Protein Alignment GluRIB and grin2b

DIOPT Version :9

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1028
• Identity: 227/1028 - (22%)
• Similarity: 387/1028 - (37%)
• Gaps: 319/1028 - (31%)

  Fly   131 VTPWFPEKVLTPSSGFLDFALSMRPDYHQAIIDTIQ--FYGW--RKIIYLYDSHDGLLRLQQIYQ 191
            ||.:||        |:.||...:|        .||:  |.||  .::|:|..|.|
 Frog   167 VTTYFP--------GYQDFENKVR--------STIENSFVGWELEEVIHLDMSLD---------- 205

  Fly   192 GLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQIL-IQHVRDLRLG 255
                .|:|       :|.|            |:.:.::..|:|.|..|.|..|. :.|  .:.|.
 Frog   206 ----DNDS-------KIQN------------QLKKLQSPVILLYCTKEEATYIFEVAH--SVGLT 245

  Fly   256 RRTYHYLLSGLVMDDRWESEIIEF--GAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRE 318
            ...|.:::..||..|. ::...||  |.|:::               ||.|.
 Frog   246 GYGYTWIVPSLVAGDT-DTVPAEFPTGLISVS---------------YDEWD------------- 281

  Fly   319 SISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGG 383
                     ||.               |.:.|:.:       .:...||||....:|
 Frog   282 ---------YDL---------------PARVRDGI-------AIITTAASTMLSEHN-------- 307

  Fly   384 GNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDG 448
                   ....|.|.......||..:.:..|             |||..|..||  .::.|::||
 Frog   308 -------SIPQSKSSCYNIQESRVYEAHMLK-------------RYLINVTFEG--RNLSFSEDG 350

  Fly   449 RRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKY-----VRLRPHVEFEKNRTYIVTTVLEE 508
            .:::..|.::.:.......:|.::.|    :.|..||     ..|.|:.|..|:....:.|:.|.
 Frog   351 YQMHPKLVIILLNQQRKWERVGKYKD----RSLKMKYYVWPVFELYPNSEEHKDEHLSIVTLEEA 411

  Fly   509 PYIMLKQVAFGEKLHG---------------NNRFE-----------GYCKDLADLLAKELGINY 547
            |:::::.|   :.|.|               .||.|           |:|.|:...:||.:...|
 Frog   412 PFVIVEDV---DPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTVKFTY 473

  Fly   548 ELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMI 612
            :|.||.:|.:|.:   .:|.|:||:||:|.|.|.:|:.::||..||..|:|||.||:..|||:|:
 Frog   474 DLYLVTNGKHGKK---INGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMV 535

  Fly   613 KKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAH 677
            .:. ..|....:|:.|.|.::||.:....:.||.|..||..:.                 .|..:
 Frog   536 SRS-NGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYF-----------------SPVGY 582

  Fly   678 HEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNS 742
            :..||:.:.||           ||                                  .|::..:
 Frog   583 NRCLADGREPG-----------GP----------------------------------SFTIGKA 602

  Fly   743 FWFSLAAFMQQGCDL-SPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLA 806
            .|............: :|:..:.:|..:.|.||.:|.::|||||||||:..|..|..::...|..
 Frog   603 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKK 667

  Fly   807 MQ------TEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY 865
            .|      ...::||:.:|||....|.:.:.:|:.|.:: |.|      :..:.:..::..| ..
 Frog   668 FQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKF-NQR------SVQDALLSLKTGK-LD 724

  Fly   866 ALLVESPKNEYVNAR-EPCD--TMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKL 927
            |.:.::....|:..| |.|.  |:..|:...|.|:|||....|..|..::||:|.|..:||:.:|
 Frog   725 AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEEL 789

  Fly   928 RNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILE--------YCFRSRD 984
            ...|.  ...|...|: |...|:|.:.|:||:||:|...:.:|:...|:|        :||
 Frog   790 EALWL--TGICHNEKN-EVMSSQLDIDNMAGVFYMLAAAMALSLITFIMEHLFFWQLRHCF---- 847

  Fly   985 SRSASSGSGMGLGMGLGG---GMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAK 1046
                     ||:..|..|   .:|.|.....:|..:....||:  ..||:...:|     |:...
 Frog   848 ---------MGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAM--NSPSATMNNT-----HSNIL 896

  Fly  1047 LTIQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEH 1099
            ..::.::          |.|:|     :.::.:|..|.|.:...:......||
 Frog   897 RLLRTAK----------NMANL-----SGVNGSPQSALDFIRRESSVYDISEH 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	67/353 (19%)
		ANF_receptor	55..461	CDD:279440	65/336 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	116/476 (24%)
		Lig_chan	632..967	CDD:278489	79/344 (23%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	68/360 (19%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	117/478 (24%)
		NMDAR2_C	837..1449	CDD:402274	23/133 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910