Protein Alignment GluRIB and grin2ba

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001429729.1
• Gene: grin2ba / 110438919
• ZFINID: ZDB-GENE-090821-2
• Length: 1606
• Species: Danio rerio
• Alignment Length: 1240
• Identity: 258/1240 - (20%)
• Similarity: 459/1240 - (37%)
• Gaps: 362/1240 - (29%)

  Fly     6 KLSCLWPSFLLWLTWSSGGG----GGSGVGVSAQPS--------LTEKIPLGAIFEQGTDEVQSA 58
            :|.|:|  .||.|..:.|..    ||.||.....|:        |.:.:.:..:....:.||..|
Zfish    37 QLICVW--LLLLLLPAVGQSRRERGGGGVAQFLPPAAPYPPVSKLLQGLSIAVVLVGNSSEVVMA 99

  Fly    59 -------FKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSF 116
                   |..|.|...:.:.:           :|..|...:.:.||:..:.  :.:.|.|..|..
Zfish   100 GARDKEEFGQAALVPGVEMLT-----------MNETDPKSIIKSICDLMTE--HWLQGVVFGDDT 151

  Fly   117 D------TLHSYSNTFQMPFVTPWFPEKVL----TPSSGFLDFALSMRPDYHQA--IIDTIQFYG 169
            |      .|...|....:|.:.......::    ..:|.|..|..|:.   .||  :::.::.|.
Zfish   152 DQEAIAQILDFISAQTHIPILGVKGGSSMIMAAKDDNSMFFQFGPSIE---QQASVMLNIMEEYD 213

  Fly   170 WRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQI---------- 224
            |    |::          .|.....||.:.|..::...|.|..:..|    ||::
Zfish   214 W----YIF----------SIVTTYYPGYQDFVTKIRSTIENSFVGWE----LEEVLLLDMSVDDG 260

  Fly   225 -GRFEN------KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEF--G 280
             .:.:|      ..::|...|:....|:.|....:.|....|.:::..||..|. :....||  |
Zfish   261 DAKIQNLLKKLQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDA-DHIPAEFPTG 324

  Fly   281 AINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKK 345
            .|:::               ||.|         ..|.|      |.:.|.|.|:..|.:.::
Zfish   325 MISVS---------------YDEW---------DYGLE------ARVRDGVAVIATATSTMM--- 356

  Fly   346 PDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC 410
                   :.|...||:.::.                        .|.....|..:|
Zfish   357 -------MDRGPHTLLKSEC------------------------HGAPDKKSPMTG--------- 381

  Fly   411 NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDD 475
                       :.:::.|||..|..||  .::.|::||.:::..|.::.:.......:|.:|.:.
Zfish   382 -----------NNNEVLRYLMNVTFEG--RNLSFSEDGYQMHPKLVIILLDKERQWDRVGKWENG 433

  Fly   476 AGLQPLNAKYVRLRPHVEF-------EKNRTYIVTTVLEE-PYIMLKQVAFGEKLHGN------- 525
            :    |:.|| .:.|..|.       |.:...|||  ||| |:::::.|   :.|.|.
Zfish   434 S----LSMKY-HVWPRFELYSGPEAREDDHLSIVT--LEEAPFVIVEDV---DPLSGTCMRNTVP 488

  Fly   526 --------NRFE-----------GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGM 571
                    |:.:           |:|.|:...:||.:...|:|.||.:|.:|.:   .:|.|:||
Zfish   489 CRKQLKALNQTQDSAVYIKRCCKGFCIDILKKIAKNVKFTYDLYLVTNGKHGKK---INGTWNGM 550

  Fly   572 VGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVS 636
            |||:|.|.|.:|:.::||..||..|||||.||:..|||:|:.:. ..|....:|:.|.|.::|:.
Zfish   551 VGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVWIM 614

  Fly   637 VIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGP 701
            :....:.||.:..|:..:.                 .|..::..||:.:
Zfish   615 MFVMLLLVSAIAVFIFEYF-----------------SPVGYNRCLADGR---------------- 646

  Fly   702 PTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGR 765
                              .||.|           .|::..:.|............: :||..:.:
Zfish   647 ------------------EAGGP-----------SFTIGKAIWLLWGLVFNNSVPVQNPRGTTSK 682

  Fly   766 IAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQT------EVQYGTLLHGSTWDF 824
            |..:.|.||.:|.::|||||||||:..|..|..::...|...|.      ..::||:.:|||...
Zfish   683 IMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTERN 747

  Fly   825 FRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCD--TM 886
            .|.:...:|:.|.:: :.|..|      |.::.::..| ..|.:.::....|:..| |.|.  |:
Zfish   748 IRNNYRDMHSYMVKF-HQRNVV------EALESLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTI 804

  Fly   887 KVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSEL 951
            ..|:...:.|:|||....|..|..::||:|.|..:||:.:|...|.  ...|. |:..|...|:|
Zfish   805 GSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL--TGICH-HEKNEVMSSQL 866

  Fly   952 SLSNVAGIFYILIGGLLVSVFVAILE--------YCFRSRDSRSASSGSGMGLGMGLGGGMSGGS 1008
            .:.|:||:||:|...:.:|:...|.|        :||                 ||:..|..|.:
Zfish   867 DVDNMAGVFYMLGAAMALSLITFIAEHVFYWHMRFCF-----------------MGVCSGKPGFT 914

  Fly  1009 L-------GKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCA 1066
            .       ...:|..:...|||:  ..||:...:|     |:.....::.::          |.|
Zfish   915 FTISREIYSCIHGVEIEDKSSAL--NSPSATMNNT-----HSNILRLLRTAK----------NMA 962

  Fly  1067 SLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEHAQESRLXRTPC-APTI--RRIMANSRQETEKM 1128
            ||     :.::.:|..|.|.:...:......|| :.|....:.| ||.:  ..:.::...|.|:.
Zfish   963 SL-----SGVNGSPHSALDFIRRESSVYDISEH-RRSLAGHSDCKAPYLPDDNMFSDYISEVERT 1021

  Fly  1129 MGGGH 1133
            .|..|
Zfish  1022 FGNLH 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	77/474 (16%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	117/477 (25%)
		Lig_chan	630..966	CDD:459656	77/345 (22%)
grin2ba	NP_001429729.1	None