DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and Grik4

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	952	Identity:	304/952 - (31%)
Similarity:	468/952 - (49%)	Gaps:	216/952 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 QAYVDVINTADAFKLSR--------LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPF--V 131
            :|.|:|    |.|:|.|        .:|....:||.::|| :.||.|...:.:.....::|.  |
Mouse    61 KAKVEV----DIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121

  Fly   132 TPWFPEKVLTPSSGFLDF------ALSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQ 187
            .|          ..|:.|      .|::.|   |...|:...:.|:.......:....:.||.|:
Mouse   122 AP----------EEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLE 176

  Fly   188 QIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDL 252
            ::.:......::..|.::....:.:      ..|::|...:...|::.....|:..||:: ..:|
Mouse   177 KLLRQFLISKDTLSVRMLDDTRDPT------PLLKEIRDDKTATIIIHANASMSHTILLK-AAEL 234

  Fly   253 RLGRRTYHYLLSGL---------VMDDRWESEIIEFGAINITGFRIVDTNRRLVREF----YDSW 304
            .:....|.|:.:.|         ::|||          :||.||.|.:.:....:||    ..||
Mouse   235 GMVSAYYTYIFTNLEFSLQRMDSLVDDR----------VNILGFSIFNQSHAFFQEFSQSLNQSW 289

  Fly   305 KR-------LDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMV 362
            :.       ..|.:|           :||::|||:.:|.|..::             .|||.:.|
Mouse   290 QENCDHVPFTGPALS-----------SALLFDAVYAVVTAVQEL-------------NRSQEIGV 330

  Fly   363 AQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKIS 427
                                                       :.|.|.:|:    .|:||..:.
Mouse   331 -------------------------------------------KPLSCGSAQ----IWQHGTSLM 348

  Fly   428 RYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHV 492
            .|||.||:|||||.|:||..|:|.||.|.:::.|.| ...::.:|:...||...:..|.......
Mouse   349 NYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRN-GFQQIGQWHVAEGLSMDSRLYASNISDS 412

  Fly   493 EFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNY 557
            .|  |.|.:|||:||.||:|||  ...:::.||:|:||:|.|:...||:.|..||::|||.||.|
Mouse   413 LF--NTTLVVTTILENPYLMLK--GNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVY 473

  Fly   558 GSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGV 622
            |..:  |:|.|.||||||:.::||:|:|.:|||||||:|||||||||:|||||:.:..:.:.||.
Mouse   474 GVPE--ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGY 536

  Fly   623 FSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPP 687
            |||::|.|..:|:.::.:|:.||.|||.|:|.:|:||          .||.|.|.
Mouse   537 FSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEW----------YSPHPCAQ---------- 581

  Fly   688 GIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQ 752
                                                    |..:.:||::|:.||.||.:..|||
Mouse   582 ----------------------------------------GRCNLLVNQYSLGNSLWFPVGGFMQ 606

  Fly   753 QGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLL 817
            ||..::||::|.|..:..|:.||||:||||||||||||||:||..||.|.:|||.||.::|||:.
Mouse   607 QGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIH 671

  Fly   818 HGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNARE 881
            .||:..||:.|:...:.:||.||.|:: .|||.:.:|||.||.||  .||.|:||..|||...|.
Mouse   672 GGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRN 734

  Fly   882 PCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGET 946
             |:..::|..|||||:||..|:||..:|..:||:|.|:||..|..|:.||| |..:|...:|...
Mouse   735 -CNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWW-EGGKCPKEEDHRA 797

  Fly   947 SHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSA 988
              ..|.:.|:.|||.:||.||:|::|:|:||:.:..|.|.::
Mouse   798 --KGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEAS 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	91/439 (21%)
		ANF_receptor	55..461	CDD:279440	88/422 (21%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	191/441 (43%)
		Lig_chan	632..967	CDD:278489	128/335 (38%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	93/443 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	190/437 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750