DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and LOC100334689

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	1143	Identity:	352/1143 - (30%)
Similarity:	536/1143 - (46%)	Gaps:	214/1143 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEV------QSAFKYAMLNHNLN---- 69
            |.|:..|.|              :...|.:|.||||....|      :.|||:|:.|.|.|
Zfish    18 LFWIQSSFG--------------MPHVIRIGGIFEQTDGPVALVSSEELAFKFAVNNINRNRTLL 68

  Fly    70 -VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-T 132
             .::..:::|.    ||..|:|:.||..|:|.|.||.::.|.....|.:.:.|..|..::|.: .
Zfish    69 PNTTLTYDIQR----INIYDSFEASRKACDQLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQV 129

  Fly   133 PWFPEKVLTPSSGFLDFALSMRPDYHQ---AIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLR 194
            .|...    |......|..::.|||..   ||:|.:||..|:....:||...||:|||::.  :.
Zfish   130 RWKHH----PMDNRDTFYANLYPDYSSLSYAILDLVQFLKWKTATVVYDDSTGLIRLQELI--MA 188

  Fly   195 PGNESFQVELVKRISNVSM-AIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT 258
            |...:.::    :|..:.| .::....|:::.|.....|:.||...||.|||.|   ...:|..|
Zfish   189 PSRYNIRL----KIRQLPMDTVDTRPLLKEMKRSREFRIIFDCSHTMAAQILKQ---AQMMGMMT 246

  Fly   259 --YHYLLSGL-VMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSW---KRLDPQMSVGAGR 317
              |||:.:.| :|....|.  ..|..:|:|||||::.:...|....:.|   :::.|:...|...
Zfish   247 EYYHYIFTTLDLMAINLEP--YRFCGVNMTGFRILNVDNPQVASIVEKWSLERQIPPKPDSGLLE 309

  Fly   318 ESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGG 382
            ..::..|||.||||.::                                    |..|.::..
Zfish   310 GIMTTDAALTYDAVHIV------------------------------------SVSYQHAPQ--- 335

  Fly   383 GGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-D 446
                                |...:|.|:..|    .|..|.:...::::...:||||.:.|| .
Zfish   336 --------------------MTVNSLQCHRHK----PWRFGGRFMSFIKESHWDGLTGRLCFNRT 376

  Fly   447 DGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYI 511
            .|.|.::.|.:|.:. ...:.||.:|:...||..............:...||:.::||:|||||:
Zfish   377 TGLRTDFDLDIVSLK-EDGLQKVGKWSASGGLNITEVPRQNGMNITDSLSNRSLVITTILEEPYV 440

  Fly   512 MLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
            |||:  ..:.|.||:||||:|.||...||..||.:||:.||.||.||.:...  |.|:||:.||:
Zfish   441 MLKK--SDKALVGNDRFEGFCIDLLKELASILGFSYEIHLVPDGKYGFQDDK--GQWNGMIRELM 501

  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSY 641
            ...||:|:|.:|||..||:.|||||||::.||||:.:||.....|.|||:||::.:|||.::.:|
Zfish   502 EHRADLAVAPLTITFMREKAIDFSKPFLNTGISILYRKPNSTNSGFFSFLNPMTPDIWVYILLAY 566

  Fly   642 IGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGA 706
            :|||.|||.::||||:||.            |.|                    |..||
Zfish   567 LGVSCVLFVIARFSPYEWY------------DAH--------------------PCNPG------ 593

  Fly   707 QTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASW 771
                                   |..|.|.|::.|||||.:.:.||||.:|.|:::|.||....|
Zfish   594 -----------------------SDVVENNFTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIW 635

  Fly   772 FFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKM 836
            :|||||:|||||||||||||||||.:|::|.:|||.||:::||.:..|:|..||::|::....||
Zfish   636 WFFTLIIISSYTANLAAFLTVERMDSPVDSADDLAKQTKIEYGVVKDGATMSFFKKSRVSTFEKM 700

  Fly   837 WEYMNSRKHV-FVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900
            |.:|:||:.. ||.:.::||:||  .|..||||:||...|||..|. |:..:||..:|:||:||.
Zfish   701 WAFMSSRQSTSFVKSIEDGIQRV--LKSDYALLMESTTIEYVTRRN-CNLTQVGGIIDSKGYGIG 762

  Fly   901 TPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIG 965
            ||.||..:|.|.:|:|.:.|:|.|..|:.||| ..:.|...:..||  ..:.:.|:.|||.:|..
Zfish   763 TPKGSPYRDKITIAILGILEDGRLHMLKEKWW-SGSSCLEDERYET--GPMGIQNLGGIFIVLAS 824

  Fly   966 GLLVSVFVAILEYCFRSRDSRSASSGSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPS 1030
            ||::||||||.|:.::.|.:.....   :.|..|.|...:...: :..|.....|::|
Zfish   825 GLVLSVFVAIGEFIYKLRKTAEREQ---VFLQCGDGRDQTVVHV-RETGEAQAPPAAA------- 878

  Fly  1031 SHQRSTLTDTMHAKAKLTIQASRDYDNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQV 1095
            ||.....:| .||..:....|.:...          .||:...|::|.|....|...|:......
Zfish   879 SHAEDGRSD-QHALLQRPSPARKGQH----------ELQHRDDARVSMTCLGDGHLRHVPGAVPE 932

  Fly  1096 XHEHAQESRLXRTPCAPTIRRIMANSRQETEKMMGGGH 1133
            ..::..|.....|.....||..||:....:....|..|
Zfish   933 SRDYGSEMITAFTINRRDIRHQMASQNGGSSSKPGSDH 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	110/457 (24%)
		ANF_receptor	55..461	CDD:279440	102/428 (24%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	190/441 (43%)
		Lig_chan	632..967	CDD:278489	130/335 (39%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590926
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650