Protein Alignment GluRIB and grin3bb

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1027
• Identity: 205/1027 - (19%)
• Similarity: 368/1027 - (35%)
• Gaps: 286/1027 - (27%)

  Fly    44 LGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF-SRGVYSM 107
            |..:.|.|.:         .|.:||::.....|.|       :.|...|.|.:|... .:||.::
Zfish    69 LSGLAESGNN---------FLPYNLSLDVVAREAQ-------SGDPESLFRCVCQDIVVQGVSAV 117

  Fly   108 LG-AVSPDSFDTLHSYSNTFQMPFVT------PW-----FPEKVLT--PSSGFLDFALSM--RPD 156
            |. ..:.:....:...|:..::||::      |.     |..::.|  |.||.::..|::  |..
Zfish   118 LAFPQTQEEIVQMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSG 182

  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221
            :.:::  .:..:||.....|     .||:||..: |..|.....:..|....|...||
Zfish   183 WEESM--AVLCHGWEDAGLL-----DLLKLQGRF-GWGPSQWHLRAALNLSHSTARMA------- 232

  Fly   222 EQIGRFENKHIVLD-----------CPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESE 275
             .|..|.::|..||           ...|.|..:| :...||.|...|.|:::...:..|...|.
Zfish   233 -NISDFLSEHFNLDHSPPASVLLFGADPECASSVL-RSAHDLGLTLPTVHWIMGHPLSPDALHSI 295

  Fly   276 IIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNK 340
            .:..|   :..:..|| ::.|  :||.|                         ||:.::..|...
Zfish   296 GLPLG---LLAYGEVD-HKPL--DFYIS-------------------------DALQLINRAVTA 329

  Fly   341 ILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMAS 405
            ....:||.                                                     .:..
Zfish   330 ATVVRPDL-----------------------------------------------------ALIQ 341

  Fly   406 RALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVV-------EMTVN 463
            ..::|............|..|:|:|......||||.:....:..|| :|.|.|       :....
Zfish   342 NMVNCFDKPNKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRV-HTSHKVHIWSLRRDAVGQ 405

  Fly   464 SAMVKVAEWN------DDAGLQPLNAKYVRLRPHVEFEKNR----------TYIVTTVLEEPYIM 512
            ...|.|..|.      ::.||...::...|....:..|..|          ...|.|::|.|::.
Zfish   406 PTWVTVGSWEGGRLNVEEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVF 470

  Fly   513 LKQV-------------------------AFGEKLHGNNRF---------EGYCKDLADLLAKEL 543
            .::|                         .:.|:..||..|         .|||.||.:.|::::
Zfish   471 TREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDM 535

  Fly   544 GINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGI 608
            ...::|.:|.||.||:.|.   |.|.|:||:|:...||:|:.:.:|.:.|.:||||:.||.|..:
Zfish   536 NFEFDLYIVGDGKYGAVKG---GQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSL 597

  Fly   609 SIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPD 673
            .|:::......| :.:||.||...:|:.:   ::.:.|...|::.:   ||:
Zfish   598 GILVRSKDTAAP-IGAFMWPLHWSMWMGI---FVALHITALFLTLY---EWK------------- 642

  Fly   674 PHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFS 738
                       .|.|:             ||..:......:..:||:.        ..|::
Zfish   643 -----------SPFGM-------------TPHGRNRVKVFSYSSALNL--------CYAIL---- 671

  Fly   739 VWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPE 803
                       |.:.....:|:..:||.....|..|.|:::|||||||||.:..|:....::...
Zfish   672 -----------FGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIH 725

  Fly   804 DLAMQTEVQ---YGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY 865
            |..:....|   :||:...|..|:.::|...:|    |||.....   ||..:|:..::....:.
Zfish   726 DAKLHHPSQGFRFGTVRESSAEDYMKKSFPEMH----EYMRKFNE---PTTPDGVATLKTDPPQL 783

  Fly   866 -ALLVESPKNEY-VNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLR 928
             |.:::....:| |:....|..:.||:....:|:||..|..|.|...|:..|...|.:|.:..|.
Zfish   784 DAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLH 848

  Fly   929 NKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980
            :| ||:...|.......|...::.:.:.:|:|.:|..|:..::.....|:.|
Zfish   849 DK-WYKVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAF 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	85/476 (18%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	110/489 (22%)
		Lig_chan	630..966	CDD:459656	68/340 (20%)
grin3bb	XP_017213803.2	Periplasmic_Binding_Protein_type1	39..427	CDD:471960	84/475 (18%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	107/472 (23%)
		Lig_chan	618..885	CDD:459656	68/340 (20%)