DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIB and gria1

DIOPT Version :9

Sequence 1:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster
Sequence 2:	XP_004912781.1	Gene:	gria1 / 100127569	XenbaseID:	XB-GENE-995621	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	408/978 - (41%)
Similarity:	557/978 - (56%)	Gaps:	162/978 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91
            |:.:||    :....|.:|.:|.....:..:||::|     |:..|...:|...:|::|.:|:|:
Frog    14 GAVLGV----NFPNHIQIGGLFPNQQSQEHAAFRFA-----LSQLSEPPKLLPQIDIVNISDSFE 69

  Fly    92 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPD 156
            ::...|:|||:|||::.|.....:.:.|.|:.....:.|:||.||  |.|.:    .|.|.:||:
Frog    70 MTYTFCSQFSKGVYAIFGFYDRKTVNMLTSFCGALHVCFITPSFP--VATSN----QFVLQLRPE 128

  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221
            ...|:|..|::|.|:|.:|:||:..||..||::..  ....:::||..|..::........|  .
Frog   129 LQDALISVIEYYKWKKFVYIYDADRGLSVLQKVLD--TAAEKNWQVTAVNILTTTEEGYRLL--F 189

  Fly   222 EQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITG 286
            :.:.:.:::.||:||.:|....||.|.|..|......|||:|:.|...|....:..|.|| |:||
Frog   190 QDLDKSKDRQIVIDCESERLNAILTQVVVKLEKNIIGYHYILANLGFMDIDMQKFKEAGA-NVTG 253

  Fly   287 FRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQ-------AALMYDAVFVLVEAFNKILRK 344
            |::|:....:|......||..|       |||.....       :||.||.|.|:.|||.. |||
Frog   254 FQLVNYTDTMVSRIMQQWKNYD-------GREQPRVDWKKPKYTSALTYDGVRVMAEAFQS-LRK 310

  Fly   345 KPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALD 409
            :    |.::.||                           ||.|                     |
Frog   311 Q----RIDISRR---------------------------GNAG---------------------D 323

  Fly   410 C--NTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEW 472
            |  |.|.    .|..|..|.|.|::|.:|||:|:::||:.|||.||||||:|:. :..:..:|.|
Frog   324 CLANPAV----PWGQGIDIQRALQQVRLEGLSGNVQFNEKGRRTNYTLHVLELK-HEGIRHIAHW 383

  Fly   473 NDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLAD 537
            |:|..|.|| |...:........:||||||||:||.||:|||:.|  ::|.||:||||||.:||.
Frog   384 NEDDKLIPL-ATDAQAGNDTIGVQNRTYIVTTILEAPYVMLKKNA--DQLEGNDRFEGYCVELAA 445

  Fly   538 LLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKP 602
            .:||.:|..|:|.:||||.||:..|... .|:|||||||...||:|:|.:|||..||.|||||||
Frog   446 EIAKHVGFKYKLEIVKDGKYGARDSDMK-AWNGMVGELVYGRADLAVAPLTITLVREEVIDFSKP 509

  Fly   603 FMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQ 667
            |||||||||||||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||
Frog   510 FMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-------- 566

  Fly   668 QSQSPDPHAHHEQL--ANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSS 730
                     |:|:.  ..:||                                           :
Frog   567 ---------HNEEFEEGKEQP-------------------------------------------T 579

  Fly   731 SAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERM 795
            :...|||.::||.||||.||||||||:||||:||||....|:|||||:|||||||||||||||||
Frog   580 TDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 644

  Fly   796 VTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVR 859
            |:||.|.:|||.|||:.||||..|||.:||:||:|.:..|||.||.|.: .|||.|.:||:.|||
Frog   645 VSPIESADDLAKQTEIAYGTLDSGSTKEFFKRSKIAVFEKMWTYMRSAEPSVFVKTTEEGMNRVR 709

  Fly   860 NSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGEL 924
            .||||||.|:||..|||:..|:||||||||.|||:||:|||||.||.|:..:|||||.|.|.|.|
Frog   710 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVL 774

  Fly   925 IKLRNKWWYEKAECSTHKDG-ETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSA 988
            .||::||||:|.||.:...| :...|.||||||||:||||||||.:::.||::|:|::||.....
Frog   775 DKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKK 839

  Fly   989 SSG 991
            ..|
Frog   840 MKG 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	129/443 (29%)
		ANF_receptor	55..461	CDD:279440	123/414 (30%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	244/443 (55%)
		Lig_chan	632..967	CDD:278489	177/338 (52%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	132/448 (29%)
gria1	XP_004912781.1	PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	244/443 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I895
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	715	1.000	Inparanoid score	I630
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D89427at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm9529
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060