DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR3.3

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001322169.1	Gene:	GLR3.3 / 840859	AraportID:	AT1G42540	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	970	Identity:	205/970 - (21%)
Similarity:	371/970 - (38%)	Gaps:	209/970 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLI--TDDATDRIRQ-TFEHAISVVNNELGVPLVGETEQVAYGNS----VQAFAQLCRLMQS 91
            :::|.|  .|....::.: ..:.|:..||:...: |.|....|:..||    .....:..|.|:.
plant    29 VKIGSIFSFDSVIGKVAKIAIDEAVKDVNSNPDI-LSGTKFSVSMQNSNCSGFMGMVEALRFMEK 92

  Fly    92 GVGAVFGP---AARHTASHLLN----------ACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIA 143
            .:..:.||   ...|..||:.|          ..|....|..:|:....:..|.:.:
plant    93 DIVGIIGPQCSVVAHMISHMANELRVPLLSFAVTDPVMSPLQFPYFIRTTQSDLYQM-------- 149

  Fly   144 NALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLR---RI 205
            :|:..||:.:.|...|..:        :|....|.|:.....|:....|.:  .||:.|.   .:
plant   150 DAIASIVDFYGWKEVIAVF--------VDDDFGRNGVAALNDKLASRRLRI--TYKAGLHPDTAV 204

  Fly   206 RKSE-----------DSRIVV--VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYK 257
            .|:|           ..||||  |.|..|.| :.::|:.:|:|...|.:|..:......|.....
plant   205 NKNEIMNMLIKIMLLQPRIVVIHVYSELGFA-VFKEAKYLGMMGNGYVWIATDWLSTNLDSSSPL 268

  Fly   258 YSE--ANITGI---RMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIA-- 315
            .:|  ..|.|:   |..:||.:..|:..::..:..|.|..:|:...:       .||:|.::|
plant   269 PAERLETIQGVLVLRPHTPDSDFKREFFKRWRKMSGASLALNTYGLY-------AYDSVMLLARG 326

  Fly   316 -----------ETTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKE------KTITGRIY 363
                       ..:.|     .|||...:..|:..:..|..:...:| :|:      ..:||::.
plant   327 LDKFFKDGGNISFSNH-----SMLNTLGKSGNLNLEAMTVFDGGEAL-LKDILGTRMVGLTGQLQ 385

  Fly   364 F-EGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFE------------------------------ 397
            | ....|....:|:|.:..:|:.::|.|.......
plant   386 FTPDRSRTRPAYDIINVAGTGVRQIGYWSNHSGLSTVLPELLYTKEKPNMSTSPKLKHVIWPGET 450

  Fly   398 FQRPPQAV---NFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELA 459
            |.:|...|   |..::..|        |.:.|:.|.:.|.:...:     |.|:|:.:|:.....
plant   451 FTKPRGWVFSNNGKELKIG--------VPLRVSYKEFVSQIRGTE-----NMFKGFCIDVFTAAV 502

  Fly   460 DKLGF--NFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMN 522
            :.|.:  ...|...||     .|...|.:.|::.|..|..|..:.|:.|.:.|.:::||:.|:..
plant   503 NLLPYAVPVKFIPYGN-----GKENPSYTHMVEMITTGNFDGVVGDVAIVTNRTKIVDFTQPYAA 562

  Fly   523 LGIAILYVKP-QKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNP--YPCIE 584
            .|:.:  |.| :|.....::|:.||:..:|...|..:|.|.:..:|:...:..|:..|  ..|:
plant   563 SGLVV--VAPFKKLNSGAWAFLRPFNRLMWAVTGCCFLFVGIVVWILEHRTNDEFRGPPKRQCV- 624

  Fly   585 EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIE 649
                     ||   |||:...:.....|.....|. |.:..||.|..||:.|||||:|.:.||::
plant   625 ---------TI---LWFSFSTMFFAHRENTVSTLG-RLVLIIWLFVVLIINSSYTASLTSILTVQ 676

  Fly   650 NPTSPINSVKDLADNKDDVQY--GAKRTGSTRNFFSTSEE---PIYIKMNEYLNAHPEMLMENNQ 709
            ..:|||..::.|.:..|.:.|  |:......||..:.||.   |:         ..||...:..:
plant   677 QLSSPIKGIESLRERDDPIGYQVGSFAESYLRNELNISESRLVPL---------GTPEAYAKALK 732

  Fly   710 QGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQ 774
            .|..|   |...|.:.|...:|......|....||....:.|:|.|..::.|.....:.|:|||.
plant   733 DGPSK---GGVAAIVDERPYVELFLSSNCAYRIVGQEFTKSGWGFAFPRDSPLAIDLSTAILELA 794

  Fly   775 EQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVY 839
            |.|.|.|:.:||   :....|:.::.:.....|.:.:..|::::..:..::::.:      |||.
plant   795 ENGDLQRIHDKW---LMKNACTLENAELESDRLHLKSFWGLFLICGVACLLALFL------YFVQ 850

  Fly   840 KKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIYSRSRNSS--QSIESLKTDSEEN 897
            ...:.|:.|..||:|.:               ..|:..|.|..|:  |...||..:.||:
plant   851 IIRQLYKKPTDDAIARD---------------QQQNHDSSSMRSTRLQRFLSLMDEKEES 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	83/422 (20%)
		ANF_receptor	46..380	CDD:279440	77/392 (20%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	97/380 (26%)
		Lig_chan	549..819	CDD:278489	69/276 (25%)
GLR3.3	NP_001322169.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780