DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIB and grin2cb

DIOPT Version :9

Sequence 1:NP_001261621.2 Gene:GluRIB / 44484 FlyBaseID:FBgn0264000 Length:1182 Species:Drosophila melanogaster
Sequence 2:XP_009305071.2 Gene:grin2cb / 100333648 ZFINID:ZDB-GENE-100308-2 Length:1328 Species:Danio rerio


Alignment Length:1225 Identity:250/1225 - (20%)
Similarity:430/1225 - (35%) Gaps:329/1225 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 GTDEVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTADAFKLSRLICNQFSRGVYS 106
            |...|..|..::...|:..:..|         ..|:.....::|..:...|...:|.  :....|
Zfish    35 GPPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPITVLVNDTNPRALLTRLCQ--TMAAES 97

  Fly   107 MLGAVSPDSFDT------LHSYSNTFQMPFVTPWFPEKVLTP----SSGFLDFALSMRPDYHQAI 161
            :.|.|..|..|:      |...|:...:|.|.......|:.|    .|.||....|:....: |:
Zfish    98 LHGVVFEDDVDSEAVAQILDFVSSQTSIPIVGISGGSAVVIPHKADGSTFLQMGASIDQQIN-AM 161

  Fly   162 IDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGR 226
            ...::.|.|...:              :...|.||.|:| |:.::..::.|.   ||..|:.:..
Zfish   162 FKVMEEYNWGNFV--------------VITSLYPGYETF-VDYIRSFTDTSY---FLWELQDVLS 208

  Fly   227 FENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVD 291
            ||......|..|....|.:...|..:........||.       |..|::...|...|       
Zfish   209 FEMSVGANDIRTRRLLQQVDSQVYLVYCSHEEAQYLF-------RMASDVGLLGPGYI------- 259

  Fly   292 TNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRNNVQRR 356
                        |  :.|.::|  |....:..|:.....:.::.:.:.|.||::           
Zfish   260 ------------W--IVPSLAV--GNPEAAPPASFPVGVISIITDRWRKTLRQR----------- 297

  Fly   357 SQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNT-AKGWVN-- 418
                 |.:..|......:::....|....|.:                    ||:: .|.:.|  
Zfish   298 -----VREGVAIIVKGVHSFHKHRGFIPEGHS--------------------DCSSPVKSYANNS 337

  Fly   419 --------AWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDD 475
                    :|||                 .|:.||.||...|.::.::.:...:...||..:  :
Zfish   338 LFRHMLNVSWEH-----------------KDLSFNSDGYLTNPSMVIIALDRENHWDKVGSY--E 383

  Fly   476 AGL----QPLNAKYVR-LRPHVEFEKNRTYIVTTVLEEPYIMLKQV--AFGEKLHG-------NN 526
            .|:    .|:..:|.. |.|   ...||...|.|:.|.|:::::.|  |.|..:..       :|
Zfish   384 GGILQMRYPVWPRYGSFLEP---VSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSN 445

  Fly   527 RFE---------------GYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
            |.|               |:|.|:...|::.:..:|:|.||.:|.:|   ....|.|:||:||:.
Zfish   446 RTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHG---KMVRGVWNGMIGEVF 507

  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSY 641
            .|.||:||.::||..||..::|||.||:..|||:|:.:. ..|....:|:.|.|..:||.:....
Zfish   508 YKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMC 571

  Fly   642 IGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGA 706
            :.|..|..||..:.                 .|..::..|.:.:.||           ||     
Zfish   572 LTVVAVTVFVFEYF-----------------SPVGYNRSLVSAKAPG-----------GP----- 603

  Fly   707 QTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDL-SPRSVSGRIAAAS 770
                                         .|::..|.|............: :|:..:.:|....
Zfish   604 -----------------------------TFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLV 639

  Fly   771 WFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQ------TEVQYGTLLHGSTWDFFRRSQ 829
            |.||.:|.::|||||||||:..|:.:..::...|...|      ...::||:.:|||....|.:.
Zfish   640 WAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFGTVPNGSTERNIRSNY 704

  Fly   830 IGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNS--KGKY-ALLVESPKNEYVNAR-EPCD--TMKV 888
            ..:|..|.:|           ..:|::...||  .||. |.:.::....|:..: |.|.  |:..
Zfish   705 PDMHTHMIKY-----------NQKGVEEALNSLKTGKLDAFIYDAAVLNYMAGKDEGCKLVTIGS 758

  Fly   889 GRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSL 953
            |:...|.|:|||....|..|.||:||:|....:|:..:|...|.  ...|...|: |...|:|.:
Zfish   759 GKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL--SGICQNEKN-EVMSSKLDI 820

  Fly   954 SNVAGIFYILIGGLLVSVFVAILEYCFR-------------------SRDSRSASSG-SGMGLGM 998
            .|:||:||:|:..:.:|:.|...|:...                   ||...|..:| ..:|...
Zfish   821 DNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSDRLDFLLAISRGIYSCFNGVEDIGRST 885

  Fly   999 GLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMH--------AKAKLTIQASRDY 1055
            |:.......:..:||...||..:..:.......:.....|.|:.        ..|::.:..:.:.
Zfish   886 GIQNPDITANYAQANMLKMLQTAKDIVSSAKVENSLDNATKTIENWSRRSGSLPARIPLVTTTEK 950

  Fly  1056 DNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMNAHGQVXHEHAQESRLXRTPCAPTIRRIMAN 1120
            ..|...|:...:..:.|..|.|.|||                 ..|.:.....|       :|.|
Zfish   951 VPGHFSYIANVAENHIPHMQRSITPP-----------------FTQHTTTTSPP-------LMVN 991

  Fly  1121 SRQETEKMMGGGHGGTVTVSVPA--TCSSSMNGSHEGSLALSPSSGSATLMRHSP 1173
            .|             .:|...|.  |..:...|.::|.|.:| |..:..|..|.|
Zfish   992 HR-------------VLTRPTPLRYTLPARTRGLYDGMLPVS-SLSTPHLAMHDP 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIBNP_001261621.2 PBP1_iGluR_AMPA 43..478 CDD:107375 76/456 (17%)
ANF_receptor 55..461 CDD:279440 73/435 (17%)
PBP2_iGluR_AMPA 497..938 CDD:270433 118/477 (25%)
Lig_chan 632..967 CDD:278489 79/347 (23%)
grin2cbXP_009305071.2 PBP1_iGluR_NMDA_NR2 37..396 CDD:107373 77/464 (17%)
PBP2_iGluR_NMDA_Nr2 407..808 CDD:270436 119/479 (25%)
NMDAR2_C 845..>932 CDD:313729 12/86 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170590934
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.740

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