DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and GLR3.5

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001324013.1	Gene:	GLR3.5 / 817800	AraportID:	AT2G32390	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	1038	Identity:	222/1038 - (21%)
Similarity:	399/1038 - (38%)	Gaps:	258/1038 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFCWISLIILSLSRVQAQFYGGNAYEASSGQSIRLG-LITDDA--TDRIRQTFEHAISVVNNEL 62
            |..|..:|.:|.:.....:.:..|:..:|...|:.:| |.|.|:  ....:..|..||..:|.:.
plant    15 MLLCISALWVLPIQGAGRESFSRNSSSSSLPSSVNVGALFTYDSFIGRAAKLAFVAAIEDINADQ 79

  Fly    63 GVPLVGETEQVAYGNS-----VQAFAQLCRLMQSGVGAVFGPAAR---HTASHLLNACDSKDIPF 119
            .: |.|....:.:.::     |.....| :||::.|.|..||.:.   |..||:.|   ...:||
plant    80 SI-LRGTKLNIVFQDTNCSGFVGTMGAL-QLMENKVVAAIGPQSSGIGHIISHVAN---ELHVPF 139

  Fly   120 I-------------YPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKIL 171
            :             ||:....:..|.|.:        ||:.|.|:.|.|...:..:...||
plant   140 LSFAATDPTLSSLQYPYFLRTTQNDYFQM--------NAITDFVSYFRWREVVAIFVDDEY---- 192

  Fly   172 DHLMTRYGIK--GPVIKVMRYDLNL---------NGNYKSVLRRIRKSEDSRIVV--VGSTTGVA 223
                .|.||.  |..:...|..::.         |.:...:|..:...| |||.|  |...:|:
plant   193 ----GRNGISVLGDALAKKRAKISYKAAFPPGADNSSISDLLASVNLME-SRIFVVHVNPDSGL- 251

  Fly   224 ELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEA-----NITGIRMFSPDQEEVRDLMEKL 283
            .:...|:.:|:|...|.:|..:..|...|..|.....|     .:...|.::|:.:..|....:
plant   252 NIFSVAKSLGMMGSGYVWITTDWLLTALDSMEPLDPRALDLLQGVVAFRHYTPESDNKRQFKGR- 315

  Fly   284 HQELGESEPVNSGSTFITMEMALTYDAVRVIAE---------TTKHLPYQPQMLN-------CSE 332
            .:.|...|.:.|...|.:..: ..||:|.::|.         .|......|.:.|       .|:
plant   316 WKNLRFKESLKSDDGFNSYAL-YAYDSVWLVARALDVFFSQGNTVTFSNDPSLRNTNDSGIKLSK 379

  Fly   333 RHDNVQPDGSTFRNYMRSLEIKEKTITGRIYF--EGNVRKGFTFDVIELQTSGLVKVGTWEEGKD 395
            .|  :..:|..|...:  ||:....:||:|.|  |.| |....:|::.::::|.::||.|.....
plant   380 LH--IFNEGERFLQVI--LEMNYTGLTGQIEFNSEKN-RINPAYDILNIKSTGPLRVGYWSNHTG 439

  Fly   396 FEFQRPPQAV------------NFNDI----------------DDG-----SLVNKTFIVLISVA 427
            |.. .||:.:            ..|:|                ::|     .:.|:       |:
plant   440 FSV-APPETLYSKPSNTSAKDQRLNEIIWPGEVIKPPRGWVFPENGKPLKIGVPNR-------VS 496

  Fly   428 TKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGF-----NFTFRDGGNDYGSFNKTTNSTSG 487
            .|.|||..::   .:|   .:|:.:|:.:.....|.:     ...:.||        |...|...
plant   497 YKNYASKDKN---PLG---VKGFCIDIFEAAIQLLPYPVPRTYILYGDG--------KKNPSYDN 547

  Fly   488 MLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILY-VKPQKAPPALFSFMDPFSSEVW 551
            ::.|:.....|:|:.|:||.:.|.:.:||:.||:..|:.::. ||..|:.|  :||:.||:.|:|
plant   548 LISEVAANIFDVAVGDVTIITNRTKFVDFTQPFIESGLVVVAPVKGAKSSP--WSFLKPFTIEMW 610

  Fly   552 LYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPK 616
            ...|..:|.|....:|:......|:..|      |..     .|....||:...:.....|....
plant   611 AVTGALFLFVGAVIWILEHRFNEEFRGP------PRR-----QIITVFWFSFSTMFFSHRENTVS 664

  Fly   617 ALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNF 681
            .|. |.:..:|.|..||:.|||||:|.:.||::..||.|..:..|.
plant   665 TLG-RFVLLVWLFVVLIINSSYTASLTSILTVQQLTSRIEGMDTLI------------------- 709

  Fly   682 FSTSEEPIYIK---------MNEYLNAHPEML--MENNQQGVDKVKSGTK------------YAF 723
              .|.|||.::         :|| ||..|..:  :::.::.:..::.|.:            |..
plant   710 --ASNEPIGVQDGTFAWKFLVNE-LNIAPSRIIPLKDEEEYLSALQRGPRGGGVAAIVDELPYIK 771

  Fly   724 LMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWW- 787
            .:.|.|       .|....||......|:|.|..::.|.....:.|:|:|.|:|.|.:::.||.
plant   772 ALLSNS-------NCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAILQLAEEGKLEKIRKKWLT 829

  Fly   788 --NEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCW-CYFVYKKAKNYEVPF 849
              :|     |:.:..|....::.|.:..|::  |:.|.:..|.:::.|| .::.|::.:..|...
plant   830 YDHE-----CTMQISDTENYQISVQSFWGLF--LICGVVWFIALTLFCWKVFWQYQRLRPEESDE 887

  Fly   850 CDALAEE-------------FRIVIRF-------------SENERPLKSAQSIYSRSRNSSQS 886
            ..|.:||             |:.:|:.             .::.:.||..||    |..:|||
plant   888 VQARSEEAGSSRGKSLRAVSFKDLIKVVDKREAEIKEMLKEKSSKKLKDGQS----SAENSQS 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	91/421 (22%)
		ANF_receptor	46..380	CDD:279440	83/390 (21%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	93/402 (23%)
		Lig_chan	549..819	CDD:278489	64/295 (22%)
GLR3.5	NP_001324013.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780