DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grin3b

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_017952374.2	Gene:	grin3b / 100497172	XenbaseID:	XB-GENE-990106	Length:	1005	Species:	Xenopus tropicalis

Alignment Length:	979	Identity:	182/979 - (18%)
Similarity:	352/979 - (35%)	Gaps:	300/979 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LSRLICNQF-SRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVL-------------T 141
            |:|.:|... ::|:.::|. ..:.:....|...|:..::||::....|:::             |
Frog    87 LTRWLCQVLVAQGIAAVLAFPQAQEELLQLEFLSSFLEIPFISILEQEQIVPLATKNPFHLQMDT 151

  Fly   142 PSS--GFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVEL 204
            .||  ..:|...|:..:.....:|.|..:.|       ||                  .|.|..|
Frog   152 QSSVENLMDIFFSVLQNSSWEEVDIITCHPW-------DS------------------ASIQRYL 191

  Fly   205 VKRISNVSMAIEFLHTLEQ--IGRFENKH-----------IVLDCPTEMAKQILIQHVRDLRLGR 256
            ....:.||..|..:|.:::  :..|..:|           ::..|....: .::.:..||..|..
Frog   192 TSNTTLVSRTILNIHPVDESALVPFLQQHFESMKNPQFPMLLYGCDARRS-SLVFRVARDCGLEA 255

  Fly   257 RTYHYLLSGLVMDDRWESE-----IIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAG 316
            ..:|:::...:..:...:|     ::.:|          :.:|..:.:|
Frog   256 HEFHWMIGHPLNGEEMTTEGMPPGLLAYG----------EVSRPTMEKF---------------- 294

  Fly   317 RESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGG 381
                      :.|||.::..|.:..:..:||            |.:.|:
Frog   295 ----------IRDAVGLVTRAISAAVHVRPD------------LALIQS---------------- 321

  Fly   382 GGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFND 446
                                     .::||..:...|. ..|..:||:|......|.||.|..::
Frog   322 -------------------------MVNCNDKQTKQNE-SSGSYLSRFLANTSFSGQTGQIYVSN 360

  Fly   447 DGRRVNYTLHVVEMTVNS----AMVKVAEWND-----DAGL--------QPLNAKYVRLRPHVEF 494
            :.....:...:..:..:|    ..|.|..|..     :.||        :|....:.|.:..
Frog   361 NLIHTEHHYRIWSLVRDSLGDPTWVTVGGWRQGKMEVEEGLWQSRIQQWEPAPGGFARTKLR--- 422

  Fly   495 EKNRTYIVTTVLEEPYIMLKQV-AFGEKLHG--------NNR------FE--------------- 529
                   |.|::|.|::..::| |.|....|        ||.      ||
Frog   423 -------VVTLVEHPFVFTREVDADGSCPAGQMCLDPRTNNSAVLDVLFEELNSPNGSVPLEYKT 480

  Fly   530 ---GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITA 591
               |||.||.:.|:::|..::||.:|.||.||:.|...   |.|:||:|:...|.:|:.:.:|.:
Frog   481 CCYGYCIDLLEKLSEDLRFDFELYIVGDGKYGARKGDR---WTGLVGDLLSGAAHMAVTSFSINS 542

  Fly   592 ERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSP 656
            .|..||||:.||.|..:.|:::.....:| :.:||.||...:||.:   ::.:.|...|::.:
Frog   543 ARSTVIDFTSPFYSTSLGILVRMRDTASP-IGAFMWPLHWSMWVGI---FVALHITALFLTFY-- 601

  Fly   657 HEWRLVQQQPQQSQSP---DPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAA 718
             ||:          ||   .||
Frog   602 -EWK----------SPFGMTPH------------------------------------------- 612

  Fly   719 LSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYT 783
                    |.:.:.:.:..|..|..:..|  |.:.....:|:..:||:....|..|.|:::||||
Frog   613 --------GRNRTKIFSYSSALNLCYAIL--FGRTVSSKTPKCCTGRVLMNLWAIFCLLVLSSYT 667

  Fly   784 ANLAAFLTVERMVTPINSPEDLAMQTEVQ---YGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKH 845
            |||||.:..::....::...|..:....|   :||:...|...:.::|...:||.|.::.
Frog   668 ANLAAVMVGDKTFEALSGIHDPKLHHPSQGFRFGTVWESSAEQYIKKSFPEMHNYMRKFS----- 727

  Fly   846 VFVPTYDEGIKRVRNSKGKY-ALLVESPKNEY-VNAREPCDTMKVGRNLDTKGFGIATPLGSALK 908
              ||...:|:..::...... |.:::....:| |:....|..:.:|:....:|:||..|..|.|.
Frog   728 --VPATSDGVHLLKTDPPTLNAFIMDKALLDYEVSIDSDCKLLTIGKPFAIEGYGIGLPQNSPLT 790

  Fly   909 DPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFV 973
            ..|:..:...|.:|.:..|.:| ||:...|.......|...::.:.:.:|:|.:|..|...|:..
Frog   791 SNISEFISRYKSSGFMDTLHDK-WYKMVPCGKRVYAVTETLQMGIYHFSGLFVLLCIGFCGSLLT 854

  Fly   974 AILE 977
            :::|
Frog   855 SLME 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	61/429 (14%)
		ANF_receptor	55..461	CDD:279440	57/403 (14%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	109/481 (23%)
		Lig_chan	632..967	CDD:278489	65/342 (19%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	62/430 (14%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	108/486 (22%)
		Lig_chan	582..848	CDD:395014	65/342 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910