DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	987	Identity:	187/987 - (18%)
Similarity:	365/987 - (36%)	Gaps:	245/987 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFCWISLIILSLSRVQAQFYGGNAYEASSGQS------IRLGLITDDATDR---IRQTFEHAIS 56
            :..|..:.|:||...| ..|:..|.:.:|....      :|:||:.|..:..   :|.:...|:|
plant     2 VRICIQTPILLSFLLV-LLFFISNCFASSQNNDDDKRIRVRVGLVLDLGSVEGKIVRSSVSMALS 65

  Fly    57 ---------------VVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQS-GVGAVFGPAARHTA 105
                           :|.:..|.||:             |...:..|:|: ||.|:.|..:...|
plant    66 DFYDNHNDYKTRLSLLVRDSHGEPLL-------------ALDSVVDLLQTEGVQAIIGGNSLLEA 117

  Fly   106 SHLLNACDSKDIPFI------------YPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRF 158
            ..|....:...:|.|            |.||...:       |.|..:: ..:...::.|:|:..
plant   118 KLLAELGEKARVPVISLNSPMSLSLSKYTHLIQAT-------HNSASEV-KGITAFLHGFDWNSV 174

  Fly   159 IFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSED--SRIVVVGSTTG 221
            ....|..:..:...|.|..:..:..|....:...::..:..|::.|:|:.:|  :.:.||..:..
plant   175 ALVLEDHDDWRESMHFMVDHFHENNVHVQSKVAFSVTSSEDSLMDRLRELKDLGTTVFVVHLSEV 239

  Fly   222 VA-ELLRQAQQVGIMNEDYTYIIGNLNLHTF------DLEEYKYSEANITGIRMFSPDQEEVRDL 279
            :| .|...|:::|:|.|.:.:|:.:.::.:|      ||.  |.:...:.|.:.:.|..:|:.:.
plant   240 IATRLFPCAEKLGMMGEGFAWILTSRSMSSFHDQFIDDLT--KEAMEGVVGFKSYIPMSKELHNF 302

  Fly   280 MEKLHQELGESEPVNSGSTFITMEMALTYD---AVRVIAETTKHLPYQPQMLNCSERHDNVQPDG 341
            ..:..:.|...|...|..|.:::.....:|   ::...||.|:.......:|..
plant   303 TLRWRKTLPVEEVTGSEITRLSISGVWAHDVAWSLASAAEVTRMPTVTSTLLEA----------- 356

  Fly   342 STFRNYMRSLEIKE---KTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQ 403
                       |||   |.::|....:........|:::.:..||..:||.|.....|..:|...
plant   357 -----------IKESRFKGLSGNFQLDDMKLLSDKFEIVNMIGSGERRVGFWNSNGSFSNRRQLS 410

  Fly   404 AV--NFNDI--DDGS-------------------LVNKT--FIVLISVATKPYASLVESIDTLIG 443
            :.  |...|  ..||                   ||..:  |..|:.|.|.|....:    |::
plant   411 STHDNLETIIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNRFPRLMKVETDPITHEI----TIV- 470

  Fly   444 NNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTS-GMLKEIVEGRADLAITDLTIT 507
                :|:.:::.:  |....||:..     :|..:...||.|. .......:.:.|.|:.|:|||
plant   471 ----EGFCIEVFQ--ASIAPFNYEV-----EYIRWLNGTNYTKLAYALHSQKDKYDAAVGDITIT 524

  Fly   508 SEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLS 572
            |:|...:||::|:..:|:.|:..|.:    :::.|..|.:..:|:        .|..||::..:
plant   525 SDRSMYVDFTLPYTEMGLGIVAAKER----SMWVFFQPLTPNLWI--------TSAAFFVLTGI- 576

  Fly   573 PIEWDNPYPCIEEPEELENQFT----INNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLI 633
             |.|     .||..|..|.|.:    |...:||....|:....|.....|| |.:..:|.|..||
plant   577 -IVW-----LIERAENKEFQGSWPQQIGVVIWFGFSTLVYAHREKLQHNLS-RFVVTVWVFAVLI 634

  Fly   634 MVSSYTANLAAFLTIENPTSPINSVKDLADNKDD--VQYGAKRTGSTRNF----FSTSEEPIYIK 692
            :|:||||.|.:.:|::.  ...|:.:|...:...  :...|....|.|..    .:|||:.....
plant   635 LVTSYTATLTSMMTVQQ--IRFNANEDYVGHLSGSLIANAALTNSSLRAMRLLGLNTSEDYAQAL 697

  Fly   693 MNE----------YLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPL 747
            ||:          ||..   :|.||...            |||..|....|
plant   698 MNKSVSYIVSELPYLKI---LLGENPGH------------FLMVKTQSTTN-------------- 733

  Fly   748 DEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNL 812
               |:|....|........::.:.:|:....|..::.:|:::.     ...:.||..:.:.:...
plant   734 ---GFGFMFQKGSELAPNVSREIAKLRTSERLNEMERRWFDKQ-----LPYTTDDTSNPITLYRF 790

  Fly   813 SGIYVVLVIGSIISIIISILCWCYFVYKKAKNYEVPFCDALAEEFRIVIR-----FSENERPLKS 872
            .|::::..:....::.:.::.|                  |.|.:.|::.     ||:.   |:.
plant   791 RGLFMITGVSFAFALAVLLILW------------------LRERWEILVNSVNIYFSQR---LRH 834

  Fly   873 AQSIYSRSRNSS 884
            .:.:::|:.:.|
plant   835 FRILFTRTIHPS 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	73/407 (18%)
		ANF_receptor	46..380	CDD:279440	64/379 (17%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	86/393 (22%)
		Lig_chan	549..819	CDD:278489	59/289 (20%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	74/410 (18%)
		ANF_receptor	55..387	CDD:279440	64/376 (17%)
		GluR_Plant	440..770	CDD:270404	87/399 (22%)
		Lig_chan	563..801	CDD:278489	59/292 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930