DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grid2

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	992	Identity:	233/992 - (23%)
Similarity:	432/992 - (43%)	Gaps:	222/992 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAY-VDVINTADAFKLSRLICNQFSRGVY 105
            |.:||||::...:....|:.|:.:.|||....:.|...: |..::..:.|:..:..|:..|:|:.
Frog    27 IHIGAIFDESAKKDDEVFRMAVADLNLNEDILQTEKITFSVTFVDGNNPFQAVQEACDLMSQGIL 91

  Fly   106 SMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEK--VLTP--------SSGFLDFALSMRPDYH-- 158
            :::.::...|..:|.|.::...:|.:   |.::  ..||        |||..|:.||:||..:
Frog    92 ALVSSIGCASAGSLQSLADAMHIPHL---FIQRSTARTPRSGCGLQRSSGIDDYTLSVRPPVYLN 153

  Fly   159 QAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHT--- 220
            ..|:..:..|.|:|.|..||::..:..:|:...  |...:...|.|.|..:|::..|..|..
Frog   154 DVILRVVTEYAWQKFIVFYDNNYDIRGIQEFLD--RVSQQGMDVALQKVENNINRMITGLFATMR 216

  Fly   221 LEQIGRFEN---KHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEII--EFG 280
            :|::.|:.:   :.|::..||  ..:..|..|.:..|.....|:::....::|....|::  ..|
Frog   217 IEELNRYRDTLRRAILVMSPT--TAKAFITEVVETNLVAFDCHWIIINEEINDLDVQELVRRSIG 279

  Fly   281 AINI----------TGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLV 335
            .:.|          :..|....|.|:      |....||:.......|..:   ..:||.|.:|.
Frog   280 RLTIIRQTFPVPHNSSQRCFRGNHRI------STSLCDPKDPFSQNMEITN---MYIYDTVLLLA 335

  Fly   336 EAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGS 400
            .||:|.|..:...
Frog   336 NAFHKKLEDRKWH---------------------------------------------------- 348

  Fly   401 GGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMT---- 461
             .|||  |.|.....  ..|:.|..:...::|..:.||||.:.|::||...|....::...
Frog   349 -SMAS--LTCIRKNS--KPWQGGRSMLETVKKGGVSGLTGALDFSEDGGNPNIYFEILGTNYGEE 408

  Fly   462 VNSAMVKVAEWNDDAGLQ--------PLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAF 518
            :...:.|:..||...||.        ..|.:.|.||            |.||||||::|:.:...
Frog   409 LGRGIRKLGFWNPVTGLNGSLTDRKLENNMRGVVLR------------VATVLEEPFVMVSENVL 461

  Fly   519 GEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIA 583
            |:.    .:::|:..|:.|.|:..||..||:.:..|..|||.:  |.|.|:|::|||:.|.||:.
Frog   462 GKP----KKYQGFSIDVLDALSSYLGFKYEIYVASDHKYGSPQ--ADGSWNGLIGELLLKRADMG 520

  Fly   584 IAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVL 648
            |:|:|||.:||.|:||:..:|...:.::::| .::|..:|:.:.|....:|..:..:.:.|.:::
Frog   521 ISALTITPDRENVVDFTTRYMDYSVGVLLRK-AEKTVDMFACLAPFDLSLWACIAGTVLLVGLLV 584

  Fly   649 FFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAA 713
            :.::..:|...::                                           |:.|:.
Frog   585 YLLNWLNPPRLQM-------------------------------------------GSMTST--- 603

  Fly   714 ALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLIL 778
                                    :::||.||...:|:|||.::...:::.|:...:|:.|.||:
Frog   604 ------------------------TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIV 644

  Fly   779 ISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQI------GLHNKMW 837
            |||||||||||||:.|:.:.|.|.:||:.||::.|||:...:.::..|...:      .::::||
Frog   645 ISSYTANLAAFLTISRIESSIQSLQDLSRQTDIPYGTVFDSAVYEHVRVKGMNPFERDSMYSQMW 709

  Fly   838 EYMN----SRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAR-EPCDTMKVGRNLDTKGF 897
            ..:|    |..:|....  |||::|::  |.||.:.::...||:... :.|....||..:..:|:
Frog   710 RMINRSNGSENNVQESL--EGIQKVKH--GNYAFVWDAAVLEYIAINDQDCSFYTVGNTIADRGY 770

  Fly   898 GIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSH--SELSLSNVAGIF 960
            |||...||..:|..:..:|.|::||::..|::|||....:|..|...:|..  |.|.:.:.:|:|
Frog   771 GIALQHGSPYRDIFSQRILELQQNGDMDILKHKWWPRNGQCELHSSMDTKQKGSSLDIKSFSGVF 835

  Fly   961 YILIGGLLVSVFVAILE 977
            .||..|:::|.|:|::|
Frog   836 CILAAGIVLSCFIAMVE 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	92/469 (20%)
		ANF_receptor	55..461	CDD:279440	85/436 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	120/451 (27%)
		Lig_chan	632..967	CDD:278489	83/347 (24%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	94/473 (20%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	122/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910