Protein Alignment GluRIB and gria2

DIOPT Version :10

• Sequence 1: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: XP_031752085.1
• Gene: gria2 / 100216082
• XenbaseID: XB-GENE-966066
• Length: 937
• Species: Xenopus tropicalis
• Alignment Length: 1140
• Identity: 425/1140 - (37%)
• Similarity: 589/1140 - (51%)
• Gaps: 282/1140 - (24%)

  Fly    14 FLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQ 78
            ||:.:.|      |...||     .:..|.:|.:|.:|.|:..|||:..||.:    |:..|.|.
 Frog    10 FLVAVLW------GLITGV-----YSNSIQIGGLFPRGADQEYSAFRVGMLLY----STSEFRLT 59

  Fly    79 AYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPS 143
            .::|.:..|::|.::...|:||||||:::.|.....|.:|:.|:..|..:.|:||.|      |:
 Frog    60 PHIDNLEVANSFAVTNAFCSQFSRGVFAIFGFYDKKSVNTITSFCGTLHVSFITPSF------PT 118

  Fly   144 SGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK-- 206
            .|...|.:.||||...|::..|::|.|.|..|||||..||..||.:...  ...:.:||..:.
 Frog   119 DGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDA--AAEKKWQVTAINVG 181

  Fly   207 RISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGR--RTYHYLLSGLVMD 269
            .|:|......:....:.:...:.:.::|||..:....|:.|.:   .:|:  :.|||:::.|...
 Frog   182 NINNDRKDETYRSLFQDLEIKKERRVILDCERDKVNDIVDQVI---TIGKHVKGYHYIIANLGFT 243

  Fly   270 DRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVL 334
            |...|: |:||..|::||:|||.:..||.:|...|..|:.:...||...:|...:||.:|||.|:
 Frog   244 DGDLSK-IQFGGANVSGFQIVDYDDPLVAKFIQRWSTLEEKEYPGAHTTTIKYTSALTFDAVQVM 307

  Fly   335 VEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGG 399
            .|||.. |||:    |..:.||                           ||.|
 Frog   308 TEAFRN-LRKQ----RIEISRR---------------------------GNAG------------ 328

  Fly   400 SGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTV 462
                     ||  |.|.    .|.||.:|.|.|::|::|||:|:|||:.:|:|||||::::|:..
 Frog   329 ---------DCLANPAV----PWGHGVEIERALKQVQVEGLSGNIKFDQNGKRVNYTINIMELKS 380

  Fly   463 NSAMVKVAEW----------------NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYI 511
            |... |:..|                ||..||:                 |:|.||||:||.||:
 Frog   381 NGPR-KIGYWSEVDKMVVTVTDVLSANDSMGLE-----------------NKTVIVTTILEAPYV 427

  Fly   512 MLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELV 576
            |.|:.|  ::..||:|:||||.|||..:|:..|..|:|.:|.||.||:..:... .|:|||||||
 Frog   428 MFKKNA--DQFEGNDRYEGYCVDLAAEIARHCGFKYKLTIVADGKYGARDAETK-IWNGMVGELV 489

  Fly   577 RKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSY 641
            ..:||||||.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|
 Frog   490 YGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAY 554

  Fly   642 IGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGA 706
            ||||:|||.||||||:||                 |.|:..:                     |.
 Frog   555 IGVSVVLFLVSRFSPYEW-----------------HTEEFED---------------------GR 581

  Fly   707 QTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASW 771
            :|.:..::                    |||.::||.||||.||||||||:||||:||||....|
 Frog   582 ETQSNESS--------------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 626

  Fly   772 FFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKM 836
            :|||||:||||||||||||||||||:||.|.|||:.|||:.||||..|||.:|||||:|.:.:||
 Frog   627 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKM 691

  Fly   837 WEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIA 900
            |.||.|.: .|||.|..||:.|||.||||||.|:||..|||:..|:||||||||.|||:||:|||
 Frog   692 WTYMKSAEPSVFVKTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIA 756

  Fly   901 TPLGSALKD---------------------------------------PINLAVLTLKENGELIK 926
            ||..|.|::                                       |||||||.|.|.|.|.|
 Frog   757 TPKQSPLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKVSPINLAVLKLSEQGVLDK 821

  Fly   927 LRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASS 990
            |:|||||:|.||.....| :...|.||||||||:||||:|||.:::.||::|:|::||
 Frog   822 LKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR------- 879

  Fly   991 GSGMGLGMGLGGGMSGGSLGKANGSMMLGPSSAVPGGMPSSHQRSTLTDTMHAKAKLTIQASRDY 1055
                                                 ..:...:..|:|.|..||:|:|..|..
 Frog   880 -------------------------------------AEAKRMKIYLSDVMRNKARLSITGSTG- 906

  Fly  1056 DNGRVGYLNCASLQYYPPAQLSATPPDAGDSLHMN 1090
            :|||:      :...:|.|..:.:|     .:.||
 Frog   907 ENGRI------TTPEFPKAVHAVSP-----GMRMN 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	135/458 (29%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	242/480 (50%)
		Lig_chan	630..966	CDD:459656	178/376 (47%)
gria2	XP_031752085.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	131/443 (30%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	223/441 (51%)