DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR1.4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	897	Identity:	175/897 - (19%)
Similarity:	335/897 - (37%)	Gaps:	213/897 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QSIRLGLITDDAT---DRIRQTFEHAIS---VVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQ 90
            :.:|:||:.|..:   ..:..:...|:|   .|||.... .|....:.::|:.:||.|....|:|
plant    44 EDVRIGLVVDMGSMEGKLVTTSISMALSDFYHVNNGYRT-RVSVLSRDSHGDPLQALAAAMDLLQ 107

  Fly    91 S-GVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNL----------HPSPEDIAN 144
            : .|.|:.|..:...|.:|....:...:|.|    |....|...:|          |.:..: |.
plant   108 TEQVEALVGGQSLLEAKNLAELGEKTKVPVI----SSFQVPSSLSLAKYNYFIQATHDTSSE-AK 167

  Fly   145 ALYDIVNQFEWSRFIFCYE-SAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKS 208
            .:..:.:.|:|...:..|| ..::.:.:..|:..:......|: .:.:.:::.|.:.:::::||.
plant   168 GIAALFSNFDWRTAVLIYEDDDDWRESIQPLVGHFQQNAIHIE-YKAEFSVSSNEECIMKQLRKF 231

  Fly   209 EDS--RIVVVGSTTGVA-ELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEY--KYSEANITGIRM 268
            :.|  ||.|...:..:| .|...|:::|:|.|.|.:|:...:::.|....|  |.....:.|.:.
plant   232 KASGIRIFVAHISERIANRLFPCARRLGMMEEGYAWILTARSMNNFQDTNYLAKEEMEGVIGFKS 296

  Fly   269 FSPDQEEVRDLMEKLHQELGESEPVNSGSTF------ITMEMA-----------LTYDAVRVIAE 316
            :.|..||:.:...:..:.|...|.|...|..      |...:|           ..||.:..|.|
plant   297 YIPLTEELHNFTLRWKRSLRLEEVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPE 361

  Fly   317 TTKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEGNVRKGF---TFDVIE 378
            :.||                                   |.::|.|.|   :.|.|   .|:::.
plant   362 SAKH-----------------------------------KGLSGDIKF---IDKKFISDKFEIVN 388

  Fly   379 LQTSGLVKVGTWEEGKDFEFQRP--------------------PQAVNFNDIDDGSLVNKTFIVL 423
            :...|...||.|..|.....:|.                    |:..:..:...|.  .|...||
plant   389 MIGRGERSVGLWNSGSFISNRRRRLSSTKALETIIWPGGSTRIPKIRSLKEKRHGK--KKKLRVL 451

  Fly   424 ISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFR----DGGNDYGSFNKTTNS 484
            :.........|....|...|.....||.:|:.:  ...|.||:...    .|..:|.::|....:
plant   452 VPAGNITPQILEVKTDFKTGVTAATGYCIDVFE--TSILPFNYEVEYIPWPGAINYKNYNDLVYT 514

  Fly   485 TSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSE 549
            ....     :.:.|.|:.|:|||..|...:||::||.::|:|::..|.:    :::....|.:..
plant   515 LYSQ-----KDKYDAAVGDITITDNRSLYVDFTLPFTDMGLAVVTAKDK----SMWIIFKPLTLS 570

  Fly   550 VWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIA 614
            :||.:.        .|||:  ...|.|     .||..:..:.|           |:..||...:.
plant   571 LWLTIA--------SFFIL--TGAIVW-----LIERHDNADFQ-----------GSCFQQIGTLL 609

  Fly   615 PKALST--------------RTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK 665
            ....||              |.:..:|.|..||:.|:|||.|.:.:|::       .::.|..|:
plant   610 CFGFSTLVFAHRERLQHNMSRFVVIVWIFAVLILTSNYTATLTSVMTVQ-------QIRGLKSNE 667

  Fly   666 DDVQYGAKRTGSTRNFFSTSEEPIYIKM---NEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMES 727
            :...:.|....:..|...|.:.|.|..:   :::.||               :::|| .:|:::.
plant   668 NIGFFSASIAANVVNDNPTFQGPRYKGLKTADDFTNA---------------LRNGT-ISFIVDE 716

  Fly   728 TSI----------EFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARL 782
            ...          ||..|...::|        .|:|.|..|..|...|.::.:.:|:....|..:
plant   717 VPYVKLFVAKHPSEFVIVETESVT--------NGFGFAFQKGSPLVQKVSREIEKLRRTEKLKAI 773

  Fly   783 KNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCW 834
            :| ||.:  ....||.|:|.. ..|.|....|::::..:....::|:.::.|
plant   774 EN-WWFQ--RQTTSATSEDTF-HPLTVYTFRGLFMITGVSFAFALIVYLIPW 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	80/404 (20%)
		ANF_receptor	46..380	CDD:279440	71/373 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	82/401 (20%)
		Lig_chan	549..819	CDD:278489	60/296 (20%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	80/407 (20%)
		ANF_receptor	64..390	CDD:279440	71/370 (19%)
		GluR_Plant	448..778	CDD:270404	81/398 (20%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	49/217 (23%)
		Lig_chan	570..810	CDD:278489	60/300 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.920