000250 951..987 1/3 (33%)
GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7 1062..1095
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155734
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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