DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and grin3bb

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_017213803.2	Gene:	grin3bb / 100333101	ZFINID:	ZDB-GENE-131122-77	Length:	1114	Species:	Danio rerio

Alignment Length:	1027	Identity:	205/1027 - (19%)
Similarity:	368/1027 - (35%)	Gaps:	286/1027 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQF-SRGVYSM 107
            |..:.|.|.:         .|.:||::.....|.|       :.|...|.|.:|... .:||.::
Zfish    69 LSGLAESGNN---------FLPYNLSLDVVAREAQ-------SGDPESLFRCVCQDIVVQGVSAV 117

  Fly   108 LG-AVSPDSFDTLHSYSNTFQMPFVT------PW-----FPEKVLT--PSSGFLDFALSM--RPD 156
            |. ..:.:....:...|:..::||::      |.     |..::.|  |.||.::..|::  |..
Zfish   118 LAFPQTQEEIVQMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSGLVELLLAVLQRSG 182

  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221
            :.:::  .:..:||.....|     .||:||..: |..|.....:..|....|...||
Zfish   183 WEESM--AVLCHGWEDAGLL-----DLLKLQGRF-GWGPSQWHLRAALNLSHSTARMA------- 232

  Fly   222 EQIGRFENKHIVLD-----------CPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESE 275
             .|..|.::|..||           ...|.|..:| :...||.|...|.|:::...:..|...|.
Zfish   233 -NISDFLSEHFNLDHSPPASVLLFGADPECASSVL-RSAHDLGLTLPTVHWIMGHPLSPDALHSI 295

  Fly   276 IIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNK 340
            .:..|   :..:..|| ::.|  :||.|                         ||:.::..|...
Zfish   296 GLPLG---LLAYGEVD-HKPL--DFYIS-------------------------DALQLINRAVTA 329

  Fly   341 ILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMAS 405
            ....:||.                                                     .:..
Zfish   330 ATVVRPDL-----------------------------------------------------ALIQ 341

  Fly   406 RALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVV-------EMTVN 463
            ..::|............|..|:|:|......||||.:....:..|| :|.|.|       :....
Zfish   342 NMVNCFDKPNKHELPSSGQYIARFLSNTSFVGLTGPVIVQRNLSRV-HTSHKVHIWSLRRDAVGQ 405

  Fly   464 SAMVKVAEWN------DDAGLQPLNAKYVRLRPHVEFEKNR----------TYIVTTVLEEPYIM 512
            ...|.|..|.      ::.||...::...|....:..|..|          ...|.|::|.|::.
Zfish   406 PTWVTVGSWEGGRLNVEEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVF 470

  Fly   513 LKQV-------------------------AFGEKLHGNNRF---------EGYCKDLADLLAKEL 543
            .::|                         .:.|:..||..|         .|||.||.:.|::::
Zfish   471 TREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDM 535

  Fly   544 GINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGI 608
            ...::|.:|.||.||:.|.   |.|.|:||:|:...||:|:.:.:|.:.|.:||||:.||.|..:
Zfish   536 NFEFDLYIVGDGKYGAVKG---GQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSL 597

  Fly   609 SIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPD 673
            .|:::......| :.:||.||...:|:.:   ::.:.|...|::.:   ||:
Zfish   598 GILVRSKDTAAP-IGAFMWPLHWSMWMGI---FVALHITALFLTLY---EWK------------- 642

  Fly   674 PHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFS 738
                       .|.|:             ||..:......:..:||:.        ..|::
Zfish   643 -----------SPFGM-------------TPHGRNRVKVFSYSSALNL--------CYAIL---- 671

  Fly   739 VWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPE 803
                       |.:.....:|:..:||.....|..|.|:::|||||||||.:..|:....::...
Zfish   672 -----------FGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIH 725

  Fly   804 DLAMQTEVQ---YGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKY 865
            |..:....|   :||:...|..|:.::|...:|    |||.....   ||..:|:..::....:.
Zfish   726 DAKLHHPSQGFRFGTVRESSAEDYMKKSFPEMH----EYMRKFNE---PTTPDGVATLKTDPPQL 783

  Fly   866 -ALLVESPKNEY-VNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLR 928
             |.:::....:| |:....|..:.||:....:|:||..|..|.|...|:..|...|.:|.:..|.
Zfish   784 DAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLH 848

  Fly   929 NKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980
            :| ||:...|.......|...::.:.:.:|:|.:|..|:..::.....|:.|
Zfish   849 DK-WYKVVPCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	83/474 (18%)
		ANF_receptor	55..461	CDD:279440	77/440 (18%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	110/489 (22%)
		Lig_chan	632..967	CDD:278489	68/339 (20%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	85/476 (18%)
grin3bb	XP_017213803.2	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	107/472 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590930
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840