DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria3

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	986	Identity:	417/986 - (42%)
Similarity:	555/986 - (56%)	Gaps:	167/986 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSS--RRFE 76
            |||.|:......||          ....|.:|.:|.:.|.:..|||.:|:..||.|.::  |.|:
Frog    10 FLLLLSLVGESCGG----------FPNTINIGGLFMRNTIQEHSAFLFAVQLHNTNQNNTERPFQ 64

  Fly    77 LQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLT 141
            |..:||.::::::|.::...|:|||||||::.|.....|.:||.|:.......|:||.|
Frog    65 LFHHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFITPSF------ 123

  Fly   142 PSSGFLDFALSMRPDYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVK 206
            |:...:.|.:.|||....||:..:..|.|:|.:||||:..|...||.|.:.....|  :|| ..:
Frog   124 PTDADVQFVIQMRPPLKGAILTLLNEYDWQKFVYLYDTERGFSILQAIMEAAVQNN--WQV-TAR 185

  Fly   207 RISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLSGLVMD 269
            .:.|:....||...:|::.|.:.|..|:||..|....||.|.|   .||:.|  |||:|:.|...
Frog   186 SVGNIKDVQEFKRIIEEMDRRQEKRFVIDCEVERINTILEQVV---ILGKHTRGYHYMLANLGFT 247

  Fly   270 DRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVL 334
            . :..|.:..|..|:|||:||:....:|::|...|.|||.:....|....:...:||.:|||.|:
Frog   248 G-FTLERVMHGGANVTGFQIVNNENPIVQQFLQRWVRLDEREFPEARNTPLKYTSALTHDAVLVI 311

  Fly   335 VEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGG 399
            .|||..:.|::.|     |.||                                          |
Frog   312 AEAFRYLRRQRVD-----VSRR------------------------------------------G 329

  Fly   400 SGGMASRALDC--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTV 462
            |.|      ||  |.|.    .|..|..|.|.|:.|:::|:||:|:|:..|||.|||:.|.|||.
Frog   330 SAG------DCLANPAV----PWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMTA 384

  Fly   463 NSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFE--------KNRTYIVTTVLEEPYIMLKQVAFG 519
            .... ||..||:          |.|..|..:.:        :|:|.||||:||.||:|.|:  ..
Frog   385 TKPR-KVGHWNE----------YERFVPAPDQQPTNESSSVENKTIIVTTILENPYVMKKK--NH 436

  Fly   520 EKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAI 584
            |.|.||:::||||.|||..:||.:||.|:|.:|:||.||:...... .|:|||||||...||||:
Frog   437 ELLDGNDKYEGYCVDLASEIAKHVGIKYKLSIVEDGKYGARDPETK-IWNGMVGELVYGRADIAV 500

  Fly   585 AAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLF 649
            |.:|||..||.||||||||||||||||||||.|..||||||::||:.|||:.::|:|||||:|||
Frog   501 APLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLF 565

  Fly   650 FVSRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAA 714
            .||||||:||.|    ....::.||.                     .||.||
Frog   566 LVSRFSPYEWHL----EDTDEARDPQ---------------------NPPDPP------------ 593

  Fly   715 LQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILI 779
                                |||.::||.||||.||||||||:||||:||||....|:|||||:|
Frog   594 --------------------NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIII 638

  Fly   780 SSYTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK 844
            |||||||||||||||||:||.|.||||.|||:.||||..|||.:|||||:|.::.|||.||.|.:
Frog   639 SSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAE 703

  Fly   845 -HVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALK 908
             .||..|.|:|:.|||.||||:|.|:||..|||:..|:||||||||.|||:||:|:|||.||||.
Frog   704 PSVFTKTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALG 768

  Fly   909 DPINLAVLTLKENGELIKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYILIGGLLVSVF 972
            .|:|||||.|.|.|.|.||:|||||:|.||.....| :...|.||||||||:||||:|||.:::.
Frog   769 TPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMM 833

  Fly   973 VAILEYCFRSR 983
            ||::|:|::||
Frog   834 VALIEFCYKSR 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	137/440 (31%)
		ANF_receptor	55..461	CDD:279440	128/411 (31%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	245/441 (56%)
		Lig_chan	632..967	CDD:278489	181/336 (54%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	139/451 (31%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	245/441 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37353
Inparanoid	1	1.050	715	1.000	Inparanoid score	I630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9529
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160